Drug scores

Drugs fNeg fPos sum genes GOs Ensembl
Cipemastat 321 181 0.471E0 ADAM8 MAPK cascade, T cell differentiation in thymus, acute inflammatory response, bone resorption, cell adhesion, cellular catabolic process, eosinophil migration, innate immune response, membrane protein ectodomain proteolysis, neuron apoptotic process, neutrophil extravasation, protein catabolic process, protein kinase B signaling cascade, protein phosphorylation, protein processing, protein secretion, response to external stimulus ENSG00000151651
Pazopanib hydrochloride 291 211 0.4432E0 FGF1, FGFR3, ITK ERK1 and ERK2 cascade, apoptotic process, astrocyte differentiation, canonical Wnt receptor signaling pathway, cell development, cell differentiation, developmental growth, endothelial cell proliferation, epithelial cell proliferation, immune response, intracellular protein kinase cascade, lipid metabolic process, mitosis, protein ubiquitination, smoothened signaling pathway, transcription from RNA polymerase II promoter, tyrosine phosphorylation of Stat1 protein, tyrosine phosphorylation of Stat3 protein ENSG00000068078, ENSG00000113263, ENSG00000113578
Dovitinib lactate, Lenvatinib 328 174 0.4249E0 FGFR1, FGFR3 ERK1 and ERK2 cascade, MAPK cascade, apoptotic process, astrocyte differentiation, canonical Wnt receptor signaling pathway, cardiac muscle cell proliferation, cell cycle, cell development, cell differentiation, developmental growth, endothelial cell proliferation, epithelial cell proliferation, lipid metabolic process, mesenchymal cell proliferation, mitosis, neuron projection development, phosphatidylinositol 3-kinase cascade, protein phosphorylation, protein ubiquitination, smoothened signaling pathway, specification of organ identity, transcription from RNA polymerase II promoter, tyrosine phosphorylation of Stat1 protein, tyrosine phosphorylation of Stat3 protein ENSG00000068078, ENSG00000077782
Ponatinib 328 174 0.4249E0 ABL1, BCR, FGFR1, FGFR3, FLT3, LYN, RET B cell differentiation, ERK1 and ERK2 cascade, MAPK cascade, apoptotic process, astrocyte differentiation, canonical Wnt receptor signaling pathway, cardiac muscle cell proliferation, cell cycle, cell development, cell differentiation, cell migration, cell proliferation, cellular component organization, developmental growth, endothelial cell proliferation, epithelial cell proliferation, immune response, inflammatory response, lipid metabolic process, mesenchymal cell proliferation, metanephric glomerulus development, mitosis, muscle cell differentiation, neuron projection development, neutrophil degranulation, peptidyl-tyrosine phosphorylation, phagocytosis, phosphatidylinositol 3-kinase cascade, protein phosphorylation, protein ubiquitination, response to external stimulus, smoothened signaling pathway, specification of organ identity, toll-like receptor 2 signaling pathway, transcription from RNA polymerase II promoter, tyrosine phosphorylation of STAT protein, tyrosine phosphorylation of Stat1 protein, tyrosine phosphorylation of Stat3 protein ENSG00000068078, ENSG00000077782, ENSG00000097007, ENSG00000122025, ENSG00000165731, ENSG00000186716, ENSG00000254087
Amiloride 372 130 0.4147E0 PLAU, SLC9A1 blood coagulation, intracellular protein kinase cascade ENSG00000090020, ENSG00000122861
Erismodegib, Saridegib, Vismodegib 468 34 0.3044E0 SMO apoptotic process, branching involved in ureteric bud morphogenesis, cell development, epithelial cell differentiation, epithelial cell proliferation, hair follicle development, mesenchymal cell proliferation, neuroblast proliferation, protein import into nucleus, smoothened signaling pathway, transcription from RNA polymerase II promoter ENSG00000128602
Regorafenib 451 51 0.2356E0 ABL1, FGFR1, FRK, RET MAPK cascade, apoptotic process, cardiac muscle cell proliferation, cell cycle, cell proliferation, cellular process, immune response, mesenchymal cell proliferation, metanephric glomerulus development, muscle cell differentiation, neuron projection development, peptidyl-tyrosine phosphorylation, phosphatidylinositol 3-kinase cascade, protein phosphorylation, specification of organ identity, transcription from RNA polymerase II promoter ENSG00000077782, ENSG00000097007, ENSG00000111816, ENSG00000165731
Sorafenib 486 16 0.2341E0 FGFR1, FLT3, RET B cell differentiation, MAPK cascade, apoptotic process, cardiac muscle cell proliferation, cell cycle, cell proliferation, lipid metabolic process, mesenchymal cell proliferation, metanephric glomerulus development, neuron projection development, phosphatidylinositol 3-kinase cascade, protein phosphorylation, specification of organ identity, transcription from RNA polymerase II promoter ENSG00000077782, ENSG00000122025, ENSG00000165731
Brivanib, Brivanib alaninate 486 16 0.2341E0 FGFR1 MAPK cascade, apoptotic process, cardiac muscle cell proliferation, cell cycle, mesenchymal cell proliferation, neuron projection development, phosphatidylinositol 3-kinase cascade, protein phosphorylation, specification of organ identity, transcription from RNA polymerase II promoter ENSG00000077782
Nintedanib esylate 486 16 0.2341E0 FGFR1, FLT3 B cell differentiation, MAPK cascade, apoptotic process, cardiac muscle cell proliferation, cell cycle, cell proliferation, lipid metabolic process, mesenchymal cell proliferation, neuron projection development, phosphatidylinositol 3-kinase cascade, protein phosphorylation, specification of organ identity, transcription from RNA polymerase II promoter ENSG00000077782, ENSG00000122025
Clofarabine 461 41 0.192E0 RRM2B apoptotic process ENSG00000048392
Cladribine 461 41 0.192E0 PNP, RRM2B T cell proliferation, alpha-beta T cell differentiation, apoptotic process ENSG00000048392, ENSG00000198805
Vandetanib 446 56 0.1893E0 PTK6, VEGFA endothelial cell chemotaxis, growth, mast cell chemotaxis, peptidyl-tyrosine autophosphorylation ENSG00000101213, ENSG00000112715
Navitoclax 462 40 0.1826E0 BCL2A1, BCL2L1, MCL1 anoikis, apoptotic process, autophagy, cell proliferation, establishment of protein localization to plasma membrane, execution phase of apoptosis, intrinsic apoptotic signaling pathway, mitotic cell cycle phase transition, neuron apoptotic process, release of cytochrome c from mitochondria ENSG00000140379, ENSG00000143384, ENSG00000171552
Bosutinib 420 82 0.1698E0 ABL1, BCR, CDK2, MAP2K1, MAP3K2 G1/S transition of mitotic cell cycle, MAPK cascade, Ras protein signal transduction, apoptotic process, cell cycle, cell cycle arrest, cell differentiation, cell migration, cell proliferation, cellular component organization, immune response, inflammatory response, innate immune response, muscle cell differentiation, neutrophil degranulation, peptidyl-tyrosine phosphorylation, phagocytosis, protein phosphorylation, response to external stimulus, transcription elongation from RNA polymerase II promoter, transcription, DNA-dependent ENSG00000097007, ENSG00000123374, ENSG00000169032, ENSG00000169967, ENSG00000186716
Dinaciclib 421 81 0.1577E0 CDK2, CDK9 G1/S transition of mitotic cell cycle, cell cycle arrest, cell proliferation, transcription from RNA polymerase II promoter, transcription, DNA-dependent, viral transcription ENSG00000123374, ENSG00000136807
Sepantronium bromide 241 261 0.1545E0 BIRC5 cell cycle phase transition, cell proliferation, neuron apoptotic process, transcription, DNA-dependent ENSG00000089685
Flavopiridol, Hymenialdisine, Indirubin-3'-Monoxime, Olomoucine, SU9516 424 78 0.1541E0 CDK2 G1/S transition of mitotic cell cycle, cell cycle arrest, cell proliferation, transcription, DNA-dependent ENSG00000123374
Azacitidine, Decitabine 263 239 0.1436E0 DNMT1, DNMT3B, DNMT3L gene expression, histone H3-K4 methylation, histone H3-K9 methylation, transcription from RNA polymerase II promoter, transcription, DNA-dependent ENSG00000088305, ENSG00000130816, ENSG00000142182
Apilimod mesylate 487 15 0.1431E0 IL12A, IL12B, IL23A NK T cell proliferation, T cell differentiation, T cell mediated cytotoxicity, T cell proliferation, T-helper 1 type immune response, T-helper 17 cell lineage commitment, activated T cell proliferation, activation of JAK2 kinase activity, cell adhesion, cell cycle, cellular biosynthetic process, growth of symbiont in host, inflammatory response, interferon-gamma biosynthetic process, interferon-gamma production, interleukin-10 production, interleukin-12 production, macromolecule biosynthetic process, natural killer cell activation, osteoclast differentiation, response to external stimulus, smooth muscle cell proliferation, tissue remodeling, tyrosine phosphorylation of Stat3 protein, tyrosine phosphorylation of Stat5 protein ENSG00000110944, ENSG00000113302, ENSG00000168811
Antihemophilic Factor 481 21 0.1345E0 F2, PROC apoptotic process, blood coagulation, fibrinolysis, platelet activation, release of sequestered calcium ion into cytosol ENSG00000115718, ENSG00000180210
Sodium Tetradecyl Sulfate 481 21 0.1345E0 PROC apoptotic process, blood coagulation ENSG00000115718
Sotrastaurin 417 85 0.1295E0 PRKCD, PRKCE, PRKCH, PRKCQ B cell receptor signaling pathway, I-kappaB kinase/NF-kappaB cascade, MAPK cascade, T cell apoptotic process, T cell proliferation, T-helper 17 type immune response, actin filament polymerization, apoptotic process, cell development, cellular biosynthetic process, cellular carbohydrate metabolic process, cellular glucuronidation, ceramide biosynthetic process, cytokinesis, epithelial cell migration, fibroblast migration, glial cell proliferation, innate immune response, insulin receptor signaling pathway, insulin secretion, interleukin-2 biosynthetic process, interleukin-4 production, keratinocyte differentiation, macromolecule biosynthetic process, macrophage derived foam cell differentiation, platelet aggregation, sequestering of calcium ion, superoxide anion generation, synaptic transmission, GABAergic, wound healing ENSG00000027075, ENSG00000065675, ENSG00000163932, ENSG00000171132
Ertiprotafib, Tiludronate 459 43 0.1257E0 PTPN1 insulin receptor signaling pathway ENSG00000196396
Cariporide mesylate, Zoniporide mesylate 476 26 0.1131E0 SLC9A1 intracellular protein kinase cascade ENSG00000090020
Ellagic Acid 482 20 0.1047E0 PRKCB, SYK B cell differentiation, B cell receptor signaling pathway, I-kappaB kinase/NF-kappaB cascade, MAPK cascade, alpha-beta T cell differentiation, angiogenesis, bone resorption, calcium-mediated signaling, cell adhesion mediated by integrin, cellular biosynthetic process, cytokine secretion, immune response, insulin receptor signaling pathway, macromolecule biosynthetic process, mast cell degranulation, peptidyl-tyrosine phosphorylation, vascular endothelial growth factor receptor signaling pathway ENSG00000165025, ENSG00000166501
Hydroxychloroquine 496 6 0.0915E0 TLR7 cellular biosynthetic process, chemokine production, inflammatory response, innate immune response, interferon-gamma biosynthetic process, interleukin-6 production, macromolecule biosynthetic process, response to external stimulus ENSG00000196664
Rigosertib, Rigosertib sodium, Volasertib 466 36 0.0901E0 PLK1 apoptotic process, metaphase/anaphase transition of mitotic cell cycle, protein phosphorylation, protein ubiquitination, transcription from RNA polymerase II promoter ENSG00000166851
Anakinra 490 12 0.0865E0 IL1RN MAPK cascade, amine transport, apoptotic process, heterotypic cell-cell adhesion, protein phosphorylation ENSG00000136689
