Drug scores

Drugs fNeg fPos sum genes GOs Ensembl
Dinaciclib 34 356 3.9696E0 CDK1, CDK2, CDK5, CDK9 DNA replication, G1/S transition of mitotic cell cycle, MAPK cascade, apoptotic process, calcium ion-dependent exocytosis, cardiac muscle cell proliferation, cell cycle arrest, cell proliferation, gene expression, innate immune response, mitotic cell cycle, mitotic cell cycle phase transition, protein import into nucleus, translocation, protein phosphorylation, protein targeting to membrane, protein ubiquitination, transcription from RNA polymerase II promoter, transcription, DNA-dependent, viral transcription ENSG00000123374, ENSG00000136807, ENSG00000164885, ENSG00000170312
Alsterpaullone 82 308 2.4685E0 CDK1 DNA replication, MAPK cascade, apoptotic process, cardiac muscle cell proliferation, gene expression, innate immune response, mitotic cell cycle, mitotic cell cycle phase transition, protein import into nucleus, translocation, protein phosphorylation, protein ubiquitination ENSG00000170312
Bosutinib 49 341 1.7474E0 ABL1, BCR, CDK2, MAP2K1, MAP3K2, SRC G1/S transition of mitotic cell cycle, MAPK cascade, Ras protein signal transduction, apoptotic process, cell cycle, cell cycle arrest, cell differentiation, cell migration, cell proliferation, cellular component organization, immune response, inflammatory response, innate immune response, integrin activation, muscle cell differentiation, neutrophil degranulation, peptidyl-tyrosine phosphorylation, phagocytosis, protein phosphorylation, response to external stimulus, transcription elongation from RNA polymerase II promoter, transcription, DNA-dependent ENSG00000097007, ENSG00000123374, ENSG00000169032, ENSG00000169967, ENSG00000186716, ENSG00000197122
Ibalizumab 295 95 1.5449E0 CD4 T cell activation, calcium-mediated signaling, cellular biosynthetic process, immune response, interleukin-2 biosynthetic process, macromolecule biosynthetic process, peptidyl-tyrosine phosphorylation ENSG00000010610
Hymenialdisine, Indirubin-3'-Monoxime, Olomoucine, SU9516 45 345 1.5011E0 CDK2, CDK5 G1/S transition of mitotic cell cycle, calcium ion-dependent exocytosis, cell cycle arrest, cell proliferation, protein targeting to membrane, transcription, DNA-dependent ENSG00000123374, ENSG00000164885
Flavopiridol 55 335 1.1495E0 CDK2 G1/S transition of mitotic cell cycle, cell cycle arrest, cell proliferation, transcription, DNA-dependent ENSG00000123374
Pazopanib hydrochloride 293 97 0.6895E0 FGF1, FGFR3, FLT1, ITK, KDR, KIT, PDGFRA, PDGFRB ERK1 and ERK2 cascade, MAPK cascade, angiogenesis, apoptotic process, astrocyte differentiation, behavior, calcium ion import, canonical Wnt receptor signaling pathway, cell development, cell differentiation, cell migration, cell proliferation, chemotaxis, developmental growth, endothelial cell migration, endothelial cell proliferation, epithelial cell proliferation, focal adhesion assembly, gene expression, immune response, intracellular protein kinase cascade, lipid metabolic process, mesenchymal cell proliferation, mitosis, phosphatidylinositol 3-kinase cascade, platelet activation, positive chemotaxis, programmed cell death, protein phosphorylation, protein ubiquitination, smoothened signaling pathway, transcription from RNA polymerase II promoter, tyrosine phosphorylation of Stat1 protein, tyrosine phosphorylation of Stat3 protein, tyrosine phosphorylation of Stat5 protein, vascular endothelial growth factor receptor signaling pathway ENSG00000068078, ENSG00000102755, ENSG00000113263, ENSG00000113578, ENSG00000113721, ENSG00000128052, ENSG00000134853, ENSG00000157404
Anakinra 329 61 0.5472E0 IL1RN MAPK cascade, amine transport, apoptotic process, heterotypic cell-cell adhesion, protein phosphorylation ENSG00000136689
Pimasertib, Selumetinib, Trametinib 359 31 0.4955E0 MAP2K1 MAPK cascade, Ras protein signal transduction, cell cycle, cell differentiation, cell migration, cell proliferation, innate immune response, protein phosphorylation, transcription elongation from RNA polymerase II promoter ENSG00000169032
Procaine 305 85 0.4716E0 RYR2, SCN5A cardiac muscle contraction, cellular process, epithelial cell proliferation, sodium ion transport, transport ENSG00000183873, ENSG00000198626
Dantrolene sodium hydrate 305 85 0.4716E0 RYR2 cardiac muscle contraction, transport ENSG00000198626
Adenosine triphosphate 325 65 0.3867E0 ABL1, ABL2 apoptotic process, immune response, muscle cell differentiation, neuron projection development, peptidyl-tyrosine phosphorylation, protein phosphorylation ENSG00000097007, ENSG00000143322
Amiloride 284 106 0.3867E0 ASIC2, PLAU, SLC9A1 blood coagulation, intracellular protein kinase cascade, synapse assembly ENSG00000090020, ENSG00000108684, ENSG00000122861
Ketoconazole 310 80 0.3838E0 CYP17A1, CYP26A1 cellular biosynthetic process, hormone biosynthetic process, retinoic acid receptor signaling pathway ENSG00000095596, ENSG00000148795
Regorafenib 349 41 0.3638E0 ABL1, DDR2, EPHA2, FGFR1, FLT1, FRK, KDR, KIT, NTRK1, PDGFRA, PDGFRB, RET ERK1 and ERK2 cascade, MAPK cascade, Ras protein signal transduction, angiogenesis, apoptotic process, behavior, cAMP biosynthetic process, calcium ion import, cardiac muscle cell proliferation, cell cycle, cell differentiation, cell migration, cell proliferation, cellular process, chemotaxis, endothelial cell migration, endothelial cell proliferation, establishment of protein localization to plasma membrane, fibroblast migration, fibroblast proliferation, focal adhesion assembly, gene expression, immune response, lipid metabolic process, mesenchymal cell proliferation, metanephric glomerulus development, muscle cell differentiation, neuron apoptotic process, neuron projection development, osteoblast differentiation, peptidyl-tyrosine phosphorylation, phosphatidylinositol 3-kinase cascade, platelet activation, positive chemotaxis, programmed cell death, protein kinase B signaling cascade, protein phosphorylation, specification of organ identity, synaptic transmission, glutamatergic, transcription from RNA polymerase II promoter, tyrosine phosphorylation of Stat1 protein, tyrosine phosphorylation of Stat3 protein, tyrosine phosphorylation of Stat5 protein, vascular endothelial growth factor receptor signaling pathway ENSG00000077782, ENSG00000097007, ENSG00000102755, ENSG00000111816, ENSG00000113721, ENSG00000128052, ENSG00000134853, ENSG00000142627, ENSG00000157404, ENSG00000162733, ENSG00000165731, ENSG00000198400
Ellagic Acid 313 77 0.3511E0 CA2, CSNK2A1, PRKACA, PRKCB, SYK B cell differentiation, B cell receptor signaling pathway, I-kappaB kinase/NF-kappaB cascade, MAPK cascade, Wnt receptor signaling pathway, angiogenesis, bone resorption, calcium-mediated signaling, cell adhesion mediated by integrin, cell cycle arrest, cell growth, cell proliferation, cellular biosynthetic process, cytokine secretion, immune response, insulin receptor signaling pathway, intracellular pH reduction, macromolecule biosynthetic process, mast cell degranulation, mitotic cell cycle phase transition, peptidyl-tyrosine phosphorylation, protein catabolic process, protein export from nucleus, protein phosphorylation, vascular endothelial growth factor receptor signaling pathway ENSG00000072062, ENSG00000101266, ENSG00000104267, ENSG00000165025, ENSG00000166501
Fostamatinib, Fostamatinib disodium 340 50 0.3398E0 SYK B cell differentiation, MAPK cascade, bone resorption, calcium-mediated signaling, cell adhesion mediated by integrin, cellular biosynthetic process, cytokine secretion, macromolecule biosynthetic process, mast cell degranulation, peptidyl-tyrosine phosphorylation ENSG00000165025
Cabozantinib 359 31 0.3196E0 FLT1, KDR, KIT, MET, PDGFRA, PDGFRB, RET ERK1 and ERK2 cascade, MAPK cascade, angiogenesis, behavior, calcium ion import, cell differentiation, cell migration, cell proliferation, chemotaxis, endothelial cell migration, endothelial cell proliferation, focal adhesion assembly, gene expression, lipid metabolic process, mesenchymal cell proliferation, metanephric glomerulus development, phosphatidylinositol 3-kinase cascade, platelet activation, positive chemotaxis, programmed cell death, protein phosphorylation, transcription from RNA polymerase II promoter, tyrosine phosphorylation of Stat1 protein, tyrosine phosphorylation of Stat3 protein, tyrosine phosphorylation of Stat5 protein, vascular endothelial growth factor receptor signaling pathway ENSG00000102755, ENSG00000105976, ENSG00000113721, ENSG00000128052, ENSG00000134853, ENSG00000157404, ENSG00000165731
Dovitinib lactate 361 29 0.315E0 FGFR1, FGFR3, FLT1, KDR, PDGFRB ERK1 and ERK2 cascade, MAPK cascade, angiogenesis, apoptotic process, astrocyte differentiation, behavior, calcium ion import, canonical Wnt receptor signaling pathway, cardiac muscle cell proliferation, cell cycle, cell development, cell differentiation, cell migration, cell proliferation, chemotaxis, developmental growth, endothelial cell migration, endothelial cell proliferation, epithelial cell proliferation, focal adhesion assembly, lipid metabolic process, mesenchymal cell proliferation, mitosis, neuron projection development, phosphatidylinositol 3-kinase cascade, positive chemotaxis, protein phosphorylation, protein ubiquitination, smoothened signaling pathway, specification of organ identity, transcription from RNA polymerase II promoter, tyrosine phosphorylation of Stat1 protein, tyrosine phosphorylation of Stat3 protein, vascular endothelial growth factor receptor signaling pathway ENSG00000068078, ENSG00000077782, ENSG00000102755, ENSG00000113721, ENSG00000128052
Lenvatinib 362 28 0.3083E0 FGFR1, FGFR3, FLT1, PDGFRA, PDGFRB ERK1 and ERK2 cascade, MAPK cascade, angiogenesis, apoptotic process, astrocyte differentiation, calcium ion import, canonical Wnt receptor signaling pathway, cardiac muscle cell proliferation, cell cycle, cell development, cell differentiation, cell migration, cell proliferation, chemotaxis, developmental growth, endothelial cell proliferation, epithelial cell proliferation, lipid metabolic process, mesenchymal cell proliferation, mitosis, neuron projection development, phosphatidylinositol 3-kinase cascade, platelet activation, protein phosphorylation, protein ubiquitination, smoothened signaling pathway, specification of organ identity, transcription from RNA polymerase II promoter, tyrosine phosphorylation of Stat1 protein, tyrosine phosphorylation of Stat3 protein, vascular endothelial growth factor receptor signaling pathway ENSG00000068078, ENSG00000077782, ENSG00000102755, ENSG00000113721, ENSG00000134853
Sorafenib 371 19 0.3027E0 FGFR1, FLT1, FLT3, KDR, KIT, PDGFRB, RET B cell differentiation, ERK1 and ERK2 cascade, MAPK cascade, angiogenesis, apoptotic process, behavior, calcium ion import, cardiac muscle cell proliferation, cell cycle, cell differentiation, cell migration, cell proliferation, chemotaxis, endothelial cell migration, endothelial cell proliferation, focal adhesion assembly, gene expression, lipid metabolic process, mesenchymal cell proliferation, metanephric glomerulus development, neuron projection development, phosphatidylinositol 3-kinase cascade, positive chemotaxis, programmed cell death, protein phosphorylation, specification of organ identity, transcription from RNA polymerase II promoter, tyrosine phosphorylation of Stat1 protein, tyrosine phosphorylation of Stat3 protein, tyrosine phosphorylation of Stat5 protein, vascular endothelial growth factor receptor signaling pathway ENSG00000077782, ENSG00000102755, ENSG00000113721, ENSG00000122025, ENSG00000128052, ENSG00000157404, ENSG00000165731
Nintedanib esylate 372 18 0.2904E0 FGFR1, FLT1, FLT3, KDR, PDGFRA, PDGFRB B cell differentiation, ERK1 and ERK2 cascade, MAPK cascade, angiogenesis, apoptotic process, behavior, calcium ion import, cardiac muscle cell proliferation, cell cycle, cell migration, cell proliferation, chemotaxis, endothelial cell migration, endothelial cell proliferation, focal adhesion assembly, lipid metabolic process, mesenchymal cell proliferation, neuron projection development, phosphatidylinositol 3-kinase cascade, platelet activation, positive chemotaxis, protein phosphorylation, specification of organ identity, transcription from RNA polymerase II promoter, vascular endothelial growth factor receptor signaling pathway ENSG00000077782, ENSG00000102755, ENSG00000113721, ENSG00000122025, ENSG00000128052, ENSG00000134853
Metoclopramide 318 72 0.2842E0 CHRM1, CYP17A1, DRD2, HTR4 cAMP metabolic process, cellular biosynthetic process, dopamine receptor signaling pathway, growth hormone secretion, hormone biosynthetic process, ion transport ENSG00000148795, ENSG00000149295, ENSG00000164270, ENSG00000168539
Abiraterone acetate, Galeterone, Liarozole fumarate, Liarozole hydrochloride, Mitotane, Orteronel, Progesterone 340 50 0.2741E0 CYP17A1 cellular biosynthetic process, hormone biosynthetic process ENSG00000148795
Dexamethasone 340 50 0.2741E0 ANXA1, CYP17A1, NOS2 acute inflammatory response, apoptotic process, cellular biosynthetic process, gene expression, hormone biosynthetic process, killing of cells of other organism, leukocyte mediated cytotoxicity, prostaglandin biosynthetic process, protein catabolic process, protein secretion, response to external stimulus, vasodilation ENSG00000007171, ENSG00000135046, ENSG00000148795
Palbociclib 315 75 0.2718E0 CDK4, CDK6 apoptotic process, cellular senescence, fibroblast proliferation, translation ENSG00000105810, ENSG00000135446
Hydroxychloroquine 374 16 0.2641E0 TLR7, TLR9 JNK cascade, cellular biosynthetic process, chemokine production, inflammatory response, innate immune response, interferon-gamma biosynthetic process, interleukin-10 production, interleukin-12 production, interleukin-6 production, macromolecule biosynthetic process, protein phosphorylation, response to external stimulus, transcription from RNA polymerase II promoter ENSG00000196664, ENSG00000239732
Lonafarnib, Tipifarnib 320 70 0.2587E0 FNTB cell cycle, cell proliferation, cellular process, fibroblast proliferation ENSG00000257365
Cilengitide 310 80 0.2432E0 ITGAV, ITGB3 apoptotic process, cell adhesion, cell migration, cellular component organization, endothelial cell migration, endothelial cell proliferation, lipid storage, lipid transport, macrophage derived foam cell differentiation, osteoblast proliferation, peptidyl-tyrosine phosphorylation, phagocytosis, vascular endothelial growth factor receptor signaling pathway ENSG00000138448, ENSG00000259207
Pentosan Polysulfate 342 48 0.2329E0 FGF1, FGF4 ERK1 and ERK2 cascade, apoptotic process, cell differentiation, cell division, cell proliferation, intracellular protein kinase cascade, protein phosphorylation, transcription from RNA polymerase II promoter ENSG00000075388, ENSG00000113578
Sunitinib 347 43 0.2289E0 CSF1, FLT1, FLT3, KDR, KIT, PDGFRA, PDGFRB, RET B cell differentiation, ERK1 and ERK2 cascade, MAPK cascade, angiogenesis, behavior, calcium ion import, cell differentiation, cell migration, cell proliferation, chemotaxis, endothelial cell migration, endothelial cell proliferation, focal adhesion assembly, gene expression, lipid metabolic process, mesenchymal cell proliferation, metanephric glomerulus development, monocyte differentiation, phosphatidylinositol 3-kinase cascade, platelet activation, positive chemotaxis, programmed cell death, protein phosphorylation, tyrosine phosphorylation of Stat1 protein, tyrosine phosphorylation of Stat3 protein, tyrosine phosphorylation of Stat5 protein, vascular endothelial growth factor receptor signaling pathway ENSG00000102755, ENSG00000113721, ENSG00000122025, ENSG00000128052, ENSG00000134853, ENSG00000157404, ENSG00000165731, ENSG00000184371