Terameprocol 429 73 0.0758E0 SP1 transcription from RNA polymerase II promoter, viral transcription ENSG00000185591
Abatacept 409 93 0.0754E0 CD80 T-helper 1 cell differentiation, alpha-beta T cell proliferation ENSG00000121594
Fostamatinib, Fostamatinib disodium 489 13 0.0712E0 SYK B cell differentiation, MAPK cascade, alpha-beta T cell differentiation, bone resorption, calcium-mediated signaling, cell adhesion mediated by integrin, cellular biosynthetic process, cytokine secretion, macromolecule biosynthetic process, mast cell degranulation, peptidyl-tyrosine phosphorylation ENSG00000165025
Fiboflapon, Fiboflapon sodium 484 18 0.0701E0 ALOX5AP acute inflammatory response, response to external stimulus ENSG00000132965
Tacrolimus 443 59 0.0695E0 CHP2, FKBP1A I-kappaB kinase/NF-kappaB cascade, calcineurin-NFAT signaling cascade, cell proliferation, protein import into nucleus, protein ubiquitination, transcription from RNA polymerase II promoter ENSG00000088832, ENSG00000166869
Arsenic trioxide 430 72 0.0667E0 AKT1, CCND1, MAPK1, MAPK3, TXNRD1 ERK1 and ERK2 cascade, G1/S transition of mitotic cell cycle, JNK cascade, T cell activation, Wnt receptor signaling pathway, autophagy, blood vessel endothelial cell migration, cell cycle, cell death, cell growth, epithelial cell differentiation, establishment of protein localization to plasma membrane, fat cell differentiation, glucose import, glycogen biosynthetic process, histone acetylation, innate immune response, nitric oxide biosynthetic process, peptidyl-serine phosphorylation, peptidyl-threonine phosphorylation, proteasomal ubiquitin-dependent protein catabolic process, protein phosphorylation, proteolysis, release of cytochrome c from mitochondria, sodium ion transport, transcription from RNA polymerase II promoter, vasoconstriction ENSG00000100030, ENSG00000102882, ENSG00000110092, ENSG00000142208, ENSG00000198431
Cobimetinib, Purvalanol 481 21 0.0544E0 MAPK1, MAPK3 ERK1 and ERK2 cascade, histone acetylation, innate immune response, peptidyl-threonine phosphorylation, transcription from RNA polymerase II promoter ENSG00000100030, ENSG00000102882
Avasimibe, Eldacimibe, Ezetimibe, Hesperetin 461 41 0.0536E0 SOAT1 glycoprotein biosynthetic process ENSG00000057252
Ribavirin 452 50 0.0516E0 ENPP1 cell growth, fat cell differentiation, glucose import, glycogen biosynthetic process, insulin receptor signaling pathway, ossification, protein autophosphorylation ENSG00000197594
Thalidomide 460 42 0.0515E0 NFKB1, TNF ERK1 and ERK2 cascade, JNK cascade, L-glutamate transport, amine transport, apoptotic process, carbohydrate metabolic process, cell proliferation, cellular catabolic process, cytokine secretion, fat cell differentiation, fever generation, glucose import, growth of symbiont in host, hair follicle development, heterotypic cell-cell adhesion, hyaluronan biosynthetic process, interferon-gamma production, interleukin-6 production, lipid storage, membrane protein ectodomain proteolysis, mitosis, necroptosis, neuron apoptotic process, nitric oxide biosynthetic process, osteoblast differentiation, osteoclast differentiation, peptidyl-serine phosphorylation, podosome assembly, protein catabolic process, protein kinase B signaling cascade, protein localization to cell surface, response to external stimulus, smooth muscle cell proliferation, synaptic transmission, transcription from RNA polymerase II promoter, translational initiation, viral genome replication ENSG00000109320, ENSG00000232810
Cenicriviroc 462 40 0.0495E0 CCR2, CCR5 T-helper 1 type immune response, angiogenesis, behavior, cAMP biosynthetic process, cellular biosynthetic process, inflammatory response, interferon-gamma production, interleukin-2 production, macromolecule biosynthetic process, sequestering of calcium ion, type 2 immune response ENSG00000121807, ENSG00000160791
Sulindac 492 10 0.0484E0 MAPK3, PPARD ERK1 and ERK2 cascade, cell proliferation, epithelial cell proliferation, fat cell differentiation, histone acetylation, innate immune response, phosphatidylinositol 3-kinase cascade, transcription from RNA polymerase II promoter, transcription, DNA-dependent ENSG00000102882, ENSG00000112033
Dasatinib 483 19 0.0476E0 ABL1, STAT5B, YES1 T cell activation, apoptotic process, immune response, muscle cell differentiation, natural killer cell differentiation, natural killer cell mediated cytotoxicity, peptidyl-tyrosine phosphorylation, protein phosphorylation ENSG00000097007, ENSG00000173757, ENSG00000176105
Dilmapimod, Doramapimod, Losmapimod 485 17 0.047E0 MAPK13, MAPK14 MAPK cascade, cell cycle phase transition, erythrocyte differentiation, inflammatory response, innate immune response, interleukin-6 production, muscle cell differentiation, protein import into nucleus, protein phosphorylation, reactive oxygen species metabolic process, response to external stimulus, transcription from RNA polymerase II promoter ENSG00000112062, ENSG00000156711
Aminosalicylic Acid 488 14 0.0416E0 CHUK, MPO I-kappaB kinase/NF-kappaB cascade, apoptotic process, growth of symbiont in host, innate immune response, type I interferon production ENSG00000005381, ENSG00000213341
Amrinone 467 35 0.0411E0 PDE3A, TNF ERK1 and ERK2 cascade, JNK cascade, L-glutamate transport, amine transport, apoptotic process, cell proliferation, cellular catabolic process, cytokine secretion, fat cell differentiation, fever generation, glucose import, growth of symbiont in host, hair follicle development, heterotypic cell-cell adhesion, interferon-gamma production, interleukin-6 production, lipid storage, membrane protein ectodomain proteolysis, mitosis, necroptosis, neuron apoptotic process, nitric oxide biosynthetic process, osteoblast differentiation, osteoclast differentiation, peptidyl-serine phosphorylation, podosome assembly, protein catabolic process, protein kinase B signaling cascade, protein localization to cell surface, response to external stimulus, smooth muscle cell proliferation, synaptic transmission, transcription from RNA polymerase II promoter, translational initiation, viral genome replication ENSG00000172572, ENSG00000232810
Lenalidomide 467 35 0.0394E0 TNF, TNFSF11 ERK1 and ERK2 cascade, I-kappaB kinase/NF-kappaB cascade, JNK cascade, L-glutamate transport, T cell activation, amine transport, apoptotic process, bone resorption, cell proliferation, cellular catabolic process, cytokine secretion, fat cell differentiation, fever generation, glucose import, growth of symbiont in host, hair follicle development, heterotypic cell-cell adhesion, interferon-gamma production, interleukin-6 production, lipid storage, membrane protein ectodomain proteolysis, mitosis, necroptosis, neuron apoptotic process, nitric oxide biosynthetic process, osteoblast differentiation, osteoclast differentiation, peptidyl-serine phosphorylation, podosome assembly, protein catabolic process, protein kinase B signaling cascade, protein localization to cell surface, protein phosphorylation, response to external stimulus, smooth muscle cell proliferation, synaptic transmission, transcription from RNA polymerase II promoter, translational initiation, viral genome replication ENSG00000120659, ENSG00000232810
Intravenous Immunoglobulin 495 7 0.0377E0 FCGR2A, FCGR3A immune response ENSG00000143226, ENSG00000203747
Cefdinir 477 25 0.0374E0 MPO, SLC22A5 apoptotic process, growth of symbiont in host, intestinal epithelial structure maintenance ENSG00000005381, ENSG00000197375
Ciclosporin, Voclosporin 488 14 0.0366E0 CHP2 calcineurin-NFAT signaling cascade, cell proliferation, protein import into nucleus, transcription from RNA polymerase II promoter ENSG00000166869
Pimecrolimus 488 14 0.0366E0 CHP2, FKBP1A, MTOR I-kappaB kinase/NF-kappaB cascade, T cell activation, actin filament polymerization, calcineurin-NFAT signaling cascade, cell proliferation, endothelial cell proliferation, macroautophagy, myotube differentiation, peptidyl-tyrosine phosphorylation, protein import into nucleus, protein kinase B signaling cascade, protein ubiquitination, stress fiber assembly, transcription from RNA polymerase II promoter, translation ENSG00000088832, ENSG00000166869, ENSG00000198793
Certolizumab pegol, Infliximab, Lenalidomide hydrate, Pomalidomide 468 34 0.0364E0 TNF ERK1 and ERK2 cascade, JNK cascade, L-glutamate transport, amine transport, apoptotic process, cell proliferation, cellular catabolic process, cytokine secretion, fat cell differentiation, fever generation, glucose import, growth of symbiont in host, hair follicle development, heterotypic cell-cell adhesion, interferon-gamma production, interleukin-6 production, lipid storage, membrane protein ectodomain proteolysis, mitosis, necroptosis, neuron apoptotic process, nitric oxide biosynthetic process, osteoblast differentiation, osteoclast differentiation, peptidyl-serine phosphorylation, podosome assembly, protein catabolic process, protein kinase B signaling cascade, protein localization to cell surface, response to external stimulus, smooth muscle cell proliferation, synaptic transmission, transcription from RNA polymerase II promoter, translational initiation, viral genome replication ENSG00000232810
Bleomycin 489 13 0.0357E0 LIG3 DNA recombination ENSG00000005156
Enzastaurin hydrochloride 492 10 0.0335E0 PRKCB B cell receptor signaling pathway, I-kappaB kinase/NF-kappaB cascade, angiogenesis, immune response, insulin receptor signaling pathway, vascular endothelial growth factor receptor signaling pathway ENSG00000166501
Carfilzomib 422 80 0.0308E0 PSMB1, PSMB9 G1/S transition of mitotic cell cycle, cell cycle arrest, protein ubiquitination ENSG00000008018, ENSG00000240065
Palbociclib 492 10 0.0294E0 CDK4, CDK6 apoptotic process, cellular senescence, fibroblast proliferation, translation ENSG00000105810, ENSG00000135446
Calcipotriol, Melatonin, Nabumetone, Tolmetin sodium 492 10 0.0273E0 MPO apoptotic process, growth of symbiont in host ENSG00000005381
Octreotide 492 10 0.0273E0 MPO, SSTR4 MAPK cascade, apoptotic process, cell proliferation, growth of symbiont in host ENSG00000005381, ENSG00000132671
Propylthiouracil 492 10 0.0273E0 DBH, MPO apoptotic process, growth of symbiont in host, vasoconstriction ENSG00000005381, ENSG00000123454
Bivalirudin 492 10 0.0273E0 F2, MPO apoptotic process, fibrinolysis, growth of symbiont in host, platelet activation, release of sequestered calcium ion into cytosol ENSG00000005381, ENSG00000180210
Clozapine, Olanzapine, Quetiapine fumarate 465 37 0.0266E0 ADRA1B, ADRA1D, ADRA2A, ADRA2B, CHRM1, CHRM2, DRD1, DRD2, HTR1A, HTR2C, HTR6 ERK1 and ERK2 cascade, G-protein coupled receptor signaling pathway, MAPK cascade, adrenergic receptor signaling pathway, amine transport, cAMP biosynthetic process, cAMP metabolic process, calcium ion-dependent exocytosis, cell development, cell migration, cell proliferation, cellular catabolic process, cellular component organization, cellular process, circadian sleep/wake cycle, sleep, dopamine uptake involved in synaptic transmission, epidermal growth factor receptor signaling pathway, glycogen catabolic process, heart contraction, insulin secretion, ion transport, lipid catabolic process, locomotion, multicellular organism growth, neuroblast proliferation, neuron differentiation, peptidyl-tyrosine phosphorylation, potassium ion transport, protein kinase B signaling cascade, protein phosphorylation, protein secretion, receptor internalization, response to external stimulus, sequestering of calcium ion, synaptic transmission, synaptic transmission, glutamatergic, transcription from RNA polymerase II promoter ENSG00000147246, ENSG00000149295, ENSG00000150594, ENSG00000158748, ENSG00000168539, ENSG00000170214, ENSG00000171873, ENSG00000178394, ENSG00000181072, ENSG00000184845, ENSG00000222040
Doxepin 466 36 0.0254E0 ADRA1B, ADRA1D, ADRA2A, ADRA2B, CHRM1, CHRM2, DRD2, HTR1A, HTR2C ERK1 and ERK2 cascade, G-protein coupled receptor signaling pathway, MAPK cascade, adrenergic receptor signaling pathway, amine transport, cAMP biosynthetic process, cAMP metabolic process, calcium ion-dependent exocytosis, cell development, cell migration, cell proliferation, cellular catabolic process, cellular component organization, cellular process, circadian sleep/wake cycle, sleep, dopamine uptake involved in synaptic transmission, epidermal growth factor receptor signaling pathway, glycogen catabolic process, heart contraction, insulin secretion, ion transport, lipid catabolic process, locomotion, multicellular organism growth, neuroblast proliferation, neuron differentiation, peptidyl-tyrosine phosphorylation, protein kinase B signaling cascade, protein phosphorylation, protein secretion, receptor internalization, response to external stimulus, sequestering of calcium ion, synaptic transmission, glutamatergic, transcription from RNA polymerase II promoter ENSG00000147246, ENSG00000149295, ENSG00000150594, ENSG00000168539, ENSG00000170214, ENSG00000171873, ENSG00000178394, ENSG00000181072, ENSG00000222040
Levomepromazine 467 35 0.0253E0 ADRA1B, ADRA1D, ADRA2A, ADRA2B, CHRM1, CHRM2, DRD1, DRD2, HTR2C ERK1 and ERK2 cascade, G-protein coupled receptor signaling pathway, MAPK cascade, adrenergic receptor signaling pathway, amine transport, cAMP biosynthetic process, cAMP metabolic process, calcium ion-dependent exocytosis, cell development, cell migration, cell proliferation, cellular catabolic process, cellular component organization, cellular process, circadian sleep/wake cycle, sleep, dopamine uptake involved in synaptic transmission, epidermal growth factor receptor signaling pathway, glycogen catabolic process, heart contraction, insulin secretion, ion transport, lipid catabolic process, locomotion, multicellular organism growth, neuroblast proliferation, neuron differentiation, peptidyl-tyrosine phosphorylation, potassium ion transport, protein kinase B signaling cascade, protein phosphorylation, protein secretion, receptor internalization, response to external stimulus, sequestering of calcium ion, synaptic transmission, synaptic transmission, glutamatergic, transcription from RNA polymerase II promoter ENSG00000147246, ENSG00000149295, ENSG00000150594, ENSG00000168539, ENSG00000170214, ENSG00000171873, ENSG00000181072, ENSG00000184845, ENSG00000222040
Bicalutamide, Cyproterone, Cyproterone acetate, Drospirenone, Enzalutamide, Flutamide, Nilutamide, Oxendolone, Spironolactone 496 6 0.0253E0 AR MAPK cascade, apoptotic process, cell proliferation, epithelial cell proliferation, insulin-like growth factor receptor signaling pathway, intracellular estrogen receptor signaling pathway, phosphorylation, transcription from RNA polymerase II promoter ENSG00000169083
Framycetin, Plerixafor 489 13 0.0249E0 CXCR4 MAPK cascade, cell development, protein phosphorylation ENSG00000121966
Dantrolene sodium hydrate, Procaine 492 10 0.0244E0 RYR2 cardiac muscle contraction, transport ENSG00000198626
Lapatinib 313 189 0.0242E0 ERBB2, TAP1 MAPK cascade, T cell mediated cytotoxicity, cell adhesion, cell growth, epithelial cell proliferation, protein phosphorylation, transcription from RNA polymerase I promoter, translation ENSG00000141736, ENSG00000168394
Pentosan Polysulfate 493 9 0.0233E0 FGF1, FGF4 ERK1 and ERK2 cascade, apoptotic process, cell differentiation, cell division, cell proliferation, intracellular protein kinase cascade, protein phosphorylation, transcription from RNA polymerase II promoter ENSG00000075388, ENSG00000113578
Metamfetamine 474 28 0.0231E0 ADRA2A, ADRA2B, MAOB, SLC18A2, SLC22A5 MAPK cascade, adrenergic receptor signaling pathway, amine transport, calcium ion-dependent exocytosis, cellular amine metabolic process, dopamine metabolic process, epidermal growth factor receptor signaling pathway, intestinal epithelial structure maintenance, lipid catabolic process, neuron differentiation, neurotransmitter transport, peptidyl-tyrosine phosphorylation, serotonin secretion ENSG00000069535, ENSG00000150594, ENSG00000165646, ENSG00000197375, ENSG00000222040
Afatinib, Canertinib dihydrochloride, Dacomitinib, Varlitinib 451 51 0.0225E0 ERBB2, ERBB4 ERK1 and ERK2 cascade, MAPK cascade, apoptotic process, cardiac muscle cell proliferation, cell adhesion, cell growth, cell proliferation, epithelial cell proliferation, lipid metabolic process, protein phosphorylation, transcription from RNA polymerase I promoter, transcription, DNA-dependent, translation, tyrosine phosphorylation of Stat5 protein ENSG00000141736, ENSG00000178568
Desipramine 459 43 0.0211E0 CHRM1, CHRM2, SLC22A5 cAMP metabolic process, intestinal epithelial structure maintenance, ion transport ENSG00000168539, ENSG00000181072, ENSG00000197375
Nicotine 479 23 0.0203E0 MAOB, SLC22A5 cellular amine metabolic process, dopamine metabolic process, intestinal epithelial structure maintenance, serotonin secretion ENSG00000069535, ENSG00000197375
Nortriptyline 468 34 0.0203E0 ADRA1D, CHRM1, CHRM2, HTR1A cAMP metabolic process, cell proliferation, cellular process, heart contraction, ion transport ENSG00000168539, ENSG00000171873, ENSG00000178394, ENSG00000181072
Amitriptyline 468 34 0.0202E0 ADRA1D, ADRA2A, CHRM1, CHRM2, NTRK2 MAPK cascade, adrenergic receptor signaling pathway, anoikis, axonogenesis, cAMP biosynthetic process, cAMP metabolic process, calcium ion-dependent exocytosis, cell proliferation, cellular process, gene expression, heart contraction, ion transport, lipid catabolic process, neuron apoptotic process, phosphatidylinositol 3-kinase cascade, synaptic transmission, glutamatergic ENSG00000148053, ENSG00000150594, ENSG00000168539, ENSG00000171873, ENSG00000181072
Nicardipine 469 33 0.0202E0 ADRA1B, ADRA1D, CACNA1D, CACNB2, CHRM1, CHRM2 MAPK cascade, cAMP metabolic process, calcium ion transport, cell proliferation, cellular catabolic process, cellular process, glycogen catabolic process, heart contraction, ion transport ENSG00000157388, ENSG00000165995, ENSG00000168539, ENSG00000170214, ENSG00000171873, ENSG00000181072
Promazine hydrochloride, Propiomazine 469 33 0.0202E0 ADRA1B, ADRA1D, CHRM1, CHRM2, DRD1, DRD2, HTR2C ERK1 and ERK2 cascade, G-protein coupled receptor signaling pathway, MAPK cascade, amine transport, cAMP biosynthetic process, cAMP metabolic process, cell development, cell migration, cell proliferation, cellular catabolic process, cellular component organization, cellular process, circadian sleep/wake cycle, sleep, dopamine uptake involved in synaptic transmission, glycogen catabolic process, heart contraction, insulin secretion, ion transport, locomotion, multicellular organism growth, neuroblast proliferation, potassium ion transport, protein kinase B signaling cascade, protein phosphorylation, protein secretion, receptor internalization, response to external stimulus, sequestering of calcium ion, synaptic transmission, synaptic transmission, glutamatergic, transcription from RNA polymerase II promoter ENSG00000147246, ENSG00000149295, ENSG00000168539, ENSG00000170214, ENSG00000171873, ENSG00000181072, ENSG00000184845
Imipramine 469 33 0.0202E0 ADRA1D, CHRM1, CHRM2 cAMP metabolic process, cell proliferation, cellular process, heart contraction, ion transport ENSG00000168539, ENSG00000171873, ENSG00000181072
Adrenaline 482 20 0.0195E0 ADRA1B, ADRA1D, ADRA2A, ADRA2B, ADRB1, SLC22A5 MAPK cascade, adrenergic receptor signaling pathway, amine transport, cAMP biosynthetic process, calcium ion-dependent exocytosis, cell growth involved in cardiac muscle cell development, cell proliferation, cellular catabolic process, cellular process, epidermal growth factor receptor signaling pathway, glycogen catabolic process, heart contraction, intestinal epithelial structure maintenance, lipid catabolic process, multicellular organism growth, multicellular organismal metabolic process, muscle organ development, neuron differentiation, peptidyl-tyrosine phosphorylation, saliva secretion, smooth muscle contraction ENSG00000043591, ENSG00000150594, ENSG00000170214, ENSG00000171873, ENSG00000197375, ENSG00000222040
Asenapine maleate 485 17 0.0189E0 ADRA1B, ADRA1D, ADRA2A, ADRA2B, ADRB1, DRD1, DRD2, HTR1A, HTR1F, HTR2C, HTR6 ERK1 and ERK2 cascade, G-protein coupled receptor signaling pathway, MAPK cascade, adrenergic receptor signaling pathway, amine transport, cAMP biosynthetic process, cAMP metabolic process, calcium ion-dependent exocytosis, cell development, cell growth involved in cardiac muscle cell development, cell migration, cell proliferation, cellular catabolic process, cellular component organization, cellular process, circadian sleep/wake cycle, sleep, dopamine uptake involved in synaptic transmission, epidermal growth factor receptor signaling pathway, glycogen catabolic process, heart contraction, insulin secretion, lipid catabolic process, locomotion, multicellular organism growth, multicellular organismal metabolic process, muscle organ development, neuroblast proliferation, neuron differentiation, peptidyl-tyrosine phosphorylation, potassium ion transport, protein kinase B signaling cascade, protein phosphorylation, protein secretion, receptor internalization, response to external stimulus, saliva secretion, sequestering of calcium ion, smooth muscle contraction, synaptic transmission, synaptic transmission, glutamatergic, transcription from RNA polymerase II promoter ENSG00000043591, ENSG00000147246, ENSG00000149295, ENSG00000150594, ENSG00000158748, ENSG00000170214, ENSG00000171873, ENSG00000178394, ENSG00000179097, ENSG00000184845, ENSG00000222040
Troglitazone 492 10 0.0184E0 SERPINE1 angiogenesis, apoptotic process, behavior, blood coagulation, cell adhesion mediated by integrin, cellular component organization, receptor-mediated endocytosis, response to external stimulus, smooth muscle cell migration, transcription from RNA polymerase II promoter ENSG00000106366
Mianserin 486 16 0.0177E0 ADRA1B, ADRA1D, ADRA2A, ADRA2B, HTR1A, HTR1F, HTR2C MAPK cascade, adrenergic receptor signaling pathway, amine transport, cAMP metabolic process, calcium ion-dependent exocytosis, cell proliferation, cellular catabolic process, cellular process, epidermal growth factor receptor signaling pathway, glycogen catabolic process, heart contraction, lipid catabolic process, locomotion, neuron differentiation, peptidyl-tyrosine phosphorylation ENSG00000147246, ENSG00000150594, ENSG00000170214, ENSG00000171873, ENSG00000178394, ENSG00000179097, ENSG00000222040
Cilengitide 496 6 0.0175E0 ITGAV, ITGB3 apoptotic process, cell adhesion, cell migration, cellular component organization, endothelial cell migration, endothelial cell proliferation, lipid storage, lipid transport, macrophage derived foam cell differentiation, osteoblast proliferation, peptidyl-tyrosine phosphorylation, phagocytosis, vascular endothelial growth factor receptor signaling pathway ENSG00000138448, ENSG00000259207