Calcium valproate, Divalproex sodium, Sodium valproate 319 71 0.2271E0 CACNA1H, HDAC10, HDAC2, HDAC3, HDAC5, HDAC6, HDAC7, HDAC8 JNK cascade, acrosome reaction, apoptotic process, canonical Wnt receptor signaling pathway, cardiac muscle cell proliferation, cell cycle, cell development, cell migration involved in sprouting angiogenesis, cell proliferation, cellular protein metabolic process, collagen biosynthetic process, epithelial cell migration, interleukin-2 production, microtubule depolymerization, myotube differentiation, neuron projection development, osteoblast differentiation, proteolysis, receptor biosynthetic process, signal transduction, transcription from RNA polymerase II promoter, transcription, DNA-dependent ENSG00000061273, ENSG00000094631, ENSG00000100429, ENSG00000108840, ENSG00000147099, ENSG00000171720, ENSG00000196557, ENSG00000196591
Valproic acid 319 71 0.2271E0 CACNA1H, HDAC10, HDAC2, HDAC3, HDAC5, HDAC6, HDAC7, HDAC8, SLC22A5 JNK cascade, acrosome reaction, apoptotic process, canonical Wnt receptor signaling pathway, cardiac muscle cell proliferation, cell cycle, cell development, cell migration involved in sprouting angiogenesis, cell proliferation, cellular protein metabolic process, collagen biosynthetic process, epithelial cell migration, interleukin-2 production, intestinal epithelial structure maintenance, microtubule depolymerization, myotube differentiation, neuron projection development, osteoblast differentiation, proteolysis, receptor biosynthetic process, signal transduction, transcription from RNA polymerase II promoter, transcription, DNA-dependent ENSG00000061273, ENSG00000094631, ENSG00000100429, ENSG00000108840, ENSG00000147099, ENSG00000171720, ENSG00000196557, ENSG00000196591, ENSG00000197375
Vorinostat 319 71 0.2271E0 HDAC2, HDAC3, HDAC6 JNK cascade, apoptotic process, canonical Wnt receptor signaling pathway, cardiac muscle cell proliferation, cell cycle, cell development, cell proliferation, cellular protein metabolic process, collagen biosynthetic process, epithelial cell migration, microtubule depolymerization, neuron projection development, proteolysis, receptor biosynthetic process, signal transduction, transcription from RNA polymerase II promoter, transcription, DNA-dependent ENSG00000094631, ENSG00000171720, ENSG00000196591
Abexinostat, Belinostat, Panobinostat, Romidepsin 319 71 0.2271E0 HDAC10, HDAC2, HDAC3, HDAC5, HDAC6, HDAC7, HDAC8 JNK cascade, apoptotic process, canonical Wnt receptor signaling pathway, cardiac muscle cell proliferation, cell cycle, cell development, cell migration involved in sprouting angiogenesis, cell proliferation, cellular protein metabolic process, collagen biosynthetic process, epithelial cell migration, interleukin-2 production, microtubule depolymerization, myotube differentiation, neuron projection development, osteoblast differentiation, proteolysis, receptor biosynthetic process, signal transduction, transcription from RNA polymerase II promoter, transcription, DNA-dependent ENSG00000061273, ENSG00000094631, ENSG00000100429, ENSG00000108840, ENSG00000147099, ENSG00000171720, ENSG00000196591
Amlexanox 344 46 0.2244E0 FGF1 intracellular protein kinase cascade ENSG00000113578
Ronacaleret hydrochloride 339 51 0.2171E0 CASR cell proliferation, cellular process, gene expression ENSG00000036828
Linifanib 348 42 0.2166E0 CSF1, FLT1, KDR, PDGFRA, PDGFRB ERK1 and ERK2 cascade, MAPK cascade, angiogenesis, behavior, calcium ion import, cell migration, cell proliferation, chemotaxis, endothelial cell migration, endothelial cell proliferation, focal adhesion assembly, lipid metabolic process, mesenchymal cell proliferation, monocyte differentiation, phosphatidylinositol 3-kinase cascade, platelet activation, positive chemotaxis, protein phosphorylation, vascular endothelial growth factor receptor signaling pathway ENSG00000102755, ENSG00000113721, ENSG00000128052, ENSG00000134853, ENSG00000184371
Axitinib, Vatalanib 375 15 0.2163E0 FLT1, KDR, KIT, PDGFRB ERK1 and ERK2 cascade, MAPK cascade, angiogenesis, behavior, calcium ion import, cell differentiation, cell migration, cell proliferation, chemotaxis, endothelial cell migration, endothelial cell proliferation, focal adhesion assembly, gene expression, lipid metabolic process, mesenchymal cell proliferation, phosphatidylinositol 3-kinase cascade, positive chemotaxis, programmed cell death, protein phosphorylation, tyrosine phosphorylation of Stat1 protein, tyrosine phosphorylation of Stat3 protein, tyrosine phosphorylation of Stat5 protein, vascular endothelial growth factor receptor signaling pathway ENSG00000102755, ENSG00000113721, ENSG00000128052, ENSG00000157404
Motesanib 375 15 0.2163E0 FLT1, KDR, KIT, PDGFRA, PDGFRB, RET ERK1 and ERK2 cascade, MAPK cascade, angiogenesis, behavior, calcium ion import, cell differentiation, cell migration, cell proliferation, chemotaxis, endothelial cell migration, endothelial cell proliferation, focal adhesion assembly, gene expression, lipid metabolic process, mesenchymal cell proliferation, metanephric glomerulus development, phosphatidylinositol 3-kinase cascade, platelet activation, positive chemotaxis, programmed cell death, protein phosphorylation, tyrosine phosphorylation of Stat1 protein, tyrosine phosphorylation of Stat3 protein, tyrosine phosphorylation of Stat5 protein, vascular endothelial growth factor receptor signaling pathway ENSG00000102755, ENSG00000113721, ENSG00000128052, ENSG00000134853, ENSG00000157404, ENSG00000165731
Toceranib 375 15 0.2163E0 FLT1, FLT3, KDR, KIT, PDGFRA, PDGFRB B cell differentiation, ERK1 and ERK2 cascade, MAPK cascade, angiogenesis, behavior, calcium ion import, cell differentiation, cell migration, cell proliferation, chemotaxis, endothelial cell migration, endothelial cell proliferation, focal adhesion assembly, gene expression, lipid metabolic process, mesenchymal cell proliferation, phosphatidylinositol 3-kinase cascade, platelet activation, positive chemotaxis, programmed cell death, protein phosphorylation, tyrosine phosphorylation of Stat1 protein, tyrosine phosphorylation of Stat3 protein, tyrosine phosphorylation of Stat5 protein, vascular endothelial growth factor receptor signaling pathway ENSG00000102755, ENSG00000113721, ENSG00000122025, ENSG00000128052, ENSG00000134853, ENSG00000157404
Cediranib 375 15 0.2163E0 FLT1, KDR, KIT, PDGFRA, PDGFRB ERK1 and ERK2 cascade, MAPK cascade, angiogenesis, behavior, calcium ion import, cell differentiation, cell migration, cell proliferation, chemotaxis, endothelial cell migration, endothelial cell proliferation, focal adhesion assembly, gene expression, lipid metabolic process, mesenchymal cell proliferation, phosphatidylinositol 3-kinase cascade, platelet activation, positive chemotaxis, programmed cell death, protein phosphorylation, tyrosine phosphorylation of Stat1 protein, tyrosine phosphorylation of Stat3 protein, tyrosine phosphorylation of Stat5 protein, vascular endothelial growth factor receptor signaling pathway ENSG00000102755, ENSG00000113721, ENSG00000128052, ENSG00000134853, ENSG00000157404
Tivozanib 377 13 0.1996E0 FLT1, KDR ERK1 and ERK2 cascade, MAPK cascade, angiogenesis, behavior, cell migration, cell proliferation, endothelial cell migration, endothelial cell proliferation, focal adhesion assembly, lipid metabolic process, mesenchymal cell proliferation, phosphatidylinositol 3-kinase cascade, positive chemotaxis, protein phosphorylation, vascular endothelial growth factor receptor signaling pathway ENSG00000102755, ENSG00000128052
Ilorasertib 377 13 0.1974E0 AURKB, AURKC, FLT1, PDGFRA, PDGFRB, SRC MAPK cascade, angiogenesis, calcium ion import, cell migration, cell proliferation, chemotaxis, cytokinesis, integrin activation, lipid metabolic process, phosphatidylinositol 3-kinase cascade, platelet activation, protein phosphorylation, transcription from RNA polymerase II promoter, vascular endothelial growth factor receptor signaling pathway ENSG00000102755, ENSG00000105146, ENSG00000113721, ENSG00000134853, ENSG00000178999, ENSG00000197122
Sotrastaurin 313 77 0.1655E0 PRKCD, PRKCE, PRKCQ I-kappaB kinase/NF-kappaB cascade, MAPK cascade, T cell apoptotic process, T cell proliferation, T-helper 17 type immune response, actin filament polymerization, apoptotic process, cellular biosynthetic process, cellular carbohydrate metabolic process, cellular glucuronidation, ceramide biosynthetic process, cytokinesis, epithelial cell migration, fibroblast migration, innate immune response, insulin receptor signaling pathway, insulin secretion, interleukin-2 biosynthetic process, interleukin-4 production, macromolecule biosynthetic process, platelet aggregation, sequestering of calcium ion, superoxide anion generation, synaptic transmission, GABAergic, wound healing ENSG00000065675, ENSG00000163932, ENSG00000171132
Talarozole 347 43 0.1526E0 CYP26A1, CYP26B1, CYP26C1 gene expression, retinoic acid receptor signaling pathway ENSG00000003137, ENSG00000095596, ENSG00000187553
Ibipinabant, Rimonabant 376 14 0.1426E0 CNR1 amine transport, apoptotic process, fever generation, neuron projection development, response to external stimulus ENSG00000118432
Ponatinib 366 24 0.1314E0 ABL1, BCR, CSK, FGFR1, FGFR3, FLT3, KDR, KIT, LYN, PDGFRA, RET, SRC B cell differentiation, ERK1 and ERK2 cascade, Golgi to plasma membrane protein transport, MAPK cascade, angiogenesis, apoptotic process, astrocyte differentiation, behavior, canonical Wnt receptor signaling pathway, cardiac muscle cell proliferation, cell cycle, cell development, cell differentiation, cell migration, cell proliferation, cellular component organization, developmental growth, endothelial cell migration, endothelial cell proliferation, epithelial cell proliferation, focal adhesion assembly, gene expression, immune response, inflammatory response, integrin activation, lipid metabolic process, mesenchymal cell proliferation, metanephric glomerulus development, mitosis, muscle cell differentiation, neuron projection development, neutrophil degranulation, peptidyl-tyrosine phosphorylation, phagocytosis, phosphatidylinositol 3-kinase cascade, platelet activation, positive chemotaxis, programmed cell death, protein phosphorylation, protein ubiquitination, response to external stimulus, smoothened signaling pathway, specification of organ identity, toll-like receptor 2 signaling pathway, transcription from RNA polymerase II promoter, tyrosine phosphorylation of STAT protein, tyrosine phosphorylation of Stat1 protein, tyrosine phosphorylation of Stat3 protein, tyrosine phosphorylation of Stat5 protein ENSG00000068078, ENSG00000077782, ENSG00000097007, ENSG00000103653, ENSG00000122025, ENSG00000128052, ENSG00000134853, ENSG00000157404, ENSG00000165731, ENSG00000186716, ENSG00000197122, ENSG00000254087
Bortezomib 155 235 0.1267E0 PSMB1, PSMD1, PSMD2 G1/S transition of mitotic cell cycle, cell cycle arrest, protein ubiquitination ENSG00000008018, ENSG00000173692, ENSG00000175166
Trebananib 341 49 0.1261E0 ANGPT1, ANGPT2 ERK1 and ERK2 cascade, angiogenesis, behavior, blood vessel endothelial cell migration, cell adhesion, cellular component organization, peptidyl-serine phosphorylation, peptidyl-tyrosine phosphorylation, phosphatidylinositol 3-kinase cascade, positive chemotaxis, protein kinase B signaling cascade, protein ubiquitination, receptor internalization ENSG00000091879, ENSG00000154188
Asenapine maleate 312 78 0.1257E0 ADRA1A, ADRA1B, ADRA1D, ADRA2A, ADRA2B, ADRB1, DRD1, DRD2, DRD3, DRD4, HRH2, HTR1A, HTR1B, HTR1F, HTR2A, HTR2B, HTR2C, HTR6 G-protein coupled receptor signaling pathway, I-kappaB kinase/NF-kappaB cascade, MAPK cascade, adrenergic receptor signaling pathway, amine transport, apoptotic process, autophagy, cAMP biosynthetic process, cAMP metabolic process, calcium ion-dependent exocytosis, cardiac muscle contraction, cell division, cell growth involved in cardiac muscle cell development, cell migration, cell proliferation, cellular carbohydrate metabolic process, cellular catabolic process, cellular process, cytokine secretion, diacylglycerol biosynthetic process, dopamine receptor signaling pathway, dopamine uptake involved in synaptic transmission, endothelial cell proliferation, epidermal growth factor receptor signaling pathway, glycogen catabolic process, growth hormone secretion, heart contraction, inositol trisphosphate biosynthetic process, lipid catabolic process, locomotion, multicellular organism growth, multicellular organismal metabolic process, muscle organ development, neuron differentiation, oligodendrocyte differentiation, peptidyl-tyrosine phosphorylation, potassium ion transport, protein phosphorylation, protein secretion, response to external stimulus, saliva secretion, sequestering of calcium ion, smooth muscle contraction, synaptic transmission, synaptic transmission, GABAergic, synaptic transmission, glutamatergic, vasoconstriction ENSG00000043591, ENSG00000069696, ENSG00000102468, ENSG00000113749, ENSG00000120907, ENSG00000135312, ENSG00000135914, ENSG00000147246, ENSG00000149295, ENSG00000150594, ENSG00000151577, ENSG00000158748, ENSG00000170214, ENSG00000171873, ENSG00000178394, ENSG00000179097, ENSG00000184845, ENSG00000222040
Foretinib, Golvatinib 371 19 0.1099E0 KDR, MET ERK1 and ERK2 cascade, MAPK cascade, angiogenesis, behavior, endothelial cell migration, endothelial cell proliferation, focal adhesion assembly, mesenchymal cell proliferation, phosphatidylinositol 3-kinase cascade, positive chemotaxis, protein phosphorylation, transcription from RNA polymerase II promoter ENSG00000105976, ENSG00000128052
Clozapine, Olanzapine 341 49 0.1067E0 ADRA1A, ADRA1B, ADRA1D, ADRA2A, ADRA2B, CHRM1, CHRM2, DRD1, DRD2, DRD3, DRD4, HTR1A, HTR1B, HTR2A, HTR2C, HTR6 G-protein coupled receptor signaling pathway, MAPK cascade, adrenergic receptor signaling pathway, amine transport, cAMP biosynthetic process, cAMP metabolic process, calcium ion-dependent exocytosis, cardiac muscle contraction, cell migration, cell proliferation, cellular carbohydrate metabolic process, cellular catabolic process, cellular process, diacylglycerol biosynthetic process, dopamine receptor signaling pathway, dopamine uptake involved in synaptic transmission, epidermal growth factor receptor signaling pathway, glycogen catabolic process, growth hormone secretion, heart contraction, inositol trisphosphate biosynthetic process, ion transport, lipid catabolic process, locomotion, neuron differentiation, oligodendrocyte differentiation, peptidyl-tyrosine phosphorylation, potassium ion transport, protein phosphorylation, protein secretion, response to external stimulus, sequestering of calcium ion, synaptic transmission, synaptic transmission, GABAergic, synaptic transmission, glutamatergic, vasoconstriction ENSG00000069696, ENSG00000102468, ENSG00000120907, ENSG00000135312, ENSG00000147246, ENSG00000149295, ENSG00000150594, ENSG00000151577, ENSG00000158748, ENSG00000168539, ENSG00000170214, ENSG00000171873, ENSG00000178394, ENSG00000181072, ENSG00000184845, ENSG00000222040
Quetiapine fumarate 341 49 0.1067E0 ADRA1A, ADRA1B, ADRA1D, ADRA2A, ADRA2B, CHRM1, CHRM2, DRD1, DRD2, DRD3, DRD4, HTR1A, HTR2A, HTR2C, HTR6 MAPK cascade, adrenergic receptor signaling pathway, amine transport, cAMP biosynthetic process, cAMP metabolic process, calcium ion-dependent exocytosis, cardiac muscle contraction, cell migration, cell proliferation, cellular carbohydrate metabolic process, cellular catabolic process, cellular process, diacylglycerol biosynthetic process, dopamine receptor signaling pathway, dopamine uptake involved in synaptic transmission, epidermal growth factor receptor signaling pathway, glycogen catabolic process, growth hormone secretion, heart contraction, inositol trisphosphate biosynthetic process, ion transport, lipid catabolic process, locomotion, neuron differentiation, oligodendrocyte differentiation, peptidyl-tyrosine phosphorylation, potassium ion transport, protein phosphorylation, protein secretion, response to external stimulus, sequestering of calcium ion, synaptic transmission, synaptic transmission, glutamatergic, vasoconstriction ENSG00000069696, ENSG00000102468, ENSG00000120907, ENSG00000147246, ENSG00000149295, ENSG00000150594, ENSG00000151577, ENSG00000158748, ENSG00000168539, ENSG00000170214, ENSG00000171873, ENSG00000178394, ENSG00000181072, ENSG00000184845, ENSG00000222040