Ziprasidone 470 32 0.0173E0 ADRA1B, ADRA2A, ADRA2B, CHRM1, CHRM2, DRD1, DRD2, HTR1A, HTR2C, HTR6 ERK1 and ERK2 cascade, G-protein coupled receptor signaling pathway, MAPK cascade, adrenergic receptor signaling pathway, amine transport, cAMP biosynthetic process, cAMP metabolic process, calcium ion-dependent exocytosis, cell development, cell migration, cell proliferation, cellular catabolic process, cellular component organization, cellular process, circadian sleep/wake cycle, sleep, dopamine uptake involved in synaptic transmission, epidermal growth factor receptor signaling pathway, glycogen catabolic process, heart contraction, insulin secretion, ion transport, lipid catabolic process, locomotion, multicellular organism growth, neuroblast proliferation, neuron differentiation, peptidyl-tyrosine phosphorylation, potassium ion transport, protein kinase B signaling cascade, protein phosphorylation, protein secretion, receptor internalization, response to external stimulus, sequestering of calcium ion, synaptic transmission, synaptic transmission, glutamatergic, transcription from RNA polymerase II promoter ENSG00000147246, ENSG00000149295, ENSG00000150594, ENSG00000158748, ENSG00000168539, ENSG00000170214, ENSG00000178394, ENSG00000181072, ENSG00000184845, ENSG00000222040
Aripiprazole 471 31 0.0172E0 ADRA1B, ADRA2A, ADRA2B, CHRM1, CHRM2, DRD1, DRD2, HTR1A, HTR2C, HTR6 ERK1 and ERK2 cascade, G-protein coupled receptor signaling pathway, MAPK cascade, adrenergic receptor signaling pathway, amine transport, cAMP biosynthetic process, cAMP metabolic process, calcium ion-dependent exocytosis, cell development, cell migration, cell proliferation, cellular catabolic process, cellular component organization, cellular process, circadian sleep/wake cycle, sleep, dopamine uptake involved in synaptic transmission, epidermal growth factor receptor signaling pathway, glycogen catabolic process, heart contraction, insulin secretion, ion transport, lipid catabolic process, locomotion, multicellular organism growth, neuroblast proliferation, neuron differentiation, peptidyl-tyrosine phosphorylation, potassium ion transport, protein kinase B signaling cascade, protein phosphorylation, protein secretion, receptor internalization, response to external stimulus, sequestering of calcium ion, synaptic transmission, synaptic transmission, glutamatergic, transcription from RNA polymerase II promoter ENSG00000147246, ENSG00000149295, ENSG00000150594, ENSG00000158748, ENSG00000168539, ENSG00000170214, ENSG00000178394, ENSG00000181072, ENSG00000184845, ENSG00000222040
Gallamine triethiodide 468 34 0.0168E0 ACHE, CHRM2 cAMP metabolic process, protein secretion, synaptic transmission, cholinergic ENSG00000087085, ENSG00000181072
Chlorpromazine 471 31 0.0161E0 ADRA1B, ADRA2A, ADRA2B, CHRM1, CHRM2, DRD1, DRD2, HTR1A, HTR2C ERK1 and ERK2 cascade, G-protein coupled receptor signaling pathway, MAPK cascade, adrenergic receptor signaling pathway, amine transport, cAMP biosynthetic process, cAMP metabolic process, calcium ion-dependent exocytosis, cell development, cell migration, cell proliferation, cellular catabolic process, cellular component organization, cellular process, circadian sleep/wake cycle, sleep, dopamine uptake involved in synaptic transmission, epidermal growth factor receptor signaling pathway, glycogen catabolic process, heart contraction, insulin secretion, ion transport, lipid catabolic process, locomotion, multicellular organism growth, neuroblast proliferation, neuron differentiation, peptidyl-tyrosine phosphorylation, potassium ion transport, protein kinase B signaling cascade, protein phosphorylation, protein secretion, receptor internalization, response to external stimulus, sequestering of calcium ion, synaptic transmission, synaptic transmission, glutamatergic, transcription from RNA polymerase II promoter ENSG00000147246, ENSG00000149295, ENSG00000150594, ENSG00000168539, ENSG00000170214, ENSG00000178394, ENSG00000181072, ENSG00000184845, ENSG00000222040
Chlorpromazine tannate 472 30 0.016E0 ADRA2A, ADRA2B, CHRM1, CHRM2, DRD2, HTR2C ERK1 and ERK2 cascade, G-protein coupled receptor signaling pathway, MAPK cascade, adrenergic receptor signaling pathway, amine transport, cAMP biosynthetic process, cAMP metabolic process, calcium ion-dependent exocytosis, cell development, cell migration, cell proliferation, cellular component organization, circadian sleep/wake cycle, sleep, dopamine uptake involved in synaptic transmission, epidermal growth factor receptor signaling pathway, insulin secretion, ion transport, lipid catabolic process, locomotion, multicellular organism growth, neuroblast proliferation, neuron differentiation, peptidyl-tyrosine phosphorylation, protein kinase B signaling cascade, protein phosphorylation, protein secretion, receptor internalization, response to external stimulus, sequestering of calcium ion, synaptic transmission, glutamatergic, transcription from RNA polymerase II promoter ENSG00000147246, ENSG00000149295, ENSG00000150594, ENSG00000168539, ENSG00000181072, ENSG00000222040
Ladostigil tartrate 488 14 0.016E0 ACHE, MAOB cellular amine metabolic process, dopamine metabolic process, protein secretion, serotonin secretion, synaptic transmission, cholinergic ENSG00000069535, ENSG00000087085
Flavoxate 473 29 0.0156E0 CHRM1, CHRM2, PDE3A apoptotic process, cAMP metabolic process, ion transport ENSG00000168539, ENSG00000172572, ENSG00000181072
Leflunomide 494 8 0.015E0 DHODH, PTK2B B cell chemotaxis, JAK-STAT cascade, apoptotic process, protein ubiquitination involved in ubiquitin-dependent protein catabolic process ENSG00000102967, ENSG00000120899
Triflusal 493 9 0.015E0 NFKB1, NOS2 carbohydrate metabolic process, gene expression, hyaluronan biosynthetic process, killing of cells of other organism, leukocyte mediated cytotoxicity, protein catabolic process, vasodilation ENSG00000007171, ENSG00000109320
Cilastatin sodium 455 47 0.015E0 DPEP1 apoptotic process, cell migration ENSG00000015413
Acamprosate calcium 497 5 0.0144E0 GRIN2A, GRIN2C, GRM1, GRM5 G-protein coupled receptor signaling pathway, MAPK cascade, apoptotic process, cell development, neurogenesis, protein catabolic process, protein phosphorylation ENSG00000152822, ENSG00000161509, ENSG00000168959, ENSG00000183454
Setiptiline 495 7 0.0144E0 ADRA1B, ADRA1D, ADRA2A, ADRA2B, HTR2C MAPK cascade, adrenergic receptor signaling pathway, amine transport, calcium ion-dependent exocytosis, cell proliferation, cellular catabolic process, cellular process, epidermal growth factor receptor signaling pathway, glycogen catabolic process, heart contraction, lipid catabolic process, locomotion, neuron differentiation, peptidyl-tyrosine phosphorylation ENSG00000147246, ENSG00000150594, ENSG00000170214, ENSG00000171873, ENSG00000222040
Phenoxybenzamine 495 7 0.0144E0 ADRA1B, ADRA1D, ADRA2A, ADRA2B, CALM3 MAPK cascade, adrenergic receptor signaling pathway, amine transport, calcium ion-dependent exocytosis, cell proliferation, cellular catabolic process, cellular process, epidermal growth factor receptor signaling pathway, glycogen catabolic process, heart contraction, lipid catabolic process, neuron differentiation, peptidyl-tyrosine phosphorylation, transport ENSG00000150594, ENSG00000160014, ENSG00000170214, ENSG00000171873, ENSG00000222040
Phentolamine, Tolazoline 495 7 0.0144E0 ADRA1B, ADRA1D, ADRA2A, ADRA2B MAPK cascade, adrenergic receptor signaling pathway, amine transport, calcium ion-dependent exocytosis, cell proliferation, cellular catabolic process, cellular process, epidermal growth factor receptor signaling pathway, glycogen catabolic process, heart contraction, lipid catabolic process, neuron differentiation, peptidyl-tyrosine phosphorylation ENSG00000150594, ENSG00000170214, ENSG00000171873, ENSG00000222040
Mesalazine, Salazosulfapyridine 498 4 0.0143E0 CHUK I-kappaB kinase/NF-kappaB cascade, innate immune response, type I interferon production ENSG00000213341
Celecoxib 492 10 0.0143E0 PDPK1 T cell activation, cardiac muscle cell apoptotic process, establishment of protein localization to plasma membrane, immune effector process, immune response, protein phosphorylation, transforming growth factor beta receptor signaling pathway ENSG00000140992
Bortezomib 463 39 0.0141E0 PSMB1, PSMD1, PSMD2 G1/S transition of mitotic cell cycle, cell cycle arrest, protein ubiquitination ENSG00000008018, ENSG00000173692, ENSG00000175166
Mubritinib, Neratinib 451 51 0.0138E0 ERBB2 MAPK cascade, cell adhesion, cell growth, epithelial cell proliferation, protein phosphorylation, transcription from RNA polymerase I promoter, translation ENSG00000141736
Ephedra 489 13 0.0129E0 ADRA2A, ADRA2B, ADRB1, MAOB, SLC18A2 MAPK cascade, adrenergic receptor signaling pathway, amine transport, cAMP biosynthetic process, calcium ion-dependent exocytosis, cell growth involved in cardiac muscle cell development, cellular amine metabolic process, dopamine metabolic process, epidermal growth factor receptor signaling pathway, heart contraction, lipid catabolic process, multicellular organism growth, multicellular organismal metabolic process, muscle organ development, neuron differentiation, neurotransmitter transport, peptidyl-tyrosine phosphorylation, saliva secretion, serotonin secretion, smooth muscle contraction ENSG00000043591, ENSG00000069535, ENSG00000150594, ENSG00000165646, ENSG00000222040
MMDA 489 13 0.0129E0 MAOB, SLC18A2 cellular amine metabolic process, dopamine metabolic process, neurotransmitter transport, serotonin secretion ENSG00000069535, ENSG00000165646
4-Methoxyamphetamine 489 13 0.0129E0 ADRA2A, MAOB, SLC18A2 adrenergic receptor signaling pathway, calcium ion-dependent exocytosis, cellular amine metabolic process, dopamine metabolic process, lipid catabolic process, neurotransmitter transport, serotonin secretion ENSG00000069535, ENSG00000150594, ENSG00000165646
Amphetamine sulfate 482 20 0.0129E0 CARTPT, SLC18A2, SLC22A5 amine transport, bone resorption, intestinal epithelial structure maintenance, neurotransmitter transport, osteoclast differentiation, protein phosphorylation, transmission of nerve impulse ENSG00000164326, ENSG00000165646, ENSG00000197375
Ibalizumab 501 1 0.0126E0 CD4 T cell activation, calcium-mediated signaling, cellular biosynthetic process, immune response, interleukin-2 biosynthetic process, macromolecule biosynthetic process, peptidyl-tyrosine phosphorylation ENSG00000010610
Ronacaleret hydrochloride 499 3 0.0125E0 CASR cell proliferation, cellular process, gene expression ENSG00000036828
Azilsartan, Azilsartan kamedoxomil, Azilsartan medoxomil, Candesartan, Eprosartan, Forasartan, Irbesartan, Losartan potassium, Olmesartan, Olmesartan medoxomil, Pratosartan, Saprisartan, Saralasin acetate, Tasosartan, Telmisartan, Valsartan 471 31 0.0124E0 AGTR1 cholesterol esterification ENSG00000144891
Vitamin E 489 13 0.0116E0 GSTO1, GSTP1, HMOX1, NQO1 I-kappaB kinase/NF-kappaB cascade, angiogenesis, cellular biosynthetic process, immune effector process, leukocyte migration, leukocyte proliferation, macromolecule biosynthetic process, mast cell degranulation, neuron apoptotic process, smooth muscle cell proliferation, striated muscle contraction, superoxide anion generation, tumor necrosis factor-mediated signaling pathway, vasodilation ENSG00000084207, ENSG00000100292, ENSG00000148834, ENSG00000181019
Aclidinium bromide, Alvameline maleate, Atropine, Benzatropine, Benzetimide, Benzquinamide, Benztropine mesilate, Biperiden, Brompheniramine, Butropium bromide, Cimetropium bromide, Cocaine, Cryptenamine, Cyclopentolate, Darifenacin, Darotropium bromide, Dexetimide, Dicyclomine hydrochloride, Diphenidol, Diphenylpiperidinomethyldioxolan iodide, Diponium bromide, Disopyramide, Esoxybutynin chloride, Ethybenztropine, Etomidoline, Eucatropine hydrochloride, Fentonium bromide, Fesoterodine, Flutropium bromide, Hexocyclium metilsulfate, Homatropine hydrobromide, Homatropine methylbromide, Hyoscine methobromide, Hyoscyamine, Ipratropium bromide hydrate, Isopropamide iodide, Maprotiline, Mazaticol, Mepenzolate bromide, Methanthelinium bromide, Methylbenactyzium bromide, Methyloctatropine bromide, Metixene, Orphenadrine, Oxapium iodide, Oxitropium bromide, Oxybutynin, Oxyphencyclimine, Paroxetine, Piperidolate, Pipethanate, Pipethanate ethobromide, Piroheptine, Prifinium bromide, Procyclidine, Profenamine, Propantheline bromide, Propiverine, Scopolamine, Scopolamine butylbromide, Solifenacin, Tiemonium, Timepidium bromide hydrate, Tiotropium, Tolterodine, Tridihexethyl chloride, Trihexyphenidyl, Trimebutine, Tropicamide, Trospium chloride, Umeclidinium, Valethamate bromide 474 28 0.0109E0 CHRM1, CHRM2 cAMP metabolic process, ion transport ENSG00000168539, ENSG00000181072
Triflupromazine 474 28 0.0109E0 CHRM1, CHRM2, DRD1, DRD2 ERK1 and ERK2 cascade, G-protein coupled receptor signaling pathway, amine transport, cAMP biosynthetic process, cAMP metabolic process, cell development, cell migration, cell proliferation, cellular component organization, circadian sleep/wake cycle, sleep, dopamine uptake involved in synaptic transmission, insulin secretion, ion transport, multicellular organism growth, neuroblast proliferation, potassium ion transport, protein kinase B signaling cascade, protein phosphorylation, protein secretion, receptor internalization, response to external stimulus, sequestering of calcium ion, synaptic transmission, synaptic transmission, glutamatergic, transcription from RNA polymerase II promoter ENSG00000149295, ENSG00000168539, ENSG00000181072, ENSG00000184845
Promethazine 474 28 0.0109E0 CALM3, CHRM1, CHRM2, DRD2 ERK1 and ERK2 cascade, G-protein coupled receptor signaling pathway, amine transport, cAMP biosynthetic process, cAMP metabolic process, cell development, cell migration, cell proliferation, cellular component organization, circadian sleep/wake cycle, sleep, dopamine uptake involved in synaptic transmission, insulin secretion, ion transport, multicellular organism growth, neuroblast proliferation, protein kinase B signaling cascade, protein phosphorylation, protein secretion, receptor internalization, response to external stimulus, sequestering of calcium ion, synaptic transmission, glutamatergic, transcription from RNA polymerase II promoter, transport ENSG00000149295, ENSG00000160014, ENSG00000168539, ENSG00000181072
Dimetindene, Doxacurium chloride, Metocurine, Pancuronium, Pipecuronium, Rocuronium bromide 474 28 0.0109E0 CHRM2 cAMP metabolic process ENSG00000181072
Cyproheptadine hydrochloride 474 28 0.0109E0 CHRM1, CHRM2, HTR2C cAMP metabolic process, ion transport, locomotion ENSG00000147246, ENSG00000168539, ENSG00000181072
Chlorprothixene 474 28 0.0109E0 CHRM1, CHRM2, DRD1, DRD2, HTR2C ERK1 and ERK2 cascade, G-protein coupled receptor signaling pathway, amine transport, cAMP biosynthetic process, cAMP metabolic process, cell development, cell migration, cell proliferation, cellular component organization, circadian sleep/wake cycle, sleep, dopamine uptake involved in synaptic transmission, insulin secretion, ion transport, locomotion, multicellular organism growth, neuroblast proliferation, potassium ion transport, protein kinase B signaling cascade, protein phosphorylation, protein secretion, receptor internalization, response to external stimulus, sequestering of calcium ion, synaptic transmission, synaptic transmission, glutamatergic, transcription from RNA polymerase II promoter ENSG00000147246, ENSG00000149295, ENSG00000168539, ENSG00000181072, ENSG00000184845
Valproic acid 486 16 0.0108E0 CACNA1H, HDAC5, HDAC6, HDAC7, HDAC8, SLC22A5 acrosome reaction, apoptotic process, cell migration involved in sprouting angiogenesis, cellular protein metabolic process, epithelial cell migration, interleukin-2 production, intestinal epithelial structure maintenance, microtubule depolymerization, myotube differentiation, osteoblast differentiation, proteolysis, receptor biosynthetic process, signal transduction, transcription from RNA polymerase II promoter, transcription, DNA-dependent ENSG00000061273, ENSG00000094631, ENSG00000108840, ENSG00000147099, ENSG00000196557, ENSG00000197375
Quinine 486 16 0.0105E0 KCNN4, SLC22A5 T cell receptor signaling pathway, intestinal epithelial structure maintenance, protein secretion ENSG00000104783, ENSG00000197375
Sertindole 496 6 0.0105E0 ADRA1B, ADRA1D, DRD2, HTR2C, HTR6 ERK1 and ERK2 cascade, G-protein coupled receptor signaling pathway, MAPK cascade, amine transport, cAMP biosynthetic process, cell development, cell migration, cell proliferation, cellular catabolic process, cellular component organization, cellular process, circadian sleep/wake cycle, sleep, dopamine uptake involved in synaptic transmission, glycogen catabolic process, heart contraction, insulin secretion, locomotion, multicellular organism growth, neuroblast proliferation, protein kinase B signaling cascade, protein phosphorylation, protein secretion, receptor internalization, response to external stimulus, sequestering of calcium ion, synaptic transmission, synaptic transmission, glutamatergic, transcription from RNA polymerase II promoter ENSG00000147246, ENSG00000149295, ENSG00000158748, ENSG00000170214, ENSG00000171873
Nandrolone decanoate 494 8 0.0102E0 AR, MAOB MAPK cascade, apoptotic process, cell proliferation, cellular amine metabolic process, dopamine metabolic process, epithelial cell proliferation, insulin-like growth factor receptor signaling pathway, intracellular estrogen receptor signaling pathway, phosphorylation, serotonin secretion, transcription from RNA polymerase II promoter ENSG00000069535, ENSG00000169083
Amantadine 494 8 0.0102E0 DRD2, GRIN2A, MAOB ERK1 and ERK2 cascade, G-protein coupled receptor signaling pathway, amine transport, apoptotic process, cAMP biosynthetic process, cell development, cell migration, cell proliferation, cellular amine metabolic process, cellular component organization, circadian sleep/wake cycle, sleep, dopamine metabolic process, dopamine uptake involved in synaptic transmission, insulin secretion, multicellular organism growth, neuroblast proliferation, protein catabolic process, protein kinase B signaling cascade, protein phosphorylation, protein secretion, receptor internalization, response to external stimulus, sequestering of calcium ion, serotonin secretion, synaptic transmission, glutamatergic, transcription from RNA polymerase II promoter ENSG00000069535, ENSG00000149295, ENSG00000183454
Rasagiline 494 8 0.0102E0 BCL2, MAOB B cell proliferation, anoikis, apoptotic signaling pathway, autophagy, calcium ion transport into cytosol, cell growth, cell migration, cellular amine metabolic process, dopamine metabolic process, immune response, intracellular pH reduction, intrinsic apoptotic signaling pathway, melanocyte differentiation, mitotic cell cycle, multicellular organism growth, neuron apoptotic process, ossification, osteoblast proliferation, peptidyl-serine phosphorylation, serotonin secretion, skeletal muscle fiber development, smooth muscle cell migration ENSG00000069535, ENSG00000171791
Amezinium metilsulfate, Caroxazone, Etryptamine acetate, Furazolidone, Iproclozide, Iproniazid, Isocarboxazid, Isoniazid, Isoniazid glucuronate sodium, Lazabemide, Linezolid, Milacemide hydrochloride, Mofegiline hydrochloride, Nialamide, Pargyline, Phenelzine, Phentermine, Safinamide, Safrazine hydrochloride, Selegiline, Tranylcypromine sulfate, Zimelidine 494 8 0.0102E0 MAOB cellular amine metabolic process, dopamine metabolic process, serotonin secretion ENSG00000069535
Zonisamide 494 8 0.0102E0 CACNA1H, MAOB acrosome reaction, cellular amine metabolic process, dopamine metabolic process, serotonin secretion ENSG00000069535, ENSG00000196557
Noradrenaline 487 15 0.0101E0 ADRA1B, ADRA1D, ADRA2A, ADRA2B, ADRB1, SLC22A5 MAPK cascade, adrenergic receptor signaling pathway, amine transport, cAMP biosynthetic process, calcium ion-dependent exocytosis, cell growth involved in cardiac muscle cell development, cell proliferation, cellular catabolic process, cellular process, epidermal growth factor receptor signaling pathway, glycogen catabolic process, heart contraction, intestinal epithelial structure maintenance, lipid catabolic process, multicellular organism growth, multicellular organismal metabolic process, muscle organ development, neuron differentiation, peptidyl-tyrosine phosphorylation, saliva secretion, smooth muscle contraction ENSG00000043591, ENSG00000150594, ENSG00000170214, ENSG00000171873, ENSG00000197375, ENSG00000222040
Lomefloxacin, Norfloxacin, Ofloxacin, Sparfloxacin 487 15 0.0101E0 SLC22A5, TOP2A apoptotic process, intestinal epithelial structure maintenance, transcription from RNA polymerase II promoter ENSG00000131747, ENSG00000197375
Acetylcholine, Ampicillin, Azidocillin, Benzylpenicillin potassium, Cefadroxil, Cefalexin, Cefalotin, Cefepime, Cefixime, Cefradine, Ceftazidime, Cephaloglycin, Choline, Cimetidine, Creatine, Cyclacillin, Dactinomycin, Diphenhydramine, Furosemide, Grepafloxacin, Guanidine, Histamine Phosphate, L-Arginine, Lidocaine, Niacin, Probenecid, Procainamide, Quinidine, Sodium p-aminophippurate, Thiamine 487 15 0.0101E0 SLC22A5 intestinal epithelial structure maintenance ENSG00000197375
Clonidine 487 15 0.0101E0 ADRA2A, ADRA2B, SLC22A5 MAPK cascade, adrenergic receptor signaling pathway, amine transport, calcium ion-dependent exocytosis, epidermal growth factor receptor signaling pathway, intestinal epithelial structure maintenance, lipid catabolic process, neuron differentiation, peptidyl-tyrosine phosphorylation ENSG00000150594, ENSG00000197375, ENSG00000222040
Verapamil 487 15 0.0101E0 CACNA1D, CACNB2, SLC22A5 calcium ion transport, intestinal epithelial structure maintenance ENSG00000157388, ENSG00000165995, ENSG00000197375
Dopamine 487 15 0.0101E0 DRD1, DRD2, SLC22A5 ERK1 and ERK2 cascade, G-protein coupled receptor signaling pathway, amine transport, cAMP biosynthetic process, cell development, cell migration, cell proliferation, cellular component organization, circadian sleep/wake cycle, sleep, dopamine uptake involved in synaptic transmission, insulin secretion, intestinal epithelial structure maintenance, multicellular organism growth, neuroblast proliferation, potassium ion transport, protein kinase B signaling cascade, protein phosphorylation, protein secretion, receptor internalization, response to external stimulus, sequestering of calcium ion, synaptic transmission, synaptic transmission, glutamatergic, transcription from RNA polymerase II promoter ENSG00000149295, ENSG00000184845, ENSG00000197375
Aldosterone 487 15 0.0101E0 CYP17A1, SLC22A5 cellular biosynthetic process, hormone biosynthetic process, intestinal epithelial structure maintenance ENSG00000148795, ENSG00000197375