Ziprasidone 338 52 0.1044E0 ADRA1A, ADRA1B, ADRA2A, ADRA2B, CHRM1, CHRM2, DRD1, DRD2, DRD3, DRD4, HTR1A, HTR1B, HTR2A, HTR2B, HTR2C, HTR6 G-protein coupled receptor signaling pathway, I-kappaB kinase/NF-kappaB cascade, MAPK cascade, adrenergic receptor signaling pathway, amine transport, apoptotic process, autophagy, cAMP biosynthetic process, cAMP metabolic process, calcium ion-dependent exocytosis, cardiac muscle contraction, cell division, cell migration, cell proliferation, cellular carbohydrate metabolic process, cellular catabolic process, cellular process, cytokine secretion, diacylglycerol biosynthetic process, dopamine receptor signaling pathway, dopamine uptake involved in synaptic transmission, endothelial cell proliferation, epidermal growth factor receptor signaling pathway, glycogen catabolic process, growth hormone secretion, heart contraction, inositol trisphosphate biosynthetic process, ion transport, lipid catabolic process, locomotion, neuron differentiation, oligodendrocyte differentiation, peptidyl-tyrosine phosphorylation, potassium ion transport, protein phosphorylation, protein secretion, response to external stimulus, sequestering of calcium ion, synaptic transmission, synaptic transmission, GABAergic, synaptic transmission, glutamatergic, vasoconstriction ENSG00000069696, ENSG00000102468, ENSG00000120907, ENSG00000135312, ENSG00000135914, ENSG00000147246, ENSG00000149295, ENSG00000150594, ENSG00000151577, ENSG00000158748, ENSG00000168539, ENSG00000170214, ENSG00000178394, ENSG00000181072, ENSG00000184845, ENSG00000222040
Tivantinib 373 17 0.1033E0 MET MAPK cascade, protein phosphorylation, transcription from RNA polymerase II promoter ENSG00000105976
Levomepromazine 340 50 0.1013E0 ADRA1A, ADRA1B, ADRA1D, ADRA2A, ADRA2B, CHRM1, CHRM2, DRD1, DRD2, DRD3, DRD4, HTR2A, HTR2B, HTR2C G-protein coupled receptor signaling pathway, I-kappaB kinase/NF-kappaB cascade, MAPK cascade, adrenergic receptor signaling pathway, amine transport, apoptotic process, autophagy, cAMP biosynthetic process, cAMP metabolic process, calcium ion-dependent exocytosis, cardiac muscle contraction, cell division, cell migration, cell proliferation, cellular carbohydrate metabolic process, cellular catabolic process, cellular process, cytokine secretion, diacylglycerol biosynthetic process, dopamine receptor signaling pathway, dopamine uptake involved in synaptic transmission, endothelial cell proliferation, epidermal growth factor receptor signaling pathway, glycogen catabolic process, growth hormone secretion, heart contraction, inositol trisphosphate biosynthetic process, ion transport, lipid catabolic process, locomotion, neuron differentiation, oligodendrocyte differentiation, peptidyl-tyrosine phosphorylation, potassium ion transport, protein phosphorylation, protein secretion, response to external stimulus, sequestering of calcium ion, synaptic transmission, synaptic transmission, glutamatergic, vasoconstriction ENSG00000069696, ENSG00000102468, ENSG00000120907, ENSG00000135914, ENSG00000147246, ENSG00000149295, ENSG00000150594, ENSG00000151577, ENSG00000168539, ENSG00000170214, ENSG00000171873, ENSG00000181072, ENSG00000184845, ENSG00000222040
Lenalidomide 361 29 0.097E0 CRBN, TNF, TNFSF11 ERK1 and ERK2 cascade, I-kappaB kinase/NF-kappaB cascade, JNK cascade, L-glutamate transport, T cell activation, amine transport, apoptotic process, bone resorption, cell proliferation, cellular catabolic process, cytokine secretion, fat cell differentiation, fever generation, glucose import, growth of symbiont in host, hair follicle development, heterotypic cell-cell adhesion, interferon-gamma production, interleukin-6 production, ion transmembrane transport, lipid storage, membrane protein ectodomain proteolysis, mitosis, necroptosis, neuron apoptotic process, nitric oxide biosynthetic process, osteoblast differentiation, osteoclast differentiation, peptidyl-serine phosphorylation, podosome assembly, protein catabolic process, protein kinase B signaling cascade, protein localization to cell surface, protein phosphorylation, response to external stimulus, smooth muscle cell proliferation, synaptic transmission, transcription from RNA polymerase II promoter, translational initiation, viral genome replication ENSG00000113851, ENSG00000120659, ENSG00000232810
Paliperidone 343 47 0.0951E0 ADRA1A, ADRA1B, ADRA2A, ADRA2B, DRD1, DRD2, DRD3, DRD4, HTR1A, HTR2A, HTR2C MAPK cascade, adrenergic receptor signaling pathway, amine transport, cAMP biosynthetic process, calcium ion-dependent exocytosis, cardiac muscle contraction, cell migration, cell proliferation, cellular carbohydrate metabolic process, cellular catabolic process, cellular process, diacylglycerol biosynthetic process, dopamine receptor signaling pathway, dopamine uptake involved in synaptic transmission, epidermal growth factor receptor signaling pathway, glycogen catabolic process, growth hormone secretion, heart contraction, inositol trisphosphate biosynthetic process, lipid catabolic process, locomotion, neuron differentiation, oligodendrocyte differentiation, peptidyl-tyrosine phosphorylation, potassium ion transport, protein phosphorylation, protein secretion, response to external stimulus, sequestering of calcium ion, synaptic transmission, synaptic transmission, glutamatergic, vasoconstriction ENSG00000069696, ENSG00000102468, ENSG00000120907, ENSG00000147246, ENSG00000149295, ENSG00000150594, ENSG00000151577, ENSG00000170214, ENSG00000178394, ENSG00000184845, ENSG00000222040
Chlorpromazine 341 49 0.0937E0 ADRA1A, ADRA1B, ADRA2A, ADRA2B, CHRM1, CHRM2, DRD1, DRD2, HTR1A, HTR2A, HTR2B, HTR2C G-protein coupled receptor signaling pathway, I-kappaB kinase/NF-kappaB cascade, MAPK cascade, adrenergic receptor signaling pathway, amine transport, apoptotic process, autophagy, cAMP biosynthetic process, cAMP metabolic process, calcium ion-dependent exocytosis, cardiac muscle contraction, cell division, cell migration, cell proliferation, cellular carbohydrate metabolic process, cellular catabolic process, cellular process, cytokine secretion, diacylglycerol biosynthetic process, dopamine receptor signaling pathway, endothelial cell proliferation, epidermal growth factor receptor signaling pathway, glycogen catabolic process, growth hormone secretion, heart contraction, inositol trisphosphate biosynthetic process, ion transport, lipid catabolic process, locomotion, neuron differentiation, peptidyl-tyrosine phosphorylation, potassium ion transport, protein phosphorylation, response to external stimulus, sequestering of calcium ion, synaptic transmission, synaptic transmission, glutamatergic, vasoconstriction ENSG00000102468, ENSG00000120907, ENSG00000135914, ENSG00000147246, ENSG00000149295, ENSG00000150594, ENSG00000168539, ENSG00000170214, ENSG00000178394, ENSG00000181072, ENSG00000184845, ENSG00000222040
Mianserin 335 55 0.0936E0 ADRA1A, ADRA1B, ADRA1D, ADRA2A, ADRA2B, HTR1A, HTR1B, HTR1F, HTR2A, HTR2B, HTR2C G-protein coupled receptor signaling pathway, I-kappaB kinase/NF-kappaB cascade, MAPK cascade, adrenergic receptor signaling pathway, amine transport, apoptotic process, autophagy, cAMP biosynthetic process, cAMP metabolic process, calcium ion-dependent exocytosis, cardiac muscle contraction, cell division, cell proliferation, cellular carbohydrate metabolic process, cellular catabolic process, cellular process, cytokine secretion, diacylglycerol biosynthetic process, endothelial cell proliferation, epidermal growth factor receptor signaling pathway, glycogen catabolic process, heart contraction, inositol trisphosphate biosynthetic process, lipid catabolic process, locomotion, neuron differentiation, peptidyl-tyrosine phosphorylation, potassium ion transport, protein phosphorylation, sequestering of calcium ion, synaptic transmission, GABAergic, synaptic transmission, glutamatergic, vasoconstriction ENSG00000102468, ENSG00000120907, ENSG00000135312, ENSG00000135914, ENSG00000147246, ENSG00000150594, ENSG00000170214, ENSG00000171873, ENSG00000178394, ENSG00000179097, ENSG00000222040
Brivanib, Brivanib alaninate 384 6 0.093E0 FGFR1, KDR ERK1 and ERK2 cascade, MAPK cascade, angiogenesis, apoptotic process, behavior, cardiac muscle cell proliferation, cell cycle, endothelial cell migration, endothelial cell proliferation, focal adhesion assembly, mesenchymal cell proliferation, neuron projection development, phosphatidylinositol 3-kinase cascade, positive chemotaxis, protein phosphorylation, specification of organ identity, transcription from RNA polymerase II promoter ENSG00000077782, ENSG00000128052
Dasatinib 366 24 0.0882E0 ABL1, EPHA2, KIT, PDGFRB, SRC, STAT5B, YES1 MAPK cascade, T cell activation, apoptotic process, calcium ion import, cell differentiation, cell proliferation, chemotaxis, establishment of protein localization to plasma membrane, gene expression, immune response, integrin activation, lipid metabolic process, muscle cell differentiation, natural killer cell differentiation, natural killer cell mediated cytotoxicity, peptidyl-tyrosine phosphorylation, phosphatidylinositol 3-kinase cascade, programmed cell death, protein kinase B signaling cascade, protein phosphorylation, tyrosine phosphorylation of Stat1 protein, tyrosine phosphorylation of Stat3 protein, tyrosine phosphorylation of Stat5 protein ENSG00000097007, ENSG00000113721, ENSG00000142627, ENSG00000157404, ENSG00000173757, ENSG00000176105, ENSG00000197122
Doxepin 343 47 0.0867E0 ADRA1A, ADRA1B, ADRA1D, ADRA2A, ADRA2B, CHRM1, CHRM2, DRD2, HRH2, HTR1A, HTR2A, HTR2B, HTR2C G-protein coupled receptor signaling pathway, I-kappaB kinase/NF-kappaB cascade, MAPK cascade, adrenergic receptor signaling pathway, amine transport, apoptotic process, autophagy, cAMP metabolic process, calcium ion-dependent exocytosis, cardiac muscle contraction, cell division, cell proliferation, cellular carbohydrate metabolic process, cellular catabolic process, cellular process, cytokine secretion, diacylglycerol biosynthetic process, dopamine receptor signaling pathway, endothelial cell proliferation, epidermal growth factor receptor signaling pathway, glycogen catabolic process, growth hormone secretion, heart contraction, inositol trisphosphate biosynthetic process, ion transport, lipid catabolic process, locomotion, neuron differentiation, peptidyl-tyrosine phosphorylation, potassium ion transport, protein phosphorylation, sequestering of calcium ion, synaptic transmission, glutamatergic, vasoconstriction ENSG00000102468, ENSG00000113749, ENSG00000120907, ENSG00000135914, ENSG00000147246, ENSG00000149295, ENSG00000150594, ENSG00000168539, ENSG00000170214, ENSG00000171873, ENSG00000178394, ENSG00000181072, ENSG00000222040
Imatinib 380 10 0.0841E0 ABL1, CSF1R, KIT, NTRK1, PDGFRA, PDGFRB ERK1 and ERK2 cascade, MAPK cascade, Ras protein signal transduction, angiogenesis, apoptotic process, cAMP biosynthetic process, calcium ion import, cell differentiation, cell migration, cell proliferation, chemotaxis, gene expression, immune response, lipid metabolic process, muscle cell differentiation, neuron apoptotic process, neuron projection development, peptidyl-tyrosine phosphorylation, phosphatidylinositol 3-kinase cascade, platelet activation, programmed cell death, protein phosphorylation, synaptic transmission, glutamatergic, tyrosine phosphorylation of Stat1 protein, tyrosine phosphorylation of Stat3 protein, tyrosine phosphorylation of Stat5 protein ENSG00000097007, ENSG00000113721, ENSG00000134853, ENSG00000157404, ENSG00000182578, ENSG00000198400
Chlorpromazine tannate 344 46 0.0793E0 ADRA2A, ADRA2B, CHRM1, CHRM2, DRD2, HTR2A, HTR2B, HTR2C G-protein coupled receptor signaling pathway, I-kappaB kinase/NF-kappaB cascade, MAPK cascade, adrenergic receptor signaling pathway, amine transport, apoptotic process, autophagy, cAMP metabolic process, calcium ion-dependent exocytosis, cell division, cell proliferation, cellular carbohydrate metabolic process, cytokine secretion, diacylglycerol biosynthetic process, dopamine receptor signaling pathway, endothelial cell proliferation, epidermal growth factor receptor signaling pathway, growth hormone secretion, inositol trisphosphate biosynthetic process, ion transport, lipid catabolic process, locomotion, neuron differentiation, peptidyl-tyrosine phosphorylation, potassium ion transport, protein phosphorylation, sequestering of calcium ion, synaptic transmission, glutamatergic, vasoconstriction ENSG00000102468, ENSG00000135914, ENSG00000147246, ENSG00000149295, ENSG00000150594, ENSG00000168539, ENSG00000181072, ENSG00000222040
Aripiprazole 367 23 0.0777E0 ADRA1A, ADRA1B, ADRA2A, ADRA2B, CHRM1, CHRM2, DRD1, DRD2, DRD3, DRD4, HTR1A, HTR1B, HTR2A, HTR2C, HTR6 G-protein coupled receptor signaling pathway, MAPK cascade, adrenergic receptor signaling pathway, amine transport, cAMP biosynthetic process, cAMP metabolic process, calcium ion-dependent exocytosis, cardiac muscle contraction, cell migration, cell proliferation, cellular carbohydrate metabolic process, cellular catabolic process, cellular process, diacylglycerol biosynthetic process, dopamine receptor signaling pathway, dopamine uptake involved in synaptic transmission, epidermal growth factor receptor signaling pathway, glycogen catabolic process, growth hormone secretion, heart contraction, inositol trisphosphate biosynthetic process, ion transport, lipid catabolic process, locomotion, neuron differentiation, oligodendrocyte differentiation, peptidyl-tyrosine phosphorylation, potassium ion transport, protein phosphorylation, protein secretion, response to external stimulus, sequestering of calcium ion, synaptic transmission, synaptic transmission, GABAergic, synaptic transmission, glutamatergic, vasoconstriction ENSG00000069696, ENSG00000102468, ENSG00000120907, ENSG00000135312, ENSG00000147246, ENSG00000149295, ENSG00000150594, ENSG00000151577, ENSG00000158748, ENSG00000168539, ENSG00000170214, ENSG00000178394, ENSG00000181072, ENSG00000184845, ENSG00000222040
Yohimbine 348 42 0.0773E0 ADRA2A, ADRA2B, DRD2, DRD3, HTR1A, HTR1B, HTR2A, HTR2C G-protein coupled receptor signaling pathway, MAPK cascade, adrenergic receptor signaling pathway, amine transport, cAMP biosynthetic process, calcium ion-dependent exocytosis, cell proliferation, cellular carbohydrate metabolic process, cellular process, diacylglycerol biosynthetic process, dopamine receptor signaling pathway, epidermal growth factor receptor signaling pathway, growth hormone secretion, inositol trisphosphate biosynthetic process, lipid catabolic process, locomotion, neuron differentiation, oligodendrocyte differentiation, peptidyl-tyrosine phosphorylation, potassium ion transport, protein phosphorylation, sequestering of calcium ion, synaptic transmission, GABAergic, synaptic transmission, glutamatergic, vasoconstriction ENSG00000102468, ENSG00000135312, ENSG00000147246, ENSG00000149295, ENSG00000150594, ENSG00000151577, ENSG00000178394, ENSG00000222040
Setiptiline 367 23 0.0766E0 ADRA1A, ADRA1B, ADRA1D, ADRA2A, ADRA2B, HTR2A, HTR2B, HTR2C G-protein coupled receptor signaling pathway, I-kappaB kinase/NF-kappaB cascade, MAPK cascade, adrenergic receptor signaling pathway, amine transport, apoptotic process, autophagy, calcium ion-dependent exocytosis, cardiac muscle contraction, cell division, cell proliferation, cellular carbohydrate metabolic process, cellular catabolic process, cellular process, cytokine secretion, diacylglycerol biosynthetic process, endothelial cell proliferation, epidermal growth factor receptor signaling pathway, glycogen catabolic process, heart contraction, inositol trisphosphate biosynthetic process, lipid catabolic process, locomotion, neuron differentiation, peptidyl-tyrosine phosphorylation, potassium ion transport, protein phosphorylation, sequestering of calcium ion, synaptic transmission, glutamatergic, vasoconstriction ENSG00000102468, ENSG00000120907, ENSG00000135914, ENSG00000147246, ENSG00000150594, ENSG00000170214, ENSG00000171873, ENSG00000222040
Mirtazapine 369 21 0.0692E0 ADRA2A, ADRA2B, HTR2A, HTR2B, HTR2C G-protein coupled receptor signaling pathway, I-kappaB kinase/NF-kappaB cascade, MAPK cascade, adrenergic receptor signaling pathway, amine transport, apoptotic process, autophagy, calcium ion-dependent exocytosis, cell division, cell proliferation, cellular carbohydrate metabolic process, cytokine secretion, diacylglycerol biosynthetic process, endothelial cell proliferation, epidermal growth factor receptor signaling pathway, inositol trisphosphate biosynthetic process, lipid catabolic process, locomotion, neuron differentiation, peptidyl-tyrosine phosphorylation, potassium ion transport, protein phosphorylation, sequestering of calcium ion, synaptic transmission, glutamatergic, vasoconstriction ENSG00000102468, ENSG00000135914, ENSG00000147246, ENSG00000150594, ENSG00000222040
Erismodegib, Saridegib, Vismodegib 383 7 0.0657E0 SMO apoptotic process, branching involved in ureteric bud morphogenesis, cell development, epithelial cell differentiation, epithelial cell proliferation, hair follicle development, mesenchymal cell proliferation, neuroblast proliferation, protein import into nucleus, smoothened signaling pathway, transcription from RNA polymerase II promoter ENSG00000128602
Aclarubicin, Amonafide, Amrubicin, Amsacrine, Berubicin hydrochloride, Ciprofloxacin, Crisnatol mesylate, Daunorubicin, Dexrazoxane, Doxorubicin, Enoxacin, Epirubicin, Etoposide, Fleroxacin, Idarubicin, Idronoxil, Ledoxantrone trihydrochloride, Levofloxacin, Lucanthone, Lucanthone hydrochloride, Mitoxantrone, Moxifloxacin, Pefloxacin, Pirarubicin, Pixantrone, Podofilox, Quarfloxin, Sedoxantrone trihydrochloride, Sobuzoxane, Teniposide, Trovafloxacin, Valrubicin, Vosaroxin 338 52 0.0657E0 TOP2A apoptotic process, transcription from RNA polymerase II promoter ENSG00000131747
Lomefloxacin, Norfloxacin, Ofloxacin, Sparfloxacin 338 52 0.0657E0 SLC22A5, TOP2A apoptotic process, intestinal epithelial structure maintenance, transcription from RNA polymerase II promoter ENSG00000131747, ENSG00000197375
Pegvisomant 328 62 0.0622E0 GHR, GLUL epithelial cell proliferation, insulin secretion, neuron death, synaptic transmission, glutamatergic ENSG00000112964, ENSG00000135821
Lestaurtinib 383 7 0.0602E0 FLT3, JAK2, NTRK1 B cell differentiation, ERK1 and ERK2 cascade, MAPK cascade, Ras protein signal transduction, angiogenesis, cAMP biosynthetic process, cell activation, cell proliferation, cell-substrate adhesion, growth hormone receptor signaling pathway, lipid metabolic process, neuron apoptotic process, neuron projection development, phosphatidylinositol 3-kinase cascade, programmed cell death, protein phosphorylation, synaptic transmission, glutamatergic ENSG00000096968, ENSG00000122025, ENSG00000198400
Abatacept 379 11 0.0593E0 CD80, CD86 T-helper 1 cell differentiation, T-helper 2 cell differentiation, alpha-beta T cell proliferation, cell proliferation, innate immune response, interleukin-2 biosynthetic process, transcription, DNA-dependent ENSG00000114013, ENSG00000121594
Iloperidone 352 38 0.0588E0 ADRA1A, DRD1, DRD2, DRD3, DRD4, HTR1A, HTR2A, HTR6 MAPK cascade, amine transport, cAMP biosynthetic process, cardiac muscle contraction, cell migration, cell proliferation, cellular carbohydrate metabolic process, cellular process, dopamine receptor signaling pathway, dopamine uptake involved in synaptic transmission, growth hormone secretion, inositol trisphosphate biosynthetic process, oligodendrocyte differentiation, potassium ion transport, protein phosphorylation, protein secretion, response to external stimulus, sequestering of calcium ion, synaptic transmission, synaptic transmission, glutamatergic, vasoconstriction ENSG00000069696, ENSG00000102468, ENSG00000120907, ENSG00000149295, ENSG00000151577, ENSG00000158748, ENSG00000178394, ENSG00000184845
Risperidone 353 37 0.0556E0 ADRA1A, ADRA1B, ADRA1D, ADRA2A, ADRA2B, DRD1, DRD2, DRD3, DRD4, HTR1A, HTR2A, HTR2C MAPK cascade, adrenergic receptor signaling pathway, amine transport, cAMP biosynthetic process, calcium ion-dependent exocytosis, cardiac muscle contraction, cell migration, cell proliferation, cellular carbohydrate metabolic process, cellular catabolic process, cellular process, diacylglycerol biosynthetic process, dopamine receptor signaling pathway, dopamine uptake involved in synaptic transmission, epidermal growth factor receptor signaling pathway, glycogen catabolic process, growth hormone secretion, heart contraction, inositol trisphosphate biosynthetic process, lipid catabolic process, locomotion, neuron differentiation, oligodendrocyte differentiation, peptidyl-tyrosine phosphorylation, potassium ion transport, protein phosphorylation, protein secretion, response to external stimulus, sequestering of calcium ion, synaptic transmission, synaptic transmission, glutamatergic, vasoconstriction ENSG00000069696, ENSG00000102468, ENSG00000120907, ENSG00000147246, ENSG00000149295, ENSG00000150594, ENSG00000151577, ENSG00000170214, ENSG00000171873, ENSG00000178394, ENSG00000184845, ENSG00000222040
Promazine hydrochloride, Propiomazine 353 37 0.0556E0 ADRA1A, ADRA1B, ADRA1D, CHRM1, CHRM2, DRD1, DRD2, DRD4, HTR2A, HTR2C MAPK cascade, amine transport, cAMP biosynthetic process, cAMP metabolic process, cardiac muscle contraction, cell migration, cell proliferation, cellular carbohydrate metabolic process, cellular catabolic process, cellular process, diacylglycerol biosynthetic process, dopamine receptor signaling pathway, dopamine uptake involved in synaptic transmission, glycogen catabolic process, growth hormone secretion, heart contraction, inositol trisphosphate biosynthetic process, ion transport, locomotion, potassium ion transport, protein phosphorylation, protein secretion, response to external stimulus, sequestering of calcium ion, synaptic transmission, synaptic transmission, glutamatergic, vasoconstriction ENSG00000069696, ENSG00000102468, ENSG00000120907, ENSG00000147246, ENSG00000149295, ENSG00000168539, ENSG00000170214, ENSG00000171873, ENSG00000181072, ENSG00000184845
Phenoxybenzamine 374 16 0.0511E0 ADRA1A, ADRA1B, ADRA1D, ADRA2A, ADRA2B, CALM1, CALM2, CALM3 MAPK cascade, adrenergic receptor signaling pathway, amine transport, calcium ion-dependent exocytosis, cardiac muscle contraction, cell proliferation, cellular catabolic process, cellular process, cyclic nucleotide metabolic process, epidermal growth factor receptor signaling pathway, glycogen catabolic process, heart contraction, lipid catabolic process, neuron differentiation, peptidyl-tyrosine phosphorylation, protein dephosphorylation, transport ENSG00000120907, ENSG00000143933, ENSG00000150594, ENSG00000160014, ENSG00000170214, ENSG00000171873, ENSG00000198668, ENSG00000222040
Phentolamine, Tolazoline 374 16 0.0511E0 ADRA1A, ADRA1B, ADRA1D, ADRA2A, ADRA2B MAPK cascade, adrenergic receptor signaling pathway, amine transport, calcium ion-dependent exocytosis, cardiac muscle contraction, cell proliferation, cellular catabolic process, cellular process, epidermal growth factor receptor signaling pathway, glycogen catabolic process, heart contraction, lipid catabolic process, neuron differentiation, peptidyl-tyrosine phosphorylation ENSG00000120907, ENSG00000150594, ENSG00000170214, ENSG00000171873, ENSG00000222040
Diazoxide 330 60 0.0507E0 CA2, GLUL epithelial cell proliferation, insulin secretion, intracellular pH reduction, synaptic transmission, glutamatergic ENSG00000104267, ENSG00000135821
Ethyl biscoumacetate 330 60 0.0507E0 GLUL, NQO1 epithelial cell proliferation, insulin secretion, neuron apoptotic process, synaptic transmission, glutamatergic ENSG00000135821, ENSG00000181019
L-Methionine, Picrotoxin 330 60 0.0507E0 GLUL epithelial cell proliferation, insulin secretion, synaptic transmission, glutamatergic ENSG00000135821
Metergoline 346 44 0.0498E0 HTR1A, HTR1B, HTR1F, HTR2A, HTR2B, HTR2C, HTR4, HTR6 G-protein coupled receptor signaling pathway, I-kappaB kinase/NF-kappaB cascade, MAPK cascade, amine transport, apoptotic process, autophagy, cAMP biosynthetic process, cAMP metabolic process, cell division, cell proliferation, cellular carbohydrate metabolic process, cellular process, cytokine secretion, diacylglycerol biosynthetic process, endothelial cell proliferation, inositol trisphosphate biosynthetic process, locomotion, potassium ion transport, protein phosphorylation, sequestering of calcium ion, synaptic transmission, synaptic transmission, GABAergic, synaptic transmission, glutamatergic, vasoconstriction ENSG00000102468, ENSG00000135312, ENSG00000135914, ENSG00000147246, ENSG00000158748, ENSG00000164270, ENSG00000178394, ENSG00000179097
Bleomycin 377 13 0.0487E0 LIG3 DNA recombination ENSG00000005156
Naloxone 380 10 0.0484E0 OPRM1, TLR4 B cell proliferation, ERK1 and ERK2 cascade, JNK cascade, cAMP biosynthetic process, cell development, cell proliferation, chemokine production, immune effector process, inflammatory response, innate immune response, interferon-gamma production, interleukin-10 production, interleukin-6 production, neurogenesis, nitric oxide biosynthetic process, osteoclast differentiation, protein phosphorylation, response to external stimulus, transcription from RNA polymerase II promoter ENSG00000112038, ENSG00000136869
Eritoran sodium, Eritoran tetrasodium 380 10 0.0484E0 TLR4 B cell proliferation, ERK1 and ERK2 cascade, JNK cascade, chemokine production, immune effector process, inflammatory response, innate immune response, interferon-gamma production, interleukin-10 production, interleukin-6 production, nitric oxide biosynthetic process, osteoclast differentiation, protein phosphorylation, response to external stimulus, transcription from RNA polymerase II promoter ENSG00000136869
Sertindole 354 36 0.0484E0 ADRA1A, ADRA1B, ADRA1D, DRD2, HTR2A, HTR2C, HTR6 MAPK cascade, amine transport, cardiac muscle contraction, cell proliferation, cellular carbohydrate metabolic process, cellular catabolic process, cellular process, diacylglycerol biosynthetic process, dopamine receptor signaling pathway, glycogen catabolic process, growth hormone secretion, heart contraction, inositol trisphosphate biosynthetic process, locomotion, potassium ion transport, protein phosphorylation, sequestering of calcium ion, synaptic transmission, synaptic transmission, glutamatergic, vasoconstriction ENSG00000102468, ENSG00000120907, ENSG00000147246, ENSG00000149295, ENSG00000158748, ENSG00000170214, ENSG00000171873
Acepromazine, Thioproperazine 355 35 0.048E0 ADRA1A, ADRA1B, DRD1, DRD2, HTR1A, HTR2A MAPK cascade, cAMP biosynthetic process, cardiac muscle contraction, cell migration, cell proliferation, cellular carbohydrate metabolic process, cellular catabolic process, cellular process, dopamine receptor signaling pathway, glycogen catabolic process, growth hormone secretion, heart contraction, inositol trisphosphate biosynthetic process, potassium ion transport, protein phosphorylation, response to external stimulus, sequestering of calcium ion, synaptic transmission, synaptic transmission, glutamatergic, vasoconstriction ENSG00000102468, ENSG00000120907, ENSG00000149295, ENSG00000170214, ENSG00000178394, ENSG00000184845
Flupentixol 355 35 0.048E0 ADRA1A, CHRM1, DRD1, DRD2, HTR2A MAPK cascade, cAMP biosynthetic process, cardiac muscle contraction, cell migration, cell proliferation, cellular carbohydrate metabolic process, dopamine receptor signaling pathway, growth hormone secretion, inositol trisphosphate biosynthetic process, ion transport, potassium ion transport, protein phosphorylation, response to external stimulus, sequestering of calcium ion, synaptic transmission, synaptic transmission, glutamatergic, vasoconstriction ENSG00000102468, ENSG00000120907, ENSG00000149295, ENSG00000168539, ENSG00000184845
Zuclopenthixol 355 35 0.048E0 ADRA1A, ADRA2A, DRD1, DRD2, HTR2A MAPK cascade, adrenergic receptor signaling pathway, cAMP biosynthetic process, calcium ion-dependent exocytosis, cardiac muscle contraction, cell migration, cell proliferation, cellular carbohydrate metabolic process, dopamine receptor signaling pathway, growth hormone secretion, inositol trisphosphate biosynthetic process, lipid catabolic process, potassium ion transport, protein phosphorylation, response to external stimulus, sequestering of calcium ion, synaptic transmission, synaptic transmission, glutamatergic, vasoconstriction ENSG00000102468, ENSG00000120907, ENSG00000149295, ENSG00000150594, ENSG00000184845
Thioridazine 355 35 0.048E0 ADRA1A, ADRA1B, DRD1, DRD2, HTR2A MAPK cascade, cAMP biosynthetic process, cardiac muscle contraction, cell migration, cell proliferation, cellular carbohydrate metabolic process, cellular catabolic process, dopamine receptor signaling pathway, glycogen catabolic process, growth hormone secretion, heart contraction, inositol trisphosphate biosynthetic process, potassium ion transport, protein phosphorylation, response to external stimulus, sequestering of calcium ion, synaptic transmission, synaptic transmission, glutamatergic, vasoconstriction ENSG00000102468, ENSG00000120907, ENSG00000149295, ENSG00000170214, ENSG00000184845
Sepantronium bromide 223 167 0.047E0 BIRC5 cell cycle phase transition, cell proliferation, neuron apoptotic process, transcription, DNA-dependent ENSG00000089685
Chlorprothixene 353 37 0.0468E0 CHRM1, CHRM2, DRD1, DRD2, DRD3, HTR2A, HTR2B, HTR2C G-protein coupled receptor signaling pathway, I-kappaB kinase/NF-kappaB cascade, MAPK cascade, apoptotic process, autophagy, cAMP biosynthetic process, cAMP metabolic process, cell division, cell migration, cell proliferation, cellular carbohydrate metabolic process, cytokine secretion, diacylglycerol biosynthetic process, dopamine receptor signaling pathway, endothelial cell proliferation, growth hormone secretion, inositol trisphosphate biosynthetic process, ion transport, locomotion, oligodendrocyte differentiation, potassium ion transport, protein phosphorylation, response to external stimulus, sequestering of calcium ion, synaptic transmission, synaptic transmission, glutamatergic, vasoconstriction ENSG00000102468, ENSG00000135914, ENSG00000147246, ENSG00000149295, ENSG00000151577, ENSG00000168539, ENSG00000181072, ENSG00000184845
Cipemastat 371 19 0.0461E0 ADAM8 MAPK cascade, T cell differentiation in thymus, acute inflammatory response, bone resorption, cell adhesion, cellular catabolic process, eosinophil migration, innate immune response, membrane protein ectodomain proteolysis, neuron apoptotic process, neutrophil extravasation, protein catabolic process, protein kinase B signaling cascade, protein phosphorylation, protein processing, protein secretion, response to external stimulus ENSG00000151651
Loxapine 356 34 0.0449E0 DRD1, DRD2, HTR2A, HTR2C MAPK cascade, cAMP biosynthetic process, cell migration, cell proliferation, cellular carbohydrate metabolic process, diacylglycerol biosynthetic process, dopamine receptor signaling pathway, growth hormone secretion, inositol trisphosphate biosynthetic process, locomotion, potassium ion transport, protein phosphorylation, response to external stimulus, sequestering of calcium ion, synaptic transmission, synaptic transmission, glutamatergic, vasoconstriction ENSG00000102468, ENSG00000147246, ENSG00000149295, ENSG00000184845
Pipotiazine 356 34 0.0449E0 DRD1, DRD2, HTR1A, HTR2A MAPK cascade, cAMP biosynthetic process, cell migration, cell proliferation, cellular carbohydrate metabolic process, cellular process, dopamine receptor signaling pathway, growth hormone secretion, inositol trisphosphate biosynthetic process, potassium ion transport, protein phosphorylation, response to external stimulus, sequestering of calcium ion, synaptic transmission, synaptic transmission, glutamatergic, vasoconstriction ENSG00000102468, ENSG00000149295, ENSG00000178394, ENSG00000184845
Thiothixene 356 34 0.0449E0 DRD1, DRD2, HTR2A MAPK cascade, cAMP biosynthetic process, cell migration, cell proliferation, cellular carbohydrate metabolic process, dopamine receptor signaling pathway, growth hormone secretion, inositol trisphosphate biosynthetic process, potassium ion transport, protein phosphorylation, response to external stimulus, sequestering of calcium ion, synaptic transmission, synaptic transmission, glutamatergic, vasoconstriction ENSG00000102468, ENSG00000149295, ENSG00000184845