Guvacine, Tiagabine 482 20 0.0098E0 SLC6A1 gamma-aminobutyric acid secretion ENSG00000157103
Navarixin, Reparixin 491 11 0.0094E0 CXCR1, CXCR2 cAMP biosynthetic process, cell proliferation, cellular process ENSG00000163464, ENSG00000180871
Risperidone 495 7 0.0094E0 ADRA1B, ADRA1D, ADRA2A, ADRA2B, DRD1, DRD2, HTR1A, HTR2C ERK1 and ERK2 cascade, G-protein coupled receptor signaling pathway, MAPK cascade, adrenergic receptor signaling pathway, amine transport, cAMP biosynthetic process, calcium ion-dependent exocytosis, cell development, cell migration, cell proliferation, cellular catabolic process, cellular component organization, cellular process, circadian sleep/wake cycle, sleep, dopamine uptake involved in synaptic transmission, epidermal growth factor receptor signaling pathway, glycogen catabolic process, heart contraction, insulin secretion, lipid catabolic process, locomotion, multicellular organism growth, neuroblast proliferation, neuron differentiation, peptidyl-tyrosine phosphorylation, potassium ion transport, protein kinase B signaling cascade, protein phosphorylation, protein secretion, receptor internalization, response to external stimulus, sequestering of calcium ion, synaptic transmission, synaptic transmission, glutamatergic, transcription from RNA polymerase II promoter ENSG00000147246, ENSG00000149295, ENSG00000150594, ENSG00000170214, ENSG00000171873, ENSG00000178394, ENSG00000184845, ENSG00000222040
Ergotamine tartrate 497 5 0.0093E0 ADRA1B, ADRA1D, ADRA2A, ADRA2B, DRD2 ERK1 and ERK2 cascade, G-protein coupled receptor signaling pathway, MAPK cascade, adrenergic receptor signaling pathway, amine transport, cAMP biosynthetic process, calcium ion-dependent exocytosis, cell development, cell migration, cell proliferation, cellular catabolic process, cellular component organization, cellular process, circadian sleep/wake cycle, sleep, dopamine uptake involved in synaptic transmission, epidermal growth factor receptor signaling pathway, glycogen catabolic process, heart contraction, insulin secretion, lipid catabolic process, multicellular organism growth, neuroblast proliferation, neuron differentiation, peptidyl-tyrosine phosphorylation, protein kinase B signaling cascade, protein phosphorylation, protein secretion, receptor internalization, response to external stimulus, sequestering of calcium ion, synaptic transmission, glutamatergic, transcription from RNA polymerase II promoter ENSG00000149295, ENSG00000150594, ENSG00000170214, ENSG00000171873, ENSG00000222040
Pelanserin hydrochloride 497 5 0.0093E0 ADRA1B, ADRA1D, HTR2C MAPK cascade, cell proliferation, cellular catabolic process, cellular process, glycogen catabolic process, heart contraction, locomotion ENSG00000147246, ENSG00000170214, ENSG00000171873
Dapiprazole hydrochloride 497 5 0.0093E0 ADRA1B, ADRA1D, ADRA2A, ADRA2B MAPK cascade, adrenergic receptor signaling pathway, amine transport, calcium ion-dependent exocytosis, cell proliferation, cellular catabolic process, cellular process, epidermal growth factor receptor signaling pathway, glycogen catabolic process, heart contraction, lipid catabolic process, neuron differentiation, peptidyl-tyrosine phosphorylation ENSG00000150594, ENSG00000170214, ENSG00000171873, ENSG00000222040
Alfuzosin, Bunazosin, Doxazosin, Ifenprodil, Ifenprodil tartrate, Indoramin, Ketanserin, Moxisylyte, Naftopidil, Nicergoline, Prazosin, Silodosin, Tamsulosin, Terazosin, Trimazosin, Urapidil 497 5 0.0093E0 ADRA1B, ADRA1D MAPK cascade, cell proliferation, cellular catabolic process, cellular process, glycogen catabolic process, heart contraction ENSG00000170214, ENSG00000171873
Pimozide 497 5 0.0093E0 ADRA1B, ADRA1D, CALM3, DRD2 ERK1 and ERK2 cascade, G-protein coupled receptor signaling pathway, MAPK cascade, amine transport, cAMP biosynthetic process, cell development, cell migration, cell proliferation, cellular catabolic process, cellular component organization, cellular process, circadian sleep/wake cycle, sleep, dopamine uptake involved in synaptic transmission, glycogen catabolic process, heart contraction, insulin secretion, multicellular organism growth, neuroblast proliferation, protein kinase B signaling cascade, protein phosphorylation, protein secretion, receptor internalization, response to external stimulus, sequestering of calcium ion, synaptic transmission, glutamatergic, transcription from RNA polymerase II promoter, transport ENSG00000149295, ENSG00000160014, ENSG00000170214, ENSG00000171873
Carvedilol 497 5 0.0093E0 ADRA1B, ADRA1D, ADRB1, VCAM1 MAPK cascade, T cell proliferation, cAMP biosynthetic process, cell growth involved in cardiac muscle cell development, cell proliferation, cellular catabolic process, cellular process, glycogen catabolic process, heart contraction, multicellular organism growth, multicellular organismal metabolic process, muscle organ development, saliva secretion, smooth muscle contraction ENSG00000043591, ENSG00000162692, ENSG00000170214, ENSG00000171873
Lipoic Acid 500 2 0.0093E0 POR apoptotic process, cellular biosynthetic process, cholesterol biosynthetic process, chondrocyte differentiation, hormone biosynthetic process, smoothened signaling pathway ENSG00000127948
Amosulalol, Arotinolol, Bunitrolol hydrochloride, Labetalol hydrochloride, Levobunolol, Medroxalol, Nipradilol 497 5 0.0093E0 ADRA1B, ADRA1D, ADRB1 MAPK cascade, cAMP biosynthetic process, cell growth involved in cardiac muscle cell development, cell proliferation, cellular catabolic process, cellular process, glycogen catabolic process, heart contraction, multicellular organism growth, multicellular organismal metabolic process, muscle organ development, saliva secretion, smooth muscle contraction ENSG00000043591, ENSG00000170214, ENSG00000171873
Pimasertib, Selumetinib, Trametinib 501 1 0.0092E0 MAP2K1 MAPK cascade, Ras protein signal transduction, cell cycle, cell differentiation, cell migration, cell proliferation, innate immune response, protein phosphorylation, transcription elongation from RNA polymerase II promoter ENSG00000169032
Fasudil, Fasudil hydrochloride hydrate 497 5 0.0092E0 ROCK1, ROCK2 angiogenesis, neuron apoptotic process ENSG00000067900, ENSG00000134318
Ancriviroc, Aplaviroc hydrochloride, Maraviroc, Vicriviroc maleate 469 33 0.0089E0 CCR5 cAMP biosynthetic process, sequestering of calcium ion ENSG00000160791
Abiraterone acetate, Galeterone, Ketoconazole, Liarozole fumarate, Liarozole hydrochloride, Mitotane, Orteronel, Progesterone 500 2 0.0088E0 CYP17A1 cellular biosynthetic process, hormone biosynthetic process ENSG00000148795
Dexamethasone 500 2 0.0088E0 CYP17A1, NOS2 cellular biosynthetic process, gene expression, hormone biosynthetic process, killing of cells of other organism, leukocyte mediated cytotoxicity, protein catabolic process, vasodilation ENSG00000007171, ENSG00000148795
Metoclopramide 500 2 0.0088E0 CHRM1, CYP17A1, DRD2 ERK1 and ERK2 cascade, G-protein coupled receptor signaling pathway, amine transport, cAMP biosynthetic process, cell development, cell migration, cell proliferation, cellular biosynthetic process, cellular component organization, circadian sleep/wake cycle, sleep, dopamine uptake involved in synaptic transmission, hormone biosynthetic process, insulin secretion, ion transport, multicellular organism growth, neuroblast proliferation, protein kinase B signaling cascade, protein phosphorylation, protein secretion, receptor internalization, response to external stimulus, sequestering of calcium ion, synaptic transmission, glutamatergic, transcription from RNA polymerase II promoter ENSG00000148795, ENSG00000149295, ENSG00000168539
Clomipramine 492 10 0.0082E0 GSTP1, HTR2C leukocyte proliferation, locomotion, superoxide anion generation, tumor necrosis factor-mediated signaling pathway ENSG00000084207, ENSG00000147246
Ezatiostat hydrochloride 492 10 0.0082E0 GSTP1 leukocyte proliferation, superoxide anion generation, tumor necrosis factor-mediated signaling pathway ENSG00000084207
Suramin hexasodium 496 6 0.0075E0 CFTR, P2RX2, P2RX7, RYR2 MAPK cascade, T cell mediated cytotoxicity, amine transport, apoptotic process, bone mineralization, bone resorption, calcium ion transport into cytosol, calcium-mediated signaling, cardiac muscle contraction, interleukin-1 beta secretion, interleukin-6 production, protein phosphorylation, sequestering of calcium ion, transport, vasodilation ENSG00000001626, ENSG00000089041, ENSG00000187848, ENSG00000198626
Quinacrine 501 1 0.0074E0 PLA2G6 arachidonic acid secretion, exocytosis, immune response, protein kinase C signaling cascade, protein phosphorylation, release of cytochrome c from mitochondria, synaptic transmission, glutamatergic, vasodilation ENSG00000184381
Latrepirdine 495 7 0.007E0 ACHE, GRIN2A, GRIN2C, HTR6 amine transport, apoptotic process, protein catabolic process, protein secretion, synaptic transmission, synaptic transmission, cholinergic ENSG00000087085, ENSG00000158748, ENSG00000161509, ENSG00000183454
Velneperit 497 5 0.0063E0 NPY5R acute inflammatory response, amine transport, cellular process, response to external stimulus, smooth muscle cell proliferation, synaptic transmission, GABAergic ENSG00000164129
Fenobam, Rufinamide 500 2 0.0061E0 GRM5 G-protein coupled receptor signaling pathway, cell development, neurogenesis, protein phosphorylation ENSG00000168959
Ambenonium chloride, Besipirdine hydrochloride, Caracemide, Decamethonium, Demecarium bromide, Dimetacrine, Distigmine bromide, Donepezil, Ecothiopate iodide, Edrophonium chloride, Galantamine, Icopezil maleate, Ipidacrine hydrochloride hydrate, Isoflurophate, Itopride, Mefloquine, Neostigmine, Physostigmine, Physostigmine sulfate, Pyridostigmine bromide, Rivastigmine, Tacrine, Tubocurarine chloride hydrate, Velnacrine maleate, Zanapezil fumarate 496 6 0.0058E0 ACHE protein secretion, synaptic transmission, cholinergic ENSG00000087085
Minaprine 496 6 0.0058E0 ACHE, CHRM1, DRD1, DRD2, HTR2C ERK1 and ERK2 cascade, G-protein coupled receptor signaling pathway, amine transport, cAMP biosynthetic process, cell development, cell migration, cell proliferation, cellular component organization, circadian sleep/wake cycle, sleep, dopamine uptake involved in synaptic transmission, insulin secretion, ion transport, locomotion, multicellular organism growth, neuroblast proliferation, potassium ion transport, protein kinase B signaling cascade, protein phosphorylation, protein secretion, receptor internalization, response to external stimulus, sequestering of calcium ion, synaptic transmission, synaptic transmission, cholinergic, synaptic transmission, glutamatergic, transcription from RNA polymerase II promoter ENSG00000087085, ENSG00000147246, ENSG00000149295, ENSG00000168539, ENSG00000184845
Acotiamide hydrochloride hydrate 496 6 0.0058E0 ACHE, CHRM1 ion transport, protein secretion, synaptic transmission, cholinergic ENSG00000087085, ENSG00000168539
Deltibant, Icatibant acetate 501 1 0.0053E0 BDKRB2 apoptotic process, peptidyl-serine phosphorylation ENSG00000168398
Pamapimod, Talmapimod 501 1 0.0052E0 MAPK14 MAPK cascade, cell cycle phase transition, erythrocyte differentiation, innate immune response, muscle cell differentiation, protein import into nucleus, protein phosphorylation, reactive oxygen species metabolic process, transcription from RNA polymerase II promoter ENSG00000112062