Ribavirin 372 18 0.044E0 ENPP1 cell growth, fat cell differentiation, glucose import, glycogen biosynthetic process, insulin receptor signaling pathway, ossification, protein autophosphorylation ENSG00000197594
Aprotinin solution, Ecallantide, Gabexate 372 18 0.0438E0 KLKB1 fibrinolysis ENSG00000164344
Piribedil 376 14 0.0437E0 ADRA2A, ADRA2B, DRD2, DRD3 MAPK cascade, adrenergic receptor signaling pathway, amine transport, calcium ion-dependent exocytosis, dopamine receptor signaling pathway, epidermal growth factor receptor signaling pathway, growth hormone secretion, lipid catabolic process, neuron differentiation, oligodendrocyte differentiation, peptidyl-tyrosine phosphorylation ENSG00000149295, ENSG00000150594, ENSG00000151577, ENSG00000222040
Fenoldopam mesylate 376 14 0.0437E0 ADRA2A, ADRA2B, DRD1 MAPK cascade, adrenergic receptor signaling pathway, amine transport, cAMP biosynthetic process, calcium ion-dependent exocytosis, cell migration, epidermal growth factor receptor signaling pathway, lipid catabolic process, neuron differentiation, peptidyl-tyrosine phosphorylation, potassium ion transport, response to external stimulus, synaptic transmission, synaptic transmission, glutamatergic ENSG00000150594, ENSG00000184845, ENSG00000222040
Cabergoline 376 14 0.0437E0 ADRA2A, ADRA2B, DRD1, DRD2, DRD3, DRD4, HTR1A, HTR1B, HTR2A, HTR2B, HTR2C G-protein coupled receptor signaling pathway, I-kappaB kinase/NF-kappaB cascade, MAPK cascade, adrenergic receptor signaling pathway, amine transport, apoptotic process, autophagy, cAMP biosynthetic process, calcium ion-dependent exocytosis, cell division, cell migration, cell proliferation, cellular carbohydrate metabolic process, cellular process, cytokine secretion, diacylglycerol biosynthetic process, dopamine receptor signaling pathway, dopamine uptake involved in synaptic transmission, endothelial cell proliferation, epidermal growth factor receptor signaling pathway, growth hormone secretion, inositol trisphosphate biosynthetic process, lipid catabolic process, locomotion, neuron differentiation, oligodendrocyte differentiation, peptidyl-tyrosine phosphorylation, potassium ion transport, protein phosphorylation, protein secretion, response to external stimulus, sequestering of calcium ion, synaptic transmission, synaptic transmission, GABAergic, synaptic transmission, glutamatergic, vasoconstriction ENSG00000069696, ENSG00000102468, ENSG00000135312, ENSG00000135914, ENSG00000147246, ENSG00000149295, ENSG00000150594, ENSG00000151577, ENSG00000178394, ENSG00000184845, ENSG00000222040
Aptazapine maleate, Atipamezole, Delequamine hydrochloride, Fluparoxan hydrochloride 376 14 0.0437E0 ADRA2A, ADRA2B MAPK cascade, adrenergic receptor signaling pathway, amine transport, calcium ion-dependent exocytosis, epidermal growth factor receptor signaling pathway, lipid catabolic process, neuron differentiation, peptidyl-tyrosine phosphorylation ENSG00000150594, ENSG00000222040
Imiloxan hydrochloride 376 14 0.0437E0 ADRA2B MAPK cascade, amine transport, epidermal growth factor receptor signaling pathway, neuron differentiation, peptidyl-tyrosine phosphorylation ENSG00000222040
Rotigotine 376 14 0.0437E0 ADRA2B, DRD1, DRD2, DRD3, DRD4, HTR1A MAPK cascade, amine transport, cAMP biosynthetic process, cell migration, cell proliferation, cellular process, dopamine receptor signaling pathway, dopamine uptake involved in synaptic transmission, epidermal growth factor receptor signaling pathway, growth hormone secretion, neuron differentiation, oligodendrocyte differentiation, peptidyl-tyrosine phosphorylation, potassium ion transport, protein phosphorylation, protein secretion, response to external stimulus, synaptic transmission, synaptic transmission, glutamatergic ENSG00000069696, ENSG00000149295, ENSG00000151577, ENSG00000178394, ENSG00000184845, ENSG00000222040
Fluoxymesterone 383 7 0.0422E0 AR, PRLR MAPK cascade, apoptotic process, cell proliferation, epithelial cell proliferation, insulin-like growth factor receptor signaling pathway, intracellular estrogen receptor signaling pathway, phosphorylation, protein phosphorylation, transcription from RNA polymerase II promoter ENSG00000113494, ENSG00000169083
Quinacrine 386 4 0.0414E0 PLA2G6 arachidonic acid secretion, exocytosis, immune response, protein kinase C signaling cascade, protein phosphorylation, release of cytochrome c from mitochondria, synaptic transmission, glutamatergic, vasodilation ENSG00000184381
Pizotifen malate, Pizotyline 353 37 0.0405E0 HTR1A, HTR1B, HTR1F, HTR2A, HTR2C G-protein coupled receptor signaling pathway, MAPK cascade, cAMP biosynthetic process, cAMP metabolic process, cell proliferation, cellular carbohydrate metabolic process, cellular process, diacylglycerol biosynthetic process, inositol trisphosphate biosynthetic process, locomotion, potassium ion transport, protein phosphorylation, sequestering of calcium ion, synaptic transmission, GABAergic, synaptic transmission, glutamatergic, vasoconstriction ENSG00000102468, ENSG00000135312, ENSG00000147246, ENSG00000178394, ENSG00000179097
Arsenic trioxide 322 68 0.0394E0 AKT1, CCND1, JUN, MAPK1, MAPK3, TXNRD1 DNA replication, ERK1 and ERK2 cascade, G1/S transition of mitotic cell cycle, JNK cascade, T cell activation, Wnt receptor signaling pathway, autophagy, blood vessel endothelial cell migration, cell cycle, cell death, cell growth, cell proliferation, endothelial cell proliferation, epithelial cell differentiation, establishment of protein localization to plasma membrane, fat cell differentiation, fibroblast proliferation, glucose import, glycogen biosynthetic process, histone acetylation, innate immune response, neuron apoptotic process, nitric oxide biosynthetic process, peptidyl-serine phosphorylation, peptidyl-threonine phosphorylation, proteasomal ubiquitin-dependent protein catabolic process, protein autophosphorylation, protein phosphorylation, proteolysis, release of cytochrome c from mitochondria, smooth muscle cell proliferation, sodium ion transport, transcription from RNA polymerase II promoter, transcription, DNA-dependent, vasoconstriction, viral transcription ENSG00000100030, ENSG00000102882, ENSG00000110092, ENSG00000142208, ENSG00000177606, ENSG00000198431
Opipramol 355 35 0.0356E0 DRD2, HTR2A, HTR2B, HTR2C G-protein coupled receptor signaling pathway, I-kappaB kinase/NF-kappaB cascade, MAPK cascade, apoptotic process, autophagy, cell division, cell proliferation, cellular carbohydrate metabolic process, cytokine secretion, diacylglycerol biosynthetic process, dopamine receptor signaling pathway, endothelial cell proliferation, growth hormone secretion, inositol trisphosphate biosynthetic process, locomotion, potassium ion transport, protein phosphorylation, sequestering of calcium ion, synaptic transmission, glutamatergic, vasoconstriction ENSG00000102468, ENSG00000135914, ENSG00000147246, ENSG00000149295
Lurasidone hydrochloride 355 35 0.0356E0 DRD2, HTR1A, HTR2A, HTR2B, HTR2C G-protein coupled receptor signaling pathway, I-kappaB kinase/NF-kappaB cascade, MAPK cascade, apoptotic process, autophagy, cell division, cell proliferation, cellular carbohydrate metabolic process, cellular process, cytokine secretion, diacylglycerol biosynthetic process, dopamine receptor signaling pathway, endothelial cell proliferation, growth hormone secretion, inositol trisphosphate biosynthetic process, locomotion, potassium ion transport, protein phosphorylation, sequestering of calcium ion, synaptic transmission, glutamatergic, vasoconstriction ENSG00000102468, ENSG00000135914, ENSG00000147246, ENSG00000149295, ENSG00000178394
Promethazine 359 31 0.0336E0 CALM1, CALM2, CALM3, CHRM1, CHRM2, DRD2, HTR2A MAPK cascade, cAMP metabolic process, cell proliferation, cellular carbohydrate metabolic process, cyclic nucleotide metabolic process, dopamine receptor signaling pathway, growth hormone secretion, inositol trisphosphate biosynthetic process, ion transport, potassium ion transport, protein dephosphorylation, protein phosphorylation, sequestering of calcium ion, synaptic transmission, glutamatergic, transport, vasoconstriction ENSG00000102468, ENSG00000143933, ENSG00000149295, ENSG00000160014, ENSG00000168539, ENSG00000181072, ENSG00000198668
Molindone, Spiperone 359 31 0.0336E0 DRD2, HTR1A, HTR2A MAPK cascade, cell proliferation, cellular carbohydrate metabolic process, cellular process, dopamine receptor signaling pathway, growth hormone secretion, inositol trisphosphate biosynthetic process, potassium ion transport, protein phosphorylation, sequestering of calcium ion, synaptic transmission, glutamatergic, vasoconstriction ENSG00000102468, ENSG00000149295, ENSG00000178394
Blonanserin, Fluspirilene, Mesoridazine, Mosapramine, Paliperidone palmitate, Perospirone hydrochloride hydrate, Pipamperone, Zotepine 359 31 0.0336E0 DRD2, HTR2A MAPK cascade, cell proliferation, cellular carbohydrate metabolic process, dopamine receptor signaling pathway, growth hormone secretion, inositol trisphosphate biosynthetic process, potassium ion transport, protein phosphorylation, sequestering of calcium ion, synaptic transmission, glutamatergic, vasoconstriction ENSG00000102468, ENSG00000149295
Amisulpride 359 31 0.0336E0 DRD2, DRD3, HTR2A MAPK cascade, cell proliferation, cellular carbohydrate metabolic process, dopamine receptor signaling pathway, growth hormone secretion, inositol trisphosphate biosynthetic process, oligodendrocyte differentiation, potassium ion transport, protein phosphorylation, sequestering of calcium ion, synaptic transmission, glutamatergic, vasoconstriction ENSG00000102468, ENSG00000149295, ENSG00000151577
Navitoclax 374 16 0.033E0 BCL2A1, BCL2L1, MCL1 anoikis, apoptotic process, autophagy, cell proliferation, establishment of protein localization to plasma membrane, execution phase of apoptosis, intrinsic apoptotic signaling pathway, mitotic cell cycle phase transition, neuron apoptotic process, release of cytochrome c from mitochondria ENSG00000140379, ENSG00000143384, ENSG00000171552
Pelanserin hydrochloride 379 11 0.0329E0 ADRA1A, ADRA1B, ADRA1D, HTR2A, HTR2B, HTR2C G-protein coupled receptor signaling pathway, I-kappaB kinase/NF-kappaB cascade, MAPK cascade, apoptotic process, autophagy, cardiac muscle contraction, cell division, cell proliferation, cellular carbohydrate metabolic process, cellular catabolic process, cellular process, cytokine secretion, diacylglycerol biosynthetic process, endothelial cell proliferation, glycogen catabolic process, heart contraction, inositol trisphosphate biosynthetic process, locomotion, potassium ion transport, protein phosphorylation, sequestering of calcium ion, synaptic transmission, glutamatergic, vasoconstriction ENSG00000102468, ENSG00000120907, ENSG00000135914, ENSG00000147246, ENSG00000170214, ENSG00000171873
Cenicriviroc 360 30 0.0318E0 CCR2, CCR5 T-helper 1 type immune response, angiogenesis, behavior, cAMP biosynthetic process, cellular biosynthetic process, inflammatory response, interferon-gamma production, interleukin-2 production, macromolecule biosynthetic process, sequestering of calcium ion, type 2 immune response ENSG00000121807, ENSG00000160791
Imipramine 383 7 0.0309E0 ADRA1A, ADRA1D, CHRM1, CHRM2, HTR2A MAPK cascade, cAMP metabolic process, cardiac muscle contraction, cell proliferation, cellular carbohydrate metabolic process, cellular process, heart contraction, inositol trisphosphate biosynthetic process, ion transport, potassium ion transport, protein phosphorylation, sequestering of calcium ion, synaptic transmission, glutamatergic, vasoconstriction ENSG00000102468, ENSG00000120907, ENSG00000168539, ENSG00000171873, ENSG00000181072
Nortriptyline 383 7 0.0309E0 ADRA1A, ADRA1D, CHRM1, CHRM2, HTR1A, HTR2A MAPK cascade, cAMP metabolic process, cardiac muscle contraction, cell proliferation, cellular carbohydrate metabolic process, cellular process, heart contraction, inositol trisphosphate biosynthetic process, ion transport, potassium ion transport, protein phosphorylation, sequestering of calcium ion, synaptic transmission, glutamatergic, vasoconstriction ENSG00000102468, ENSG00000120907, ENSG00000168539, ENSG00000171873, ENSG00000178394, ENSG00000181072
Amitriptyline 383 7 0.0309E0 ADRA1A, ADRA1D, ADRA2A, CHRM1, CHRM2, HTR2A, NTRK1, NTRK2 ERK1 and ERK2 cascade, MAPK cascade, Ras protein signal transduction, adrenergic receptor signaling pathway, angiogenesis, anoikis, axonogenesis, cAMP biosynthetic process, cAMP metabolic process, calcium ion-dependent exocytosis, cardiac muscle contraction, cell proliferation, cellular carbohydrate metabolic process, cellular process, gene expression, heart contraction, inositol trisphosphate biosynthetic process, ion transport, lipid catabolic process, neuron apoptotic process, neuron projection development, phosphatidylinositol 3-kinase cascade, potassium ion transport, programmed cell death, protein phosphorylation, sequestering of calcium ion, synaptic transmission, glutamatergic, vasoconstriction ENSG00000102468, ENSG00000120907, ENSG00000148053, ENSG00000150594, ENSG00000168539, ENSG00000171873, ENSG00000181072, ENSG00000198400
Ketanserin 383 7 0.0309E0 ADRA1A, ADRA1B, ADRA1D, HTR2A MAPK cascade, cardiac muscle contraction, cell proliferation, cellular carbohydrate metabolic process, cellular catabolic process, cellular process, glycogen catabolic process, heart contraction, inositol trisphosphate biosynthetic process, potassium ion transport, protein phosphorylation, sequestering of calcium ion, synaptic transmission, glutamatergic, vasoconstriction ENSG00000102468, ENSG00000120907, ENSG00000170214, ENSG00000171873
Conivaptan, Tolvaptan 384 6 0.0278E0 AVPR1A, AVPR2 amine transport, cAMP biosynthetic process, cell growth, cell proliferation, gene expression, heart contraction, prostaglandin biosynthetic process, protein ubiquitination, secretion, vasoconstriction ENSG00000126895, ENSG00000166148
Lixivaptan, Mozavaptane hydrochloride 384 6 0.0278E0 AVPR2 cAMP biosynthetic process, cell proliferation, gene expression, protein ubiquitination, secretion ENSG00000126895
Fananserin 385 5 0.0269E0 DRD4, HTR2A MAPK cascade, amine transport, cAMP biosynthetic process, cell proliferation, cellular carbohydrate metabolic process, dopamine uptake involved in synaptic transmission, inositol trisphosphate biosynthetic process, potassium ion transport, protein phosphorylation, protein secretion, sequestering of calcium ion, synaptic transmission, glutamatergic, vasoconstriction ENSG00000069696, ENSG00000102468
Desipramine 384 6 0.0267E0 ADRA1A, CHRM1, CHRM2, HTR2A, SLC22A5 MAPK cascade, cAMP metabolic process, cardiac muscle contraction, cell proliferation, cellular carbohydrate metabolic process, inositol trisphosphate biosynthetic process, intestinal epithelial structure maintenance, ion transport, potassium ion transport, protein phosphorylation, sequestering of calcium ion, synaptic transmission, glutamatergic, vasoconstriction ENSG00000102468, ENSG00000120907, ENSG00000168539, ENSG00000181072, ENSG00000197375
Nefazodone, Trazodone 384 6 0.0267E0 ADRA1A, ADRA2A, HTR1A, HTR2A, HTR2C MAPK cascade, adrenergic receptor signaling pathway, calcium ion-dependent exocytosis, cardiac muscle contraction, cell proliferation, cellular carbohydrate metabolic process, cellular process, diacylglycerol biosynthetic process, inositol trisphosphate biosynthetic process, lipid catabolic process, locomotion, potassium ion transport, protein phosphorylation, sequestering of calcium ion, synaptic transmission, glutamatergic, vasoconstriction ENSG00000102468, ENSG00000120907, ENSG00000147246, ENSG00000150594, ENSG00000178394
Methysergide 382 8 0.0255E0 HTR1A, HTR1B, HTR2A, HTR2B, HTR2C G-protein coupled receptor signaling pathway, I-kappaB kinase/NF-kappaB cascade, MAPK cascade, apoptotic process, autophagy, cAMP biosynthetic process, cell division, cell proliferation, cellular carbohydrate metabolic process, cellular process, cytokine secretion, diacylglycerol biosynthetic process, endothelial cell proliferation, inositol trisphosphate biosynthetic process, locomotion, potassium ion transport, protein phosphorylation, sequestering of calcium ion, synaptic transmission, GABAergic, synaptic transmission, glutamatergic, vasoconstriction ENSG00000102468, ENSG00000135312, ENSG00000135914, ENSG00000147246, ENSG00000178394
Clomipramine 382 8 0.0255E0 GSTP1, HTR2A, HTR2B, HTR2C G-protein coupled receptor signaling pathway, I-kappaB kinase/NF-kappaB cascade, MAPK cascade, apoptotic process, autophagy, cell division, cell proliferation, cellular carbohydrate metabolic process, cytokine secretion, diacylglycerol biosynthetic process, endothelial cell proliferation, inositol trisphosphate biosynthetic process, leukocyte proliferation, locomotion, potassium ion transport, protein phosphorylation, sequestering of calcium ion, superoxide anion generation, synaptic transmission, glutamatergic, tumor necrosis factor-mediated signaling pathway, vasoconstriction ENSG00000084207, ENSG00000102468, ENSG00000135914, ENSG00000147246
Cinanserin hydrochloride, Dimetotiazine, Glemanserin, Metrenperone, Tropanserin hydrochloride 382 8 0.0255E0 HTR2A, HTR2B, HTR2C G-protein coupled receptor signaling pathway, I-kappaB kinase/NF-kappaB cascade, MAPK cascade, apoptotic process, autophagy, cell division, cell proliferation, cellular carbohydrate metabolic process, cytokine secretion, diacylglycerol biosynthetic process, endothelial cell proliferation, inositol trisphosphate biosynthetic process, locomotion, potassium ion transport, protein phosphorylation, sequestering of calcium ion, synaptic transmission, glutamatergic, vasoconstriction ENSG00000102468, ENSG00000135914, ENSG00000147246
Adatanserin hydrochloride, Flibanserin 382 8 0.0255E0 HTR1A, HTR2A, HTR2B, HTR2C G-protein coupled receptor signaling pathway, I-kappaB kinase/NF-kappaB cascade, MAPK cascade, apoptotic process, autophagy, cell division, cell proliferation, cellular carbohydrate metabolic process, cellular process, cytokine secretion, diacylglycerol biosynthetic process, endothelial cell proliferation, inositol trisphosphate biosynthetic process, locomotion, potassium ion transport, protein phosphorylation, sequestering of calcium ion, synaptic transmission, glutamatergic, vasoconstriction ENSG00000102468, ENSG00000135914, ENSG00000147246, ENSG00000178394
Tegaserod 382 8 0.0255E0 HTR2A, HTR2B, HTR2C, HTR4 G-protein coupled receptor signaling pathway, I-kappaB kinase/NF-kappaB cascade, MAPK cascade, apoptotic process, autophagy, cAMP metabolic process, cell division, cell proliferation, cellular carbohydrate metabolic process, cytokine secretion, diacylglycerol biosynthetic process, endothelial cell proliferation, inositol trisphosphate biosynthetic process, locomotion, potassium ion transport, protein phosphorylation, sequestering of calcium ion, synaptic transmission, glutamatergic, vasoconstriction ENSG00000102468, ENSG00000135914, ENSG00000147246, ENSG00000164270
Minaprine 382 8 0.0255E0 ACHE, CHRM1, DRD1, DRD2, HTR2A, HTR2B, HTR2C G-protein coupled receptor signaling pathway, I-kappaB kinase/NF-kappaB cascade, MAPK cascade, apoptotic process, autophagy, cAMP biosynthetic process, cell division, cell migration, cell proliferation, cellular carbohydrate metabolic process, cytokine secretion, diacylglycerol biosynthetic process, dopamine receptor signaling pathway, endothelial cell proliferation, growth hormone secretion, inositol trisphosphate biosynthetic process, ion transport, locomotion, potassium ion transport, protein phosphorylation, protein secretion, response to external stimulus, sequestering of calcium ion, synaptic transmission, synaptic transmission, cholinergic, synaptic transmission, glutamatergic, vasoconstriction ENSG00000087085, ENSG00000102468, ENSG00000135914, ENSG00000147246, ENSG00000149295, ENSG00000168539, ENSG00000184845
Oxiperomide 359 31 0.0247E0 DRD1, DRD2, DRD3, DRD4 MAPK cascade, amine transport, cAMP biosynthetic process, cell migration, dopamine receptor signaling pathway, dopamine uptake involved in synaptic transmission, growth hormone secretion, oligodendrocyte differentiation, potassium ion transport, protein phosphorylation, protein secretion, response to external stimulus, synaptic transmission, synaptic transmission, glutamatergic ENSG00000069696, ENSG00000149295, ENSG00000151577, ENSG00000184845
Thiethylperazine 359 31 0.0247E0 DRD1, DRD2, DRD4 MAPK cascade, amine transport, cAMP biosynthetic process, cell migration, dopamine receptor signaling pathway, dopamine uptake involved in synaptic transmission, growth hormone secretion, potassium ion transport, protein phosphorylation, protein secretion, response to external stimulus, synaptic transmission, synaptic transmission, glutamatergic ENSG00000069696, ENSG00000149295, ENSG00000184845
Amoxapine 359 31 0.0245E0 ADRA1A, ADRA2A, CHRM1, DRD1, DRD2 adrenergic receptor signaling pathway, cAMP biosynthetic process, calcium ion-dependent exocytosis, cardiac muscle contraction, cell migration, dopamine receptor signaling pathway, growth hormone secretion, ion transport, lipid catabolic process, potassium ion transport, response to external stimulus, synaptic transmission, synaptic transmission, glutamatergic ENSG00000120907, ENSG00000149295, ENSG00000150594, ENSG00000168539, ENSG00000184845
Bosentan, Macitentan, Sitaxentan 370 20 0.0242E0 EDNRA, EDNRB kidney development, neuron maturation, odontogenesis, penile erection, release of sequestered calcium ion into cytosol ENSG00000136160, ENSG00000151617
Cinitapride 386 4 0.0235E0 HTR1A, HTR2A, HTR4 MAPK cascade, cAMP metabolic process, cell proliferation, cellular carbohydrate metabolic process, cellular process, inositol trisphosphate biosynthetic process, potassium ion transport, protein phosphorylation, sequestering of calcium ion, synaptic transmission, glutamatergic, vasoconstriction ENSG00000102468, ENSG00000164270, ENSG00000178394
Amesergide, Ritanserin 386 4 0.0235E0 HTR2A, HTR2C MAPK cascade, cell proliferation, cellular carbohydrate metabolic process, diacylglycerol biosynthetic process, inositol trisphosphate biosynthetic process, locomotion, potassium ion transport, protein phosphorylation, sequestering of calcium ion, synaptic transmission, glutamatergic, vasoconstriction ENSG00000102468, ENSG00000147246
Cyproheptadine hydrochloride 386 4 0.0235E0 CHRM1, CHRM2, HTR2A, HTR2C MAPK cascade, cAMP metabolic process, cell proliferation, cellular carbohydrate metabolic process, diacylglycerol biosynthetic process, inositol trisphosphate biosynthetic process, ion transport, locomotion, potassium ion transport, protein phosphorylation, sequestering of calcium ion, synaptic transmission, glutamatergic, vasoconstriction ENSG00000102468, ENSG00000147246, ENSG00000168539, ENSG00000181072
Epinastine 386 4 0.0235E0 HRH2, HTR2A MAPK cascade, cell proliferation, cellular carbohydrate metabolic process, inositol trisphosphate biosynthetic process, potassium ion transport, protein phosphorylation, sequestering of calcium ion, synaptic transmission, glutamatergic, vasoconstriction ENSG00000102468, ENSG00000113749
Altanserin tartrate, Aripiprazole cavoxil, Aripiprazole lauroxil, Cyclobenzaprine, Eplivanserin, Lubazodone hydrochloride, Nafronyl oxalate, Naftidrofuryl, Pruvanserin, Sarpogrelate, Temanogrel 386 4 0.0235E0 HTR2A MAPK cascade, cell proliferation, cellular carbohydrate metabolic process, inositol trisphosphate biosynthetic process, potassium ion transport, protein phosphorylation, sequestering of calcium ion, synaptic transmission, glutamatergic, vasoconstriction ENSG00000102468
Midostaurin 386 4 0.0234E0 FLT3, KDR, KIT, PDGFRB B cell differentiation, ERK1 and ERK2 cascade, MAPK cascade, angiogenesis, behavior, calcium ion import, cell differentiation, cell proliferation, chemotaxis, endothelial cell migration, endothelial cell proliferation, focal adhesion assembly, gene expression, lipid metabolic process, mesenchymal cell proliferation, phosphatidylinositol 3-kinase cascade, positive chemotaxis, programmed cell death, protein phosphorylation, tyrosine phosphorylation of Stat1 protein, tyrosine phosphorylation of Stat3 protein, tyrosine phosphorylation of Stat5 protein ENSG00000113721, ENSG00000122025, ENSG00000128052, ENSG00000157404
Triflupromazine 357 33 0.0233E0 CHRM1, CHRM2, DRD1, DRD2, HTR2B G-protein coupled receptor signaling pathway, I-kappaB kinase/NF-kappaB cascade, MAPK cascade, apoptotic process, autophagy, cAMP biosynthetic process, cAMP metabolic process, cell division, cell migration, cellular carbohydrate metabolic process, cytokine secretion, dopamine receptor signaling pathway, endothelial cell proliferation, growth hormone secretion, inositol trisphosphate biosynthetic process, ion transport, potassium ion transport, protein phosphorylation, response to external stimulus, sequestering of calcium ion, synaptic transmission, synaptic transmission, glutamatergic ENSG00000135914, ENSG00000149295, ENSG00000168539, ENSG00000181072, ENSG00000184845
Haloperidol 360 30 0.0214E0 DRD1, DRD2, DRD3 cAMP biosynthetic process, cell migration, dopamine receptor signaling pathway, growth hormone secretion, oligodendrocyte differentiation, potassium ion transport, response to external stimulus, synaptic transmission, synaptic transmission, glutamatergic ENSG00000149295, ENSG00000151577, ENSG00000184845
Acetophenazine, Butaclamol hydrochloride, Carphenazine, Clebopride, Clebopride malate, Clopenthixol, Flupentixol decanoate, Thiothixene hydrochloride, Tiotixene, Zuclopenthixol acetate, Zuclopenthixol decanoate 360 30 0.0214E0 DRD1, DRD2 cAMP biosynthetic process, cell migration, dopamine receptor signaling pathway, growth hormone secretion, potassium ion transport, response to external stimulus, synaptic transmission, synaptic transmission, glutamatergic ENSG00000149295, ENSG00000184845
Fluphenazine, Perphenazine 360 30 0.0214E0 CALM1, CALM2, CALM3, DRD1, DRD2 cAMP biosynthetic process, cell migration, cyclic nucleotide metabolic process, dopamine receptor signaling pathway, growth hormone secretion, potassium ion transport, protein dephosphorylation, response to external stimulus, synaptic transmission, synaptic transmission, glutamatergic, transport ENSG00000143933, ENSG00000149295, ENSG00000160014, ENSG00000184845, ENSG00000198668
Propericiazine 360 30 0.0214E0 ADRA1B, ADRA2A, DRD1, DRD2 MAPK cascade, adrenergic receptor signaling pathway, cAMP biosynthetic process, calcium ion-dependent exocytosis, cell migration, cellular catabolic process, dopamine receptor signaling pathway, glycogen catabolic process, growth hormone secretion, heart contraction, lipid catabolic process, potassium ion transport, response to external stimulus, synaptic transmission, synaptic transmission, glutamatergic ENSG00000149295, ENSG00000150594, ENSG00000170214, ENSG00000184845
Lipoic Acid 383 7 0.021E0 POR apoptotic process, cellular biosynthetic process, cholesterol biosynthetic process, chondrocyte differentiation, hormone biosynthetic process, smoothened signaling pathway ENSG00000127948
Cobimetinib, Purvalanol 361 29 0.021E0 MAPK1, MAPK3 ERK1 and ERK2 cascade, histone acetylation, innate immune response, peptidyl-threonine phosphorylation, transcription from RNA polymerase II promoter ENSG00000100030, ENSG00000102882
Amrinone 365 25 0.0198E0 PDE3A, PDE3B, TNF ERK1 and ERK2 cascade, JNK cascade, L-glutamate transport, amine transport, angiogenesis, apoptotic process, cell adhesion mediated by integrin, cell proliferation, cellular catabolic process, cytokine secretion, fat cell differentiation, fever generation, glucose import, growth of symbiont in host, hair follicle development, heterotypic cell-cell adhesion, interferon-gamma production, interleukin-6 production, lipid storage, membrane protein ectodomain proteolysis, mitosis, necroptosis, neuron apoptotic process, nitric oxide biosynthetic process, osteoblast differentiation, osteoclast differentiation, peptidyl-serine phosphorylation, podosome assembly, protein catabolic process, protein kinase B signaling cascade, protein localization to cell surface, response to external stimulus, smooth muscle cell proliferation, synaptic transmission, transcription from RNA polymerase II promoter, translational initiation, viral genome replication ENSG00000152270, ENSG00000172572, ENSG00000232810
Semaxanib 387 3 0.0189E0 FLT3, KDR, KIT B cell differentiation, ERK1 and ERK2 cascade, MAPK cascade, angiogenesis, behavior, cell differentiation, cell proliferation, endothelial cell migration, endothelial cell proliferation, focal adhesion assembly, gene expression, lipid metabolic process, mesenchymal cell proliferation, phosphatidylinositol 3-kinase cascade, positive chemotaxis, programmed cell death, protein phosphorylation, tyrosine phosphorylation of Stat1 protein, tyrosine phosphorylation of Stat3 protein, tyrosine phosphorylation of Stat5 protein ENSG00000122025, ENSG00000128052, ENSG00000157404
Acamprosate calcium 388 2 0.0179E0 GRIN2A, GRIN2C, GRM1, GRM5 G-protein coupled receptor signaling pathway, MAPK cascade, apoptotic process, cell development, neurogenesis, protein catabolic process, protein phosphorylation ENSG00000152822, ENSG00000161509, ENSG00000168959, ENSG00000183454
Fenobam, Rufinamide 388 2 0.0179E0 GRM5 G-protein coupled receptor signaling pathway, cell development, neurogenesis, protein phosphorylation ENSG00000168959
Pimozide 360 30 0.0175E0 ADRA1A, ADRA1B, ADRA1D, CALM1, CALM2, CALM3, DRD2, DRD3 MAPK cascade, cardiac muscle contraction, cell proliferation, cellular catabolic process, cellular process, cyclic nucleotide metabolic process, dopamine receptor signaling pathway, glycogen catabolic process, growth hormone secretion, heart contraction, oligodendrocyte differentiation, protein dephosphorylation, transport ENSG00000120907, ENSG00000143933, ENSG00000149295, ENSG00000151577, ENSG00000160014, ENSG00000170214, ENSG00000171873, ENSG00000198668
Nilotinib 388 2 0.0167E0 ABL1, KIT, PDGFRA, PDGFRB MAPK cascade, apoptotic process, calcium ion import, cell differentiation, cell proliferation, chemotaxis, gene expression, immune response, lipid metabolic process, muscle cell differentiation, peptidyl-tyrosine phosphorylation, phosphatidylinositol 3-kinase cascade, platelet activation, programmed cell death, protein phosphorylation, tyrosine phosphorylation of Stat1 protein, tyrosine phosphorylation of Stat3 protein, tyrosine phosphorylation of Stat5 protein ENSG00000097007, ENSG00000113721, ENSG00000134853, ENSG00000157404
Tandutinib 388 2 0.0167E0 FLT3, KIT, PDGFRB B cell differentiation, MAPK cascade, calcium ion import, cell differentiation, cell proliferation, chemotaxis, gene expression, lipid metabolic process, phosphatidylinositol 3-kinase cascade, programmed cell death, tyrosine phosphorylation of Stat1 protein, tyrosine phosphorylation of Stat3 protein, tyrosine phosphorylation of Stat5 protein ENSG00000113721, ENSG00000122025, ENSG00000157404
Icosapent 384 6 0.0167E0 ACSL3, PPARD, PPARG, SLC8A1 acute inflammatory response, apoptotic process, cell development, cell growth, cell proliferation, epithelial cell proliferation, fat cell differentiation, fatty acid oxidation, fibroblast migration, interferon-gamma-mediated signaling pathway, macrophage derived foam cell differentiation, phosphatidylinositol 3-kinase cascade, receptor biosynthetic process, response to external stimulus, secretion, sequestering of triglyceride, smooth muscle cell proliferation, transcription from RNA polymerase II promoter, transcription, DNA-dependent ENSG00000112033, ENSG00000123983, ENSG00000132170, ENSG00000183023