Paliperidone 499 3 0.0052E0 ADRA1B, ADRA2A, ADRA2B, DRD1, DRD2, HTR1A, HTR2C ERK1 and ERK2 cascade, G-protein coupled receptor signaling pathway, MAPK cascade, adrenergic receptor signaling pathway, amine transport, cAMP biosynthetic process, calcium ion-dependent exocytosis, cell development, cell migration, cell proliferation, cellular catabolic process, cellular component organization, cellular process, circadian sleep/wake cycle, sleep, dopamine uptake involved in synaptic transmission, epidermal growth factor receptor signaling pathway, glycogen catabolic process, heart contraction, insulin secretion, lipid catabolic process, locomotion, multicellular organism growth, neuroblast proliferation, neuron differentiation, peptidyl-tyrosine phosphorylation, potassium ion transport, protein kinase B signaling cascade, protein phosphorylation, protein secretion, receptor internalization, response to external stimulus, sequestering of calcium ion, synaptic transmission, synaptic transmission, glutamatergic, transcription from RNA polymerase II promoter ENSG00000147246, ENSG00000149295, ENSG00000150594, ENSG00000170214, ENSG00000178394, ENSG00000184845, ENSG00000222040
Imiloxan hydrochloride 501 1 0.0051E0 ADRA2B MAPK cascade, amine transport, epidermal growth factor receptor signaling pathway, neuron differentiation, peptidyl-tyrosine phosphorylation ENSG00000222040
Piribedil 500 2 0.0051E0 ADRA2A, ADRA2B, DRD2 ERK1 and ERK2 cascade, G-protein coupled receptor signaling pathway, MAPK cascade, adrenergic receptor signaling pathway, amine transport, cAMP biosynthetic process, calcium ion-dependent exocytosis, cell development, cell migration, cell proliferation, cellular component organization, circadian sleep/wake cycle, sleep, dopamine uptake involved in synaptic transmission, epidermal growth factor receptor signaling pathway, insulin secretion, lipid catabolic process, multicellular organism growth, neuroblast proliferation, neuron differentiation, peptidyl-tyrosine phosphorylation, protein kinase B signaling cascade, protein phosphorylation, protein secretion, receptor internalization, response to external stimulus, sequestering of calcium ion, synaptic transmission, glutamatergic, transcription from RNA polymerase II promoter ENSG00000149295, ENSG00000150594, ENSG00000222040
Rotigotine 501 1 0.0051E0 ADRA2B, DRD1, DRD2, HTR1A ERK1 and ERK2 cascade, G-protein coupled receptor signaling pathway, MAPK cascade, amine transport, cAMP biosynthetic process, cell development, cell migration, cell proliferation, cellular component organization, cellular process, circadian sleep/wake cycle, sleep, dopamine uptake involved in synaptic transmission, epidermal growth factor receptor signaling pathway, insulin secretion, multicellular organism growth, neuroblast proliferation, neuron differentiation, peptidyl-tyrosine phosphorylation, potassium ion transport, protein kinase B signaling cascade, protein phosphorylation, protein secretion, receptor internalization, response to external stimulus, sequestering of calcium ion, synaptic transmission, synaptic transmission, glutamatergic, transcription from RNA polymerase II promoter ENSG00000149295, ENSG00000178394, ENSG00000184845, ENSG00000222040
Yohimbine 500 2 0.0051E0 ADRA2A, ADRA2B, DRD2, HTR1A, HTR2C ERK1 and ERK2 cascade, G-protein coupled receptor signaling pathway, MAPK cascade, adrenergic receptor signaling pathway, amine transport, cAMP biosynthetic process, calcium ion-dependent exocytosis, cell development, cell migration, cell proliferation, cellular component organization, cellular process, circadian sleep/wake cycle, sleep, dopamine uptake involved in synaptic transmission, epidermal growth factor receptor signaling pathway, insulin secretion, lipid catabolic process, locomotion, multicellular organism growth, neuroblast proliferation, neuron differentiation, peptidyl-tyrosine phosphorylation, protein kinase B signaling cascade, protein phosphorylation, protein secretion, receptor internalization, response to external stimulus, sequestering of calcium ion, synaptic transmission, glutamatergic, transcription from RNA polymerase II promoter ENSG00000147246, ENSG00000149295, ENSG00000150594, ENSG00000178394, ENSG00000222040
Mirtazapine 500 2 0.0051E0 ADRA2A, ADRA2B, HTR2C MAPK cascade, adrenergic receptor signaling pathway, amine transport, calcium ion-dependent exocytosis, epidermal growth factor receptor signaling pathway, lipid catabolic process, locomotion, neuron differentiation, peptidyl-tyrosine phosphorylation ENSG00000147246, ENSG00000150594, ENSG00000222040
Cabergoline 500 2 0.0051E0 ADRA2A, ADRA2B, DRD1, DRD2, HTR1A, HTR2C ERK1 and ERK2 cascade, G-protein coupled receptor signaling pathway, MAPK cascade, adrenergic receptor signaling pathway, amine transport, cAMP biosynthetic process, calcium ion-dependent exocytosis, cell development, cell migration, cell proliferation, cellular component organization, cellular process, circadian sleep/wake cycle, sleep, dopamine uptake involved in synaptic transmission, epidermal growth factor receptor signaling pathway, insulin secretion, lipid catabolic process, locomotion, multicellular organism growth, neuroblast proliferation, neuron differentiation, peptidyl-tyrosine phosphorylation, potassium ion transport, protein kinase B signaling cascade, protein phosphorylation, protein secretion, receptor internalization, response to external stimulus, sequestering of calcium ion, synaptic transmission, synaptic transmission, glutamatergic, transcription from RNA polymerase II promoter ENSG00000147246, ENSG00000149295, ENSG00000150594, ENSG00000178394, ENSG00000184845, ENSG00000222040
Fenoldopam mesylate 500 2 0.0051E0 ADRA2A, ADRA2B, DRD1 MAPK cascade, adrenergic receptor signaling pathway, amine transport, cAMP biosynthetic process, calcium ion-dependent exocytosis, cell migration, epidermal growth factor receptor signaling pathway, lipid catabolic process, neuron differentiation, peptidyl-tyrosine phosphorylation, potassium ion transport, response to external stimulus, synaptic transmission, synaptic transmission, glutamatergic ENSG00000150594, ENSG00000184845, ENSG00000222040
Aptazapine maleate, Atipamezole, Delequamine hydrochloride, Fluparoxan hydrochloride 500 2 0.0051E0 ADRA2A, ADRA2B MAPK cascade, adrenergic receptor signaling pathway, amine transport, calcium ion-dependent exocytosis, epidermal growth factor receptor signaling pathway, lipid catabolic process, neuron differentiation, peptidyl-tyrosine phosphorylation ENSG00000150594, ENSG00000222040
Aminophylline, Anhydrous caffeine, Choline theophylline, Proxyphylline 501 1 0.0047E0 ADORA1, PDE3A apoptotic process, cardiac muscle contraction, glutamate secretion, hormone secretion, lipid catabolic process ENSG00000163485, ENSG00000172572
Theophylline 501 1 0.0047E0 ADA, ADORA1, PDE3A B cell proliferation, T cell differentiation in thymus, T cell receptor signaling pathway, adenosine receptor signaling pathway, alpha-beta T cell differentiation, apoptotic process, calcium-mediated signaling, cardiac muscle contraction, germinal center formation, glutamate secretion, heart contraction, hormone secretion, inflammatory response, leukocyte migration, lipid catabolic process, penile erection, response to external stimulus, smooth muscle contraction ENSG00000163485, ENSG00000172572, ENSG00000196839
Anagrelide, Cilostazol, Enoximone, Ibudilast, Imazodan hydrochloride, Inamrinone lactate, Indolidan, Isomazole hydrochloride, Levosimendan, Lixazinone sulfate, Milrinone, Moxaverine, Olprinone, Papaverine, Papaverine sulfate, Pimobendan, Propentofylline, Tibenelast sodium, Toborinone, Tofisopam, Trapidil, Vesnarinone 501 1 0.0047E0 PDE3A apoptotic process ENSG00000172572
Beradilol monoethyl maleate 501 1 0.0047E0 ADRB1, PDE3A apoptotic process, cAMP biosynthetic process, cell growth involved in cardiac muscle cell development, heart contraction, multicellular organism growth, multicellular organismal metabolic process, muscle organ development, saliva secretion, smooth muscle contraction ENSG00000043591, ENSG00000172572
Bumetanide, Crofelemer, Glibenclamide, Ibuprofen 499 3 0.0045E0 CFTR vasodilation ENSG00000001626
Metergoline 492 10 0.0044E0 HTR1A, HTR1F, HTR2C, HTR6 amine transport, cAMP metabolic process, cell proliferation, cellular process, locomotion, synaptic transmission ENSG00000147246, ENSG00000158748, ENSG00000178394, ENSG00000179097
Amlexanox 501 1 0.0044E0 FGF1 intracellular protein kinase cascade ENSG00000113578
Pizotifen malate, Pizotyline 493 9 0.0033E0 HTR1A, HTR1F, HTR2C cAMP metabolic process, cell proliferation, cellular process, locomotion ENSG00000147246, ENSG00000178394, ENSG00000179097
3,4-Methylenedioxymethamphetamine, Tedatioxetine 497 5 0.0028E0 HTR2C, SLC18A2 locomotion, neurotransmitter transport ENSG00000147246, ENSG00000165646
Tetrabenazine 497 5 0.0028E0 DRD2, SLC18A2 ERK1 and ERK2 cascade, G-protein coupled receptor signaling pathway, amine transport, cAMP biosynthetic process, cell development, cell migration, cell proliferation, cellular component organization, circadian sleep/wake cycle, sleep, dopamine uptake involved in synaptic transmission, insulin secretion, multicellular organism growth, neuroblast proliferation, neurotransmitter transport, protein kinase B signaling cascade, protein phosphorylation, protein secretion, receptor internalization, response to external stimulus, sequestering of calcium ion, synaptic transmission, glutamatergic, transcription from RNA polymerase II promoter ENSG00000149295, ENSG00000165646
Ephedrine 497 5 0.0028E0 ADRA1B, ADRA1D, ADRA2A, ADRA2B, ADRB1, SLC18A2 MAPK cascade, adrenergic receptor signaling pathway, amine transport, cAMP biosynthetic process, calcium ion-dependent exocytosis, cell growth involved in cardiac muscle cell development, cell proliferation, cellular catabolic process, cellular process, epidermal growth factor receptor signaling pathway, glycogen catabolic process, heart contraction, lipid catabolic process, multicellular organism growth, multicellular organismal metabolic process, muscle organ development, neuron differentiation, neurotransmitter transport, peptidyl-tyrosine phosphorylation, saliva secretion, smooth muscle contraction ENSG00000043591, ENSG00000150594, ENSG00000165646, ENSG00000170214, ENSG00000171873, ENSG00000222040
Alseroxylon, Deserpidine, Isometheptene, Reserpine 497 5 0.0028E0 SLC18A2 neurotransmitter transport ENSG00000165646
L-Tryptophan 448 54 0.0019E0 WARS cell proliferation, cellular process ENSG00000140105
Nedocromil, Pranlukast hydrate 500 2 0.0018E0 CYSLTR2 ERK1 and ERK2 cascade, angiogenesis, cell death ENSG00000152207
Pranlukast 500 2 0.0018E0 CYSLTR2, IL5 B cell proliferation, ERK1 and ERK2 cascade, angiogenesis, cell death, peptidyl-tyrosine phosphorylation, podosome assembly, transcription, DNA-dependent ENSG00000113525, ENSG00000152207
Diazoxide, L-Methionine, Pegvisomant, Picrotoxin 500 2 0.0014E0 GLUL epithelial cell proliferation, insulin secretion, synaptic transmission, glutamatergic ENSG00000135821
Ethyl biscoumacetate 500 2 0.0014E0 GLUL, NQO1 epithelial cell proliferation, insulin secretion, neuron apoptotic process, synaptic transmission, glutamatergic ENSG00000135821, ENSG00000181019