Thalidomide 376 14 0.0151E0 CRBN, NFKB1, TNF ERK1 and ERK2 cascade, JNK cascade, L-glutamate transport, amine transport, apoptotic process, carbohydrate metabolic process, cell proliferation, cellular catabolic process, cholesterol transport, cytokine secretion, fat cell differentiation, fever generation, glucose import, growth of symbiont in host, hair follicle development, heterotypic cell-cell adhesion, hyaluronan biosynthetic process, interferon-gamma production, interleukin-6 production, ion transmembrane transport, lipid storage, membrane protein ectodomain proteolysis, mitosis, necroptosis, neuron apoptotic process, nitric oxide biosynthetic process, osteoblast differentiation, osteoclast differentiation, peptidyl-serine phosphorylation, podosome assembly, protein catabolic process, protein kinase B signaling cascade, protein localization to cell surface, response to external stimulus, smooth muscle cell proliferation, synaptic transmission, transcription from RNA polymerase II promoter, translational initiation, viral genome replication ENSG00000109320, ENSG00000113851, ENSG00000232810
Pomalidomide 376 14 0.0151E0 CRBN, TNF ERK1 and ERK2 cascade, JNK cascade, L-glutamate transport, amine transport, apoptotic process, cell proliferation, cellular catabolic process, cytokine secretion, fat cell differentiation, fever generation, glucose import, growth of symbiont in host, hair follicle development, heterotypic cell-cell adhesion, interferon-gamma production, interleukin-6 production, ion transmembrane transport, lipid storage, membrane protein ectodomain proteolysis, mitosis, necroptosis, neuron apoptotic process, nitric oxide biosynthetic process, osteoblast differentiation, osteoclast differentiation, peptidyl-serine phosphorylation, podosome assembly, protein catabolic process, protein kinase B signaling cascade, protein localization to cell surface, response to external stimulus, smooth muscle cell proliferation, synaptic transmission, transcription from RNA polymerase II promoter, translational initiation, viral genome replication ENSG00000113851, ENSG00000232810
Certolizumab pegol, Infliximab, Lenalidomide hydrate 378 12 0.0137E0 TNF ERK1 and ERK2 cascade, JNK cascade, L-glutamate transport, amine transport, apoptotic process, cell proliferation, cellular catabolic process, cytokine secretion, fat cell differentiation, fever generation, glucose import, growth of symbiont in host, hair follicle development, heterotypic cell-cell adhesion, interferon-gamma production, interleukin-6 production, lipid storage, membrane protein ectodomain proteolysis, mitosis, necroptosis, neuron apoptotic process, nitric oxide biosynthetic process, osteoblast differentiation, osteoclast differentiation, peptidyl-serine phosphorylation, podosome assembly, protein catabolic process, protein kinase B signaling cascade, protein localization to cell surface, response to external stimulus, smooth muscle cell proliferation, synaptic transmission, transcription from RNA polymerase II promoter, translational initiation, viral genome replication ENSG00000232810
Nemonapride, Remoxipride 362 28 0.0134E0 DRD2, DRD3, DRD4 MAPK cascade, amine transport, cAMP biosynthetic process, dopamine receptor signaling pathway, dopamine uptake involved in synaptic transmission, growth hormone secretion, oligodendrocyte differentiation, protein phosphorylation, protein secretion ENSG00000069696, ENSG00000149295, ENSG00000151577
Lisuride 383 7 0.0133E0 DRD1, DRD2, DRD3, DRD4, HTR1A, HTR1B, HTR2A, HTR2B, HTR2C G-protein coupled receptor signaling pathway, I-kappaB kinase/NF-kappaB cascade, MAPK cascade, amine transport, apoptotic process, autophagy, cAMP biosynthetic process, cell division, cell migration, cell proliferation, cellular carbohydrate metabolic process, cellular process, cytokine secretion, diacylglycerol biosynthetic process, dopamine receptor signaling pathway, dopamine uptake involved in synaptic transmission, endothelial cell proliferation, growth hormone secretion, inositol trisphosphate biosynthetic process, locomotion, oligodendrocyte differentiation, potassium ion transport, protein phosphorylation, protein secretion, response to external stimulus, sequestering of calcium ion, synaptic transmission, synaptic transmission, GABAergic, synaptic transmission, glutamatergic, vasoconstriction ENSG00000069696, ENSG00000102468, ENSG00000135312, ENSG00000135914, ENSG00000147246, ENSG00000149295, ENSG00000151577, ENSG00000178394, ENSG00000184845
Droperidol 362 28 0.0132E0 ADRA1A, DRD2 cardiac muscle contraction, dopamine receptor signaling pathway, growth hormone secretion ENSG00000120907, ENSG00000149295
Trifluoperazine 362 28 0.0132E0 ADRA1A, CALM1, CALM2, CALM3, CALY, DRD2 cardiac muscle contraction, cellular component organization, cyclic nucleotide metabolic process, dopamine receptor signaling pathway, endocytosis, growth hormone secretion, protein dephosphorylation, transport ENSG00000120907, ENSG00000130643, ENSG00000143933, ENSG00000149295, ENSG00000160014, ENSG00000198668
Amuvatinib 389 1 0.0122E0 AXL, KIT MAPK cascade, cell differentiation, cell proliferation, gene expression, lipid metabolic process, lymphocyte activation, natural killer cell differentiation, phosphatidylinositol 3-kinase cascade, programmed cell death, tyrosine phosphorylation of Stat1 protein, tyrosine phosphorylation of Stat3 protein, tyrosine phosphorylation of Stat5 protein ENSG00000157404, ENSG00000167601
Masitinib 389 1 0.0122E0 KIT MAPK cascade, cell differentiation, cell proliferation, gene expression, lipid metabolic process, phosphatidylinositol 3-kinase cascade, programmed cell death, tyrosine phosphorylation of Stat1 protein, tyrosine phosphorylation of Stat3 protein, tyrosine phosphorylation of Stat5 protein ENSG00000157404
Afatinib, Canertinib dihydrochloride, Dacomitinib, Varlitinib 385 5 0.012E0 ERBB2, ERBB4 ERK1 and ERK2 cascade, MAPK cascade, apoptotic process, cardiac muscle cell proliferation, cell adhesion, cell growth, cell proliferation, epithelial cell proliferation, lipid metabolic process, protein phosphorylation, transcription from RNA polymerase I promoter, transcription, DNA-dependent, translation, tyrosine phosphorylation of Stat5 protein ENSG00000141736, ENSG00000178568
Lapatinib 385 5 0.012E0 ERBB2, TAP1 MAPK cascade, T cell mediated cytotoxicity, cell adhesion, cell growth, epithelial cell proliferation, protein phosphorylation, transcription from RNA polymerase I promoter, translation ENSG00000141736, ENSG00000168394
Mubritinib, Neratinib 385 5 0.012E0 ERBB2 MAPK cascade, cell adhesion, cell growth, epithelial cell proliferation, protein phosphorylation, transcription from RNA polymerase I promoter, translation ENSG00000141736
Ecopipam hydrochloride, Methylergometrine 386 4 0.0113E0 DRD1 cAMP biosynthetic process, cell migration, potassium ion transport, response to external stimulus, synaptic transmission, synaptic transmission, glutamatergic ENSG00000184845
Avasimibe, Eldacimibe, Ezetimibe, Hesperetin 384 6 0.0106E0 SOAT1 glycoprotein biosynthetic process ENSG00000057252
Tetrabenazine 363 27 0.0101E0 DRD2, SLC18A2 dopamine receptor signaling pathway, growth hormone secretion, neurotransmitter transport ENSG00000149295, ENSG00000165646
Cariprazine, Domperidone, Levosulpiride, Sulpiride 363 27 0.0101E0 DRD2, DRD3 dopamine receptor signaling pathway, growth hormone secretion, oligodendrocyte differentiation ENSG00000149295, ENSG00000151577
Alizapride, Bromopride, Bromperidol, Bromperidol decanoate, Clocapramine, Dihydroergotamine tartrate, Haloperidol lactate, Mazapertine succinate, Methoxypromazine maleate, Metopimazine, Moperone, Perphenazine decanoate, Perphenazine enantate, Piquindone hydrochloride, Prochlorperazine, Raclopride C11, Sultopride, Tiapride, Timiperone, Tiospirone hydrochloride, Trifluperidol, Trifluperidol hydrochloride 363 27 0.0101E0 DRD2 dopamine receptor signaling pathway, growth hormone secretion ENSG00000149295
Bifeprunox, Buspirone 363 27 0.0101E0 DRD2, HTR1A cell proliferation, cellular process, dopamine receptor signaling pathway, growth hormone secretion ENSG00000149295, ENSG00000178394
Fiboflapon, Fiboflapon sodium 388 2 0.01E0 ALOX5AP acute inflammatory response, response to external stimulus ENSG00000132965
Tacrolimus 388 2 0.0099E0 CHP1, CHP2, FKBP1A, PPP3CB I-kappaB kinase/NF-kappaB cascade, T cell mediated cytotoxicity, calcineurin-NFAT signaling cascade, cell proliferation, protein autophosphorylation, protein import into nucleus, protein ubiquitination, transcription from RNA polymerase II promoter, transcription, DNA-dependent ENSG00000088832, ENSG00000107758, ENSG00000166869, ENSG00000187446
Ciclosporin, Voclosporin 388 2 0.0099E0 CHP1, CHP2, PPP3CB T cell mediated cytotoxicity, calcineurin-NFAT signaling cascade, cell proliferation, protein autophosphorylation, protein import into nucleus, protein ubiquitination, transcription from RNA polymerase II promoter, transcription, DNA-dependent ENSG00000107758, ENSG00000166869, ENSG00000187446
Pimecrolimus 388 2 0.0099E0 CHP1, CHP2, FKBP1A, MTOR, PPP3CB I-kappaB kinase/NF-kappaB cascade, T cell activation, T cell mediated cytotoxicity, actin filament polymerization, calcineurin-NFAT signaling cascade, cell proliferation, endothelial cell proliferation, macroautophagy, myotube differentiation, peptidyl-tyrosine phosphorylation, protein autophosphorylation, protein import into nucleus, protein kinase B signaling cascade, protein ubiquitination, stress fiber assembly, transcription from RNA polymerase II promoter, transcription, DNA-dependent, translation ENSG00000088832, ENSG00000107758, ENSG00000166869, ENSG00000187446, ENSG00000198793
Velneperit 384 6 0.0095E0 NPY5R acute inflammatory response, amine transport, cellular process, response to external stimulus, smooth muscle cell proliferation, synaptic transmission, GABAergic ENSG00000164129
Enoxaparin sodium, Fondaparinux sodium 389 1 0.0084E0 F10, SERPINC1 cell migration, inflammatory response, protein kinase B signaling cascade, response to external stimulus ENSG00000117601, ENSG00000126218
Apixaban, Betrixaban, Darexaban maleate, Edoxaban, Eribaxaban, Fidexaban, Letaxaban, Razaxaban hydrochloride, Rivaroxaban 389 1 0.0084E0 F10 cell migration, protein kinase B signaling cascade ENSG00000126218
Heparin 389 1 0.0084E0 F10, SELP, SERPINC1 cell migration, inflammatory response, leukocyte migration, phosphatidylinositol 3-kinase cascade, protein kinase B signaling cascade, response to external stimulus ENSG00000117601, ENSG00000126218, ENSG00000174175
Ancriviroc, Aplaviroc hydrochloride, Maraviroc, Vicriviroc maleate 364 26 0.0083E0 CCR5 cAMP biosynthetic process, sequestering of calcium ion ENSG00000160791
Enzastaurin hydrochloride 388 2 0.0083E0 PRKCB B cell receptor signaling pathway, I-kappaB kinase/NF-kappaB cascade, angiogenesis, immune response, insulin receptor signaling pathway, vascular endothelial growth factor receptor signaling pathway ENSG00000166501
Latrepirdine 385 5 0.0074E0 ACHE, GRIN2A, GRIN2C, HTR6 amine transport, apoptotic process, protein catabolic process, protein secretion, synaptic transmission, synaptic transmission, cholinergic ENSG00000087085, ENSG00000158748, ENSG00000161509, ENSG00000183454
Cerlapirdine 385 5 0.0074E0 HTR6 amine transport, synaptic transmission ENSG00000158748
Nicardipine 386 4 0.0074E0 ADRA1A, ADRA1B, ADRA1D, CACNA1D, CACNB2, CHRM1, CHRM2 MAPK cascade, cAMP metabolic process, calcium ion transport, cardiac muscle contraction, cell proliferation, cellular catabolic process, cellular process, glycogen catabolic process, heart contraction, ion transport ENSG00000120907, ENSG00000157388, ENSG00000165995, ENSG00000168539, ENSG00000170214, ENSG00000171873, ENSG00000181072
Carvedilol 386 4 0.0074E0 ADRA1A, ADRA1B, ADRA1D, ADRB1, VCAM1 MAPK cascade, T cell proliferation, cAMP biosynthetic process, cardiac muscle contraction, cell growth involved in cardiac muscle cell development, cell proliferation, cellular catabolic process, cellular process, glycogen catabolic process, heart contraction, multicellular organism growth, multicellular organismal metabolic process, muscle organ development, saliva secretion, smooth muscle contraction ENSG00000043591, ENSG00000120907, ENSG00000162692, ENSG00000170214, ENSG00000171873
Amosulalol, Arotinolol, Bunitrolol hydrochloride, Labetalol hydrochloride, Levobunolol, Medroxalol, Nipradilol 386 4 0.0074E0 ADRA1A, ADRA1B, ADRA1D, ADRB1 MAPK cascade, cAMP biosynthetic process, cardiac muscle contraction, cell growth involved in cardiac muscle cell development, cell proliferation, cellular catabolic process, cellular process, glycogen catabolic process, heart contraction, multicellular organism growth, multicellular organismal metabolic process, muscle organ development, saliva secretion, smooth muscle contraction ENSG00000043591, ENSG00000120907, ENSG00000170214, ENSG00000171873
Bunazosin, Doxazosin, Ifenprodil, Ifenprodil tartrate, Indoramin, Moxisylyte, Naftopidil, Prazosin, Silodosin, Tamsulosin, Terazosin, Trimazosin, Urapidil 386 4 0.0074E0 ADRA1A, ADRA1B, ADRA1D MAPK cascade, cardiac muscle contraction, cell proliferation, cellular catabolic process, cellular process, glycogen catabolic process, heart contraction ENSG00000120907, ENSG00000170214, ENSG00000171873
Suramin hexasodium 386 4 0.007E0 CFTR, P2RX2, P2RX7, RYR2 calcium ion transport into cytosol, calcium-mediated signaling, cardiac muscle contraction, cytolysis, cytoskeleton organization, gamma-aminobutyric acid secretion, glutamate secretion, mitochondrial depolarization, transport, vasodilation ENSG00000001626, ENSG00000089041, ENSG00000187848, ENSG00000198626
Talnetant hydrochloride 383 7 0.0069E0 TACR3 heart contraction ENSG00000169836
L-Tryptophan 350 40 0.0067E0 WARS cell proliferation, cellular process ENSG00000140105
Vandetanib 388 2 0.0066E0 KDR, PTK6, VEGFA ERK1 and ERK2 cascade, angiogenesis, behavior, endothelial cell chemotaxis, endothelial cell migration, endothelial cell proliferation, focal adhesion assembly, growth, mast cell chemotaxis, mesenchymal cell proliferation, peptidyl-tyrosine autophosphorylation, phosphatidylinositol 3-kinase cascade, positive chemotaxis, protein phosphorylation ENSG00000101213, ENSG00000112715, ENSG00000128052
Pegdinetanib 388 2 0.0066E0 KDR ERK1 and ERK2 cascade, angiogenesis, behavior, endothelial cell migration, endothelial cell proliferation, focal adhesion assembly, mesenchymal cell proliferation, phosphatidylinositol 3-kinase cascade, positive chemotaxis, protein phosphorylation ENSG00000128052
Fomepizole 386 4 0.0065E0 CAT apoptotic process, cell division, phosphatidylinositol 3-kinase cascade ENSG00000121691
Fasudil, Fasudil hydrochloride hydrate 387 3 0.0064E0 ROCK1, ROCK2 angiogenesis, neuron apoptotic process ENSG00000067900, ENSG00000134318
Beradilol monoethyl maleate 377 13 0.0061E0 ADRB1, PDE3A, PDE3B angiogenesis, apoptotic process, cAMP biosynthetic process, cell adhesion mediated by integrin, cell growth involved in cardiac muscle cell development, heart contraction, multicellular organism growth, multicellular organismal metabolic process, muscle organ development, saliva secretion, smooth muscle contraction ENSG00000043591, ENSG00000152270, ENSG00000172572
Proxyphylline 377 13 0.0061E0 ADORA1, ADORA2A, PDE2A, PDE3A, PDE3B alpha-beta T cell activation, angiogenesis, apoptotic process, cAMP biosynthetic process, cardiac muscle contraction, cell adhesion mediated by integrin, glutamate secretion, hormone secretion, inflammatory response, lipid catabolic process, locomotion, protein import into nucleus, translocation, response to external stimulus, transcription from RNA polymerase II promoter ENSG00000128271, ENSG00000152270, ENSG00000163485, ENSG00000172572, ENSG00000186642
Ibudilast 377 13 0.0061E0 PDE3A, PDE3B, PTGIR angiogenesis, apoptotic process, cAMP biosynthetic process, cell adhesion mediated by integrin, platelet-derived growth factor receptor signaling pathway, smooth muscle cell proliferation ENSG00000152270, ENSG00000160013, ENSG00000172572
Moxaverine, Papaverine, Papaverine sulfate, Propentofylline, Tibenelast sodium, Trapidil 377 13 0.0061E0 PDE2A, PDE3A, PDE3B angiogenesis, apoptotic process, cAMP biosynthetic process, cell adhesion mediated by integrin, inflammatory response, protein import into nucleus, translocation, response to external stimulus, transcription from RNA polymerase II promoter ENSG00000152270, ENSG00000172572, ENSG00000186642
Anagrelide, Cilostazol, Enoximone, Imazodan hydrochloride, Inamrinone lactate, Indolidan, Isomazole hydrochloride, Levosimendan, Lixazinone sulfate, Milrinone, Olprinone, Pimobendan, Toborinone, Vesnarinone 377 13 0.0061E0 PDE3A, PDE3B angiogenesis, apoptotic process, cell adhesion mediated by integrin ENSG00000152270, ENSG00000172572
Flavoxate 377 13 0.0061E0 CHRM1, CHRM2, PDE2A, PDE3A, PDE3B angiogenesis, apoptotic process, cAMP biosynthetic process, cAMP metabolic process, cell adhesion mediated by integrin, inflammatory response, ion transport, protein import into nucleus, translocation, response to external stimulus, transcription from RNA polymerase II promoter ENSG00000152270, ENSG00000168539, ENSG00000172572, ENSG00000181072, ENSG00000186642
Theophylline 377 13 0.0061E0 ADA, ADORA1, ADORA2A, ADORA2B, HDAC2, PDE2A, PDE3A, PDE3B, PDE5A B cell proliferation, MAPK cascade, T cell differentiation in thymus, T cell proliferation, T cell receptor signaling pathway, adenosine receptor signaling pathway, alpha-beta T cell activation, angiogenesis, apoptotic process, cAMP biosynthetic process, cGMP biosynthetic process, calcium-mediated signaling, canonical Wnt receptor signaling pathway, cardiac muscle cell proliferation, cardiac muscle contraction, cardiac muscle hypertrophy, cell adhesion mediated by integrin, cell cycle, cell development, cell proliferation, cellular protein metabolic process, collagen biosynthetic process, glutamate secretion, heart contraction, hormone secretion, inflammatory response, leukocyte migration, lipid catabolic process, locomotion, neuron projection development, protein import into nucleus, translocation, protein phosphorylation, proteolysis, receptor biosynthetic process, response to external stimulus, smooth muscle contraction, transcription from RNA polymerase II promoter ENSG00000128271, ENSG00000138735, ENSG00000152270, ENSG00000163485, ENSG00000170425, ENSG00000172572, ENSG00000186642, ENSG00000196591, ENSG00000196839
Aminophylline, Choline theophylline 377 13 0.0061E0 ADORA1, ADORA2A, HDAC2, PDE2A, PDE3A, PDE3B alpha-beta T cell activation, angiogenesis, apoptotic process, cAMP biosynthetic process, canonical Wnt receptor signaling pathway, cardiac muscle cell proliferation, cardiac muscle contraction, cell adhesion mediated by integrin, cell cycle, cell development, cell proliferation, cellular protein metabolic process, collagen biosynthetic process, glutamate secretion, hormone secretion, inflammatory response, lipid catabolic process, locomotion, neuron projection development, protein import into nucleus, translocation, proteolysis, receptor biosynthetic process, response to external stimulus, transcription from RNA polymerase II promoter ENSG00000128271, ENSG00000152270, ENSG00000163485, ENSG00000172572, ENSG00000186642, ENSG00000196591
Testosterone propionate 386 4 0.0061E0 AR, COMT MAPK cascade, apoptotic process, cell proliferation, cellular amine metabolic process, dopamine metabolic process, epithelial cell proliferation, insulin-like growth factor receptor signaling pathway, intracellular estrogen receptor signaling pathway, phosphorylation, smooth muscle cell proliferation, transcription from RNA polymerase II promoter ENSG00000093010, ENSG00000169083
Entacapone, Flopropione, Nitecapone, Phloroglucinol, Polyphloroglucinol phosphate, Tolcapone 386 4 0.0061E0 COMT cellular amine metabolic process, dopamine metabolic process, smooth muscle cell proliferation ENSG00000093010
Anhydrous caffeine 377 13 0.0061E0 ADORA1, ADORA2A, ADORA2B, PDE2A, PDE3A, PDE3B alpha-beta T cell activation, angiogenesis, apoptotic process, cAMP biosynthetic process, cGMP biosynthetic process, cardiac muscle contraction, cell adhesion mediated by integrin, glutamate secretion, hormone secretion, inflammatory response, lipid catabolic process, locomotion, protein import into nucleus, translocation, response to external stimulus, transcription from RNA polymerase II promoter ENSG00000128271, ENSG00000152270, ENSG00000163485, ENSG00000170425, ENSG00000172572, ENSG00000186642
Ibuprofen 387 3 0.0059E0 CFTR, PPARG acute inflammatory response, apoptotic process, cell development, cell growth, fat cell differentiation, fatty acid oxidation, interferon-gamma-mediated signaling pathway, macrophage derived foam cell differentiation, receptor biosynthetic process, response to external stimulus, sequestering of triglyceride, smooth muscle cell proliferation, transcription from RNA polymerase II promoter, vasodilation ENSG00000001626, ENSG00000132170
Bumetanide, Crofelemer, Glibenclamide 387 3 0.0059E0 CFTR vasodilation ENSG00000001626
Topiramate 382 8 0.005E0 CA2, CACNA1D, GRIK1, SCN5A calcium ion transport, cellular process, epithelial cell proliferation, gamma-aminobutyric acid secretion, intracellular pH reduction, sodium ion transport ENSG00000104267, ENSG00000157388, ENSG00000171189, ENSG00000183873
Tezampanel 382 8 0.005E0 GRIK1 gamma-aminobutyric acid secretion ENSG00000171189
Crenolanib 389 1 0.0045E0 PDGFRA, PDGFRB calcium ion import, chemotaxis, platelet activation ENSG00000113721, ENSG00000134853
Carfilzomib 378 12 0.0043E0 PSMB1, PSMB8, PSMB9 G1/S transition of mitotic cell cycle, cell cycle arrest, protein ubiquitination ENSG00000008018, ENSG00000204264, ENSG00000240065
Tyloxapol 387 3 0.0043E0 LPL macrophage derived foam cell differentiation, sequestering of triglyceride ENSG00000175445
Nicergoline 388 2 0.0043E0 ADRA1A, ADRA1B, ADRA1D MAPK cascade, cardiac muscle contraction, cell proliferation, cellular catabolic process, cellular process, glycogen catabolic process, heart contraction ENSG00000120907, ENSG00000170214, ENSG00000171873
Dapiprazole hydrochloride 388 2 0.0043E0 ADRA1A, ADRA1B, ADRA1D, ADRA2A, ADRA2B MAPK cascade, adrenergic receptor signaling pathway, amine transport, calcium ion-dependent exocytosis, cardiac muscle contraction, cell proliferation, cellular catabolic process, cellular process, epidermal growth factor receptor signaling pathway, glycogen catabolic process, heart contraction, lipid catabolic process, neuron differentiation, peptidyl-tyrosine phosphorylation ENSG00000120907, ENSG00000150594, ENSG00000170214, ENSG00000171873, ENSG00000222040
Sonepiprazole mesylate 389 1 0.0034E0 DRD4 MAPK cascade, amine transport, cAMP biosynthetic process, dopamine uptake involved in synaptic transmission, protein phosphorylation, protein secretion ENSG00000069696
Bromocriptine 389 1 0.0034E0 ADRA1A, ADRA1B, ADRA1D, ADRA2A, ADRA2B, DRD1, DRD2, DRD3, DRD4, HTR1A, HTR1B, HTR2A, HTR2B, HTR2C G-protein coupled receptor signaling pathway, I-kappaB kinase/NF-kappaB cascade, MAPK cascade, adrenergic receptor signaling pathway, amine transport, apoptotic process, autophagy, cAMP biosynthetic process, calcium ion-dependent exocytosis, cardiac muscle contraction, cell division, cell migration, cell proliferation, cellular carbohydrate metabolic process, cellular catabolic process, cellular process, cytokine secretion, diacylglycerol biosynthetic process, dopamine receptor signaling pathway, dopamine uptake involved in synaptic transmission, endothelial cell proliferation, epidermal growth factor receptor signaling pathway, glycogen catabolic process, growth hormone secretion, heart contraction, inositol trisphosphate biosynthetic process, lipid catabolic process, locomotion, neuron differentiation, oligodendrocyte differentiation, peptidyl-tyrosine phosphorylation, potassium ion transport, protein phosphorylation, protein secretion, response to external stimulus, sequestering of calcium ion, synaptic transmission, synaptic transmission, GABAergic, synaptic transmission, glutamatergic, vasoconstriction ENSG00000069696, ENSG00000102468, ENSG00000120907, ENSG00000135312, ENSG00000135914, ENSG00000147246, ENSG00000149295, ENSG00000150594, ENSG00000151577, ENSG00000170214, ENSG00000171873, ENSG00000178394, ENSG00000184845, ENSG00000222040
Guvacine, Tiagabine 385 5 0.0032E0 SLC6A1 gamma-aminobutyric acid secretion ENSG00000157103
Trimipramine 388 2 0.0031E0 ADRA1A, ADRA1B, HTR1A, HTR2A MAPK cascade, cardiac muscle contraction, cell proliferation, cellular carbohydrate metabolic process, cellular catabolic process, cellular process, glycogen catabolic process, heart contraction, inositol trisphosphate biosynthetic process, potassium ion transport, protein phosphorylation, sequestering of calcium ion, synaptic transmission, glutamatergic, vasoconstriction ENSG00000102468, ENSG00000120907, ENSG00000170214, ENSG00000178394
Maprotiline 388 2 0.0031E0 ADRA1A, CHRM1, CHRM2 cAMP metabolic process, cardiac muscle contraction, ion transport ENSG00000120907, ENSG00000168539, ENSG00000181072
Citalopram 388 2 0.0031E0 ADRA1A, CHRM1 cardiac muscle contraction, ion transport ENSG00000120907, ENSG00000168539
Dihydroergotoxine mesilate 388 2 0.0031E0 ADRA1A, ADRA2A adrenergic receptor signaling pathway, calcium ion-dependent exocytosis, cardiac muscle contraction, lipid catabolic process ENSG00000120907, ENSG00000150594
Fiduxosin hydrochloride 388 2 0.0031E0 ADRA1A cardiac muscle contraction ENSG00000120907
Dihydroergotoxine 388 2 0.0031E0 ADRA1A, ADRA2A, DRD1, GLUL, HTR2A MAPK cascade, adrenergic receptor signaling pathway, cAMP biosynthetic process, calcium ion-dependent exocytosis, cardiac muscle contraction, cell migration, cell proliferation, cellular carbohydrate metabolic process, epithelial cell proliferation, inositol trisphosphate biosynthetic process, insulin secretion, lipid catabolic process, potassium ion transport, protein phosphorylation, response to external stimulus, sequestering of calcium ion, synaptic transmission, synaptic transmission, glutamatergic, vasoconstriction ENSG00000102468, ENSG00000120907, ENSG00000135821, ENSG00000150594, ENSG00000184845
Bevantolol 388 2 0.0031E0 ADRA1A, ADRB1 cAMP biosynthetic process, cardiac muscle contraction, cell growth involved in cardiac muscle cell development, heart contraction, multicellular organism growth, multicellular organismal metabolic process, muscle organ development, saliva secretion, smooth muscle contraction ENSG00000043591, ENSG00000120907
Azilsartan, Azilsartan kamedoxomil, Azilsartan medoxomil, Candesartan, Eprosartan, Forasartan, Irbesartan, Losartan potassium, Olmesartan, Olmesartan medoxomil, Pratosartan, Saprisartan, Saralasin acetate, Tasosartan, Valsartan 385 5 0.0026E0 AGTR1 cholesterol esterification ENSG00000144891
Telmisartan 385 5 0.0026E0 AGTR1, PPARG acute inflammatory response, apoptotic process, cell development, cell growth, cholesterol esterification, fat cell differentiation, fatty acid oxidation, interferon-gamma-mediated signaling pathway, macrophage derived foam cell differentiation, receptor biosynthetic process, response to external stimulus, sequestering of triglyceride, smooth muscle cell proliferation, transcription from RNA polymerase II promoter ENSG00000132170, ENSG00000144891
Dilmapimod, Doramapimod, Losmapimod 389 1 0.0026E0 MAPK12, MAPK13, MAPK14 MAPK cascade, cell cycle, cell cycle phase transition, erythrocyte differentiation, inflammatory response, innate immune response, interleukin-6 production, muscle cell differentiation, protein import into nucleus, protein phosphorylation, reactive oxygen species metabolic process, response to external stimulus, transcription from RNA polymerase II promoter ENSG00000112062, ENSG00000156711, ENSG00000188130
Pamapimod, Talmapimod 389 1 0.0026E0 MAPK14 MAPK cascade, cell cycle phase transition, erythrocyte differentiation, innate immune response, muscle cell differentiation, protein import into nucleus, protein phosphorylation, reactive oxygen species metabolic process, transcription from RNA polymerase II promoter ENSG00000112062
Atorvastatin 389 1 0.0023E0 AHR, DPP4, HMGCR extracellular matrix disassembly, striated muscle cell apoptotic process, transcription from RNA polymerase II promoter ENSG00000106546, ENSG00000113161, ENSG00000197635
Atorvastatin calcium, Atorvastatin calcium hydrate, Cerivastatin sodium, Crilvastatin, Dalvastatin, Fluvastatin sodium, Lovastatin, Mevastatin, Pitavastatin calcium, Pravastatin sodium, Rosuvastatin calcium, Simvastatin, Tenivastatin calcium 389 1 0.0023E0 HMGCR striated muscle cell apoptotic process ENSG00000113161
Clodronate 380 10 0.0023E0 SLC25A4, SLC25A5 cell proliferation, cellular process, necrotic cell death ENSG00000005022, ENSG00000151729
Gallium nitrate 389 1 0.0022E0 IL1B JNK cascade, MAPK cascade, T cell proliferation, angiogenesis, apoptotic process, cell division, cell proliferation, cellular catabolic process, fever generation, heterotypic cell-cell adhesion, histone acetylation, insulin receptor signaling pathway, interferon-gamma production, interleukin-2 biosynthetic process, membrane protein ectodomain proteolysis, mitosis, nitric oxide biosynthetic process, protein catabolic process, protein export from nucleus, protein phosphorylation, response to external stimulus, transcription from RNA polymerase II promoter, vascular endothelial growth factor receptor signaling pathway ENSG00000125538
Ginseng 388 2 0.0019E0 AHR, IL6 B cell activation, DNA replication, ERK1 and ERK2 cascade, T cell proliferation, T-helper 2 cell differentiation, acute inflammatory response, apoptotic process, behavior, cell proliferation, cellular biosynthetic process, cellular carbohydrate metabolic process, chemokine production, collagen biosynthetic process, cytokine secretion, epithelial cell proliferation, fat cell differentiation, interleukin-6 production, leukocyte chemotaxis, lipid storage, muscle organ development, neuron differentiation, nitric oxide biosynthetic process, osteoblast differentiation, peptidyl-serine phosphorylation, protein import into nucleus, translocation, protein kinase B signaling cascade, protein phosphorylation, smooth muscle cell proliferation, transcription from RNA polymerase II promoter, translation, tyrosine phosphorylation of Stat3 protein ENSG00000106546, ENSG00000136244
Delanzomib, Marizomib 386 4 0.0016E0 PSMB1 G1/S transition of mitotic cell cycle, cell cycle arrest, protein ubiquitination ENSG00000008018
Navarixin, Reparixin 389 1 0.001E0 CXCR1, CXCR2 cAMP biosynthetic process, cell proliferation, cellular process ENSG00000163464, ENSG00000180871
Leflunomide 378 12 8.0E-4 AHR, DHODH, PTK2B B cell chemotaxis, JAK-STAT cascade, apoptotic process, protein ubiquitination involved in ubiquitin-dependent protein catabolic process, transcription from RNA polymerase II promoter ENSG00000102967, ENSG00000106546, ENSG00000120899
Atovaquone, Brequinar sodium, Teriflunomide 378 12 8.0E-4 DHODH apoptotic process ENSG00000102967
Miconazole 389 1 5.0E-4 KCNN4, NOS2, NOS3 T cell receptor signaling pathway, gene expression, killing of cells of other organism, leukocyte mediated cytotoxicity, platelet activation, protein catabolic process, protein secretion, vasodilation ENSG00000007171, ENSG00000104783, ENSG00000164867
Halothane 389 1 5.0E-4 GRIN2A, KCNN4 T cell receptor signaling pathway, apoptotic process, protein catabolic process, protein secretion ENSG00000104783, ENSG00000183454
Quinine 389 1 5.0E-4 KCNN4, SLC22A5 T cell receptor signaling pathway, intestinal epithelial structure maintenance, protein secretion ENSG00000104783, ENSG00000197375
Clotrimazole 389 1 5.0E-4 KCNN4 T cell receptor signaling pathway, protein secretion ENSG00000104783
Tofisopam 380 10 4.0E-4 PDE2A, PDE3A apoptotic process, cAMP biosynthetic process, inflammatory response, protein import into nucleus, translocation, response to external stimulus, transcription from RNA polymerase II promoter ENSG00000172572, ENSG00000186642
Adenosine monophosphate 389 1 3.0E-4 CREB1, FBP1, PRKAA1, PRKAB1 Ras protein signal transduction, cell cycle, cell growth, cellular carbohydrate metabolic process, cellular catabolic process, gene expression, glycolysis, hormone secretion, lipid biosynthetic process, lipid catabolic process ENSG00000111725, ENSG00000118260, ENSG00000132356, ENSG00000165140
Zonisamide 389 1 1.0E-4 CA2, CACNA1H, MAOB, SCN4B, SCN5A acrosome reaction, cellular amine metabolic process, cellular process, dopamine metabolic process, epithelial cell proliferation, intracellular pH reduction, serotonin secretion, sodium ion transport ENSG00000069535, ENSG00000104267, ENSG00000177098, ENSG00000183873, ENSG00000196557