Adenosine monophosphate 495 7 0.0014E0 FBP1, PRKAA1, PRKAB1 Ras protein signal transduction, cell cycle, cell growth, cellular carbohydrate metabolic process, cellular catabolic process, gene expression, glycolysis, lipid catabolic process ENSG00000111725, ENSG00000132356, ENSG00000165140
Iloperidone 500 2 0.0012E0 DRD1, DRD2, HTR1A, HTR6 ERK1 and ERK2 cascade, G-protein coupled receptor signaling pathway, amine transport, cAMP biosynthetic process, cell development, cell migration, cell proliferation, cellular component organization, cellular process, circadian sleep/wake cycle, sleep, dopamine uptake involved in synaptic transmission, insulin secretion, multicellular organism growth, neuroblast proliferation, potassium ion transport, protein kinase B signaling cascade, protein phosphorylation, protein secretion, receptor internalization, response to external stimulus, sequestering of calcium ion, synaptic transmission, synaptic transmission, glutamatergic, transcription from RNA polymerase II promoter ENSG00000149295, ENSG00000158748, ENSG00000178394, ENSG00000184845
Cerlapirdine 501 1 0.0012E0 HTR6 amine transport, synaptic transmission ENSG00000158748
Ibipinabant, Rimonabant 495 7 0.0011E0 CNR1 amine transport, apoptotic process, fever generation, neuron projection development, response to external stimulus ENSG00000118432
Bepridil 500 2 0.001E0 CACNA1D, CACNA1H, KCNA5, KCNQ1 acrosome reaction, calcium ion transport, gene expression, insulin secretion, potassium ion transmembrane transport, potassium ion transport ENSG00000053918, ENSG00000130037, ENSG00000157388, ENSG00000196557
Clofilium phosphate, Dalfampridine, Pilsicainide, Pilsicainide hydrochloride hydrate 500 2 0.001E0 KCNA5 potassium ion transport ENSG00000130037
Delanzomib, Marizomib 500 2 8.0E-4 PSMB1 G1/S transition of mitotic cell cycle, cell cycle arrest, protein ubiquitination ENSG00000008018
Calcium valproate, Divalproex sodium, Sodium valproate 501 1 6.0E-4 CACNA1H, HDAC5, HDAC6, HDAC7, HDAC8 acrosome reaction, apoptotic process, cell migration involved in sprouting angiogenesis, cellular protein metabolic process, epithelial cell migration, interleukin-2 production, microtubule depolymerization, myotube differentiation, osteoblast differentiation, proteolysis, receptor biosynthetic process, signal transduction, transcription from RNA polymerase II promoter, transcription, DNA-dependent ENSG00000061273, ENSG00000094631, ENSG00000108840, ENSG00000147099, ENSG00000196557
Abexinostat, Belinostat, Panobinostat, Romidepsin 501 1 6.0E-4 HDAC5, HDAC6, HDAC7, HDAC8 apoptotic process, cell migration involved in sprouting angiogenesis, cellular protein metabolic process, epithelial cell migration, interleukin-2 production, microtubule depolymerization, myotube differentiation, osteoblast differentiation, proteolysis, receptor biosynthetic process, signal transduction, transcription from RNA polymerase II promoter, transcription, DNA-dependent ENSG00000061273, ENSG00000094631, ENSG00000108840, ENSG00000147099
Miconazole 501 1 4.0E-4 KCNN4, NOS2 T cell receptor signaling pathway, gene expression, killing of cells of other organism, leukocyte mediated cytotoxicity, protein catabolic process, protein secretion, vasodilation ENSG00000007171, ENSG00000104783
Halothane 501 1 4.0E-4 GRIN2A, KCNN4 T cell receptor signaling pathway, apoptotic process, protein catabolic process, protein secretion ENSG00000104783, ENSG00000183454
Clotrimazole 501 1 4.0E-4 KCNN4 T cell receptor signaling pathway, protein secretion ENSG00000104783
Foretinib, Golvatinib, Tivantinib 501 1 4.0E-4 MET MAPK cascade, protein phosphorylation, transcription from RNA polymerase II promoter ENSG00000105976
Cabozantinib 501 1 4.0E-4 MET, RET MAPK cascade, metanephric glomerulus development, protein phosphorylation, transcription from RNA polymerase II promoter ENSG00000105976, ENSG00000165731
Pipotiazine 501 1 1.0E-4 DRD1, DRD2, HTR1A ERK1 and ERK2 cascade, G-protein coupled receptor signaling pathway, amine transport, cAMP biosynthetic process, cell development, cell migration, cell proliferation, cellular component organization, cellular process, circadian sleep/wake cycle, sleep, dopamine uptake involved in synaptic transmission, insulin secretion, multicellular organism growth, neuroblast proliferation, potassium ion transport, protein kinase B signaling cascade, protein phosphorylation, protein secretion, receptor internalization, response to external stimulus, sequestering of calcium ion, synaptic transmission, synaptic transmission, glutamatergic, transcription from RNA polymerase II promoter ENSG00000149295, ENSG00000178394, ENSG00000184845
Lurasidone hydrochloride 501 1 1.0E-4 DRD2, HTR1A, HTR2C ERK1 and ERK2 cascade, G-protein coupled receptor signaling pathway, amine transport, cAMP biosynthetic process, cell development, cell migration, cell proliferation, cellular component organization, cellular process, circadian sleep/wake cycle, sleep, dopamine uptake involved in synaptic transmission, insulin secretion, locomotion, multicellular organism growth, neuroblast proliferation, protein kinase B signaling cascade, protein phosphorylation, protein secretion, receptor internalization, response to external stimulus, sequestering of calcium ion, synaptic transmission, glutamatergic, transcription from RNA polymerase II promoter ENSG00000147246, ENSG00000149295, ENSG00000178394
Alverine, Lecozotan hydrochloride 501 1 1.0E-4 HTR1A cell proliferation, cellular process ENSG00000178394
Acepromazine, Thioproperazine 501 1 1.0E-4 ADRA1B, DRD1, DRD2, HTR1A ERK1 and ERK2 cascade, G-protein coupled receptor signaling pathway, MAPK cascade, amine transport, cAMP biosynthetic process, cell development, cell migration, cell proliferation, cellular catabolic process, cellular component organization, cellular process, circadian sleep/wake cycle, sleep, dopamine uptake involved in synaptic transmission, glycogen catabolic process, heart contraction, insulin secretion, multicellular organism growth, neuroblast proliferation, potassium ion transport, protein kinase B signaling cascade, protein phosphorylation, protein secretion, receptor internalization, response to external stimulus, sequestering of calcium ion, synaptic transmission, synaptic transmission, glutamatergic, transcription from RNA polymerase II promoter ENSG00000149295, ENSG00000170214, ENSG00000178394, ENSG00000184845
Trimipramine 501 1 1.0E-4 ADRA1B, HTR1A MAPK cascade, cell proliferation, cellular catabolic process, cellular process, glycogen catabolic process, heart contraction ENSG00000170214, ENSG00000178394
Alprenolol, Penbutolol sulfate, Pindolol 501 1 1.0E-4 ADRB1, HTR1A cAMP biosynthetic process, cell growth involved in cardiac muscle cell development, cell proliferation, cellular process, heart contraction, multicellular organism growth, multicellular organismal metabolic process, muscle organ development, saliva secretion, smooth muscle contraction ENSG00000043591, ENSG00000178394
Nefazodone 500 2 1.0E-4 ADRA2A, HTR1A, HTR2C adrenergic receptor signaling pathway, calcium ion-dependent exocytosis, cell proliferation, cellular process, lipid catabolic process, locomotion ENSG00000147246, ENSG00000150594, ENSG00000178394
Molindone, Spiperone 501 1 1.0E-4 DRD2, HTR1A ERK1 and ERK2 cascade, G-protein coupled receptor signaling pathway, amine transport, cAMP biosynthetic process, cell development, cell migration, cell proliferation, cellular component organization, cellular process, circadian sleep/wake cycle, sleep, dopamine uptake involved in synaptic transmission, insulin secretion, multicellular organism growth, neuroblast proliferation, protein kinase B signaling cascade, protein phosphorylation, protein secretion, receptor internalization, response to external stimulus, sequestering of calcium ion, synaptic transmission, glutamatergic, transcription from RNA polymerase II promoter ENSG00000149295, ENSG00000178394
Zuclopenthixol 501 1 0.0E0 ADRA2A, DRD1, DRD2 ERK1 and ERK2 cascade, G-protein coupled receptor signaling pathway, adrenergic receptor signaling pathway, amine transport, cAMP biosynthetic process, calcium ion-dependent exocytosis, cell development, cell migration, cell proliferation, cellular component organization, circadian sleep/wake cycle, sleep, dopamine uptake involved in synaptic transmission, insulin secretion, lipid catabolic process, multicellular organism growth, neuroblast proliferation, potassium ion transport, protein kinase B signaling cascade, protein phosphorylation, protein secretion, receptor internalization, response to external stimulus, sequestering of calcium ion, synaptic transmission, synaptic transmission, glutamatergic, transcription from RNA polymerase II promoter ENSG00000149295, ENSG00000150594, ENSG00000184845
Amoxapine 501 1 0.0E0 ADRA2A, CHRM1, DRD1, DRD2 ERK1 and ERK2 cascade, G-protein coupled receptor signaling pathway, adrenergic receptor signaling pathway, amine transport, cAMP biosynthetic process, calcium ion-dependent exocytosis, cell development, cell migration, cell proliferation, cellular component organization, circadian sleep/wake cycle, sleep, dopamine uptake involved in synaptic transmission, insulin secretion, ion transport, lipid catabolic process, multicellular organism growth, neuroblast proliferation, potassium ion transport, protein kinase B signaling cascade, protein phosphorylation, protein secretion, receptor internalization, response to external stimulus, sequestering of calcium ion, synaptic transmission, synaptic transmission, glutamatergic, transcription from RNA polymerase II promoter ENSG00000149295, ENSG00000150594, ENSG00000168539, ENSG00000184845
Trazodone 501 1 0.0E0 ADRA2A, HTR1A, HTR2C adrenergic receptor signaling pathway, calcium ion-dependent exocytosis, cell proliferation, cellular process, lipid catabolic process, locomotion ENSG00000147246, ENSG00000150594, ENSG00000178394
Propericiazine 501 1 0.0E0 ADRA1B, ADRA2A, DRD1, DRD2 ERK1 and ERK2 cascade, G-protein coupled receptor signaling pathway, MAPK cascade, adrenergic receptor signaling pathway, amine transport, cAMP biosynthetic process, calcium ion-dependent exocytosis, cell development, cell migration, cell proliferation, cellular catabolic process, cellular component organization, circadian sleep/wake cycle, sleep, dopamine uptake involved in synaptic transmission, glycogen catabolic process, heart contraction, insulin secretion, lipid catabolic process, multicellular organism growth, neuroblast proliferation, potassium ion transport, protein kinase B signaling cascade, protein phosphorylation, protein secretion, receptor internalization, response to external stimulus, sequestering of calcium ion, synaptic transmission, synaptic transmission, glutamatergic, transcription from RNA polymerase II promoter ENSG00000149295, ENSG00000150594, ENSG00000170214, ENSG00000184845
Dihydroergotoxine mesilate 501 1 0.0E0 ADRA2A adrenergic receptor signaling pathway, calcium ion-dependent exocytosis, lipid catabolic process ENSG00000150594
Dihydroergotoxine 501 1 0.0E0 ADRA2A, DRD1, GLUL adrenergic receptor signaling pathway, cAMP biosynthetic process, calcium ion-dependent exocytosis, cell migration, epithelial cell proliferation, insulin secretion, lipid catabolic process, potassium ion transport, response to external stimulus, synaptic transmission, synaptic transmission, glutamatergic ENSG00000135821, ENSG00000150594, ENSG00000184